Chinese Journal of Dermatology ›› 2023, e20210893.doi: 10.35541/cjd.20210893

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Relationship between circular RNAs and skin tumors

Zheng Nana1, Zeng Rong2,3, Tao Yingkai4, Li Min1,3   

  1. 1Department of Mycology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; 2Department of Laser, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; 3Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China; 4Department of Dermatology, The First People′s Hospital of Changzhou, Changzhou 213000, Jiangsu, China
  • Received:2021-12-10 Revised:2022-04-26 Online:2023-01-05 Published:2023-03-20
  • Supported by:
    Changzhou Application Foundation Project(CJ20210145)

Abstract: 【Abstract】 Circular RNAs (circRNAs) are a type of endogenous noncoding RNAs with covalently looped structures. Compared with other noncoding RNAs, circRNAs have the characteristics of stable structures, high abundance and tissue-specific expression. Recent studies have demonstrated that circRNAs can act as sponges, decoys and scaffolds for microRNAs and proteins, and play an important role in skin tumors. This review summarizes recent advances in the functions and mechanisms of action of circRNAs in common skin tumors, in order to understand the way in which they affect skin tumors, and to assess the value of further research on them.

Key words: Skin neoplasms, Nevi and melanoma, Neoplasms, squamous cell, Neoplasms, basal cell, Hemangiosarcoma, circRNA