Abstract:

ABSTRACT】Objective To investigate the role of Akt/ mTOR signal pathway in the pathogenesis of basal cell carcinoma by observing the expressions of Akt and mTOR in basal cell carcinoma，and their clinical significances. Methods Immunohistochemical method was applied to detect the expressions of　Akt and mTOR in skin specimens including 37 cases of basal cell carcinoma and 16 cases of normal skin. Results The rate of positive expression of Akt in basal cell carcinoma and normal skin tissue were 62.2%,12.5% respectively. The rate of positive expression of mTOR in basal cell carcinoma and normal skin tissue were 83.8%, 37.5% respectively. There were significant differences between normal skin tissues and basal cell carcinoma in the expression of Akt and mTOR (P<0.05). There were significantly positive correlation between the expression of Akt and mTOR in basal cell carcinoma. Conclusion Akt/mTOR signal pathway may play an important role in the pathogenesis of basal cell carcinoma.

Key words: basal cell carcinoma, mTOR, Akt, immunohistochemistry