Chinese Journal of Dermatology ›› 2024, e20220793.doi: 10.35541/cjd.20220793

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Associations between smoking and atopic dermatitis

Ma Tongchuan, Deng Tingyue, Xiao Fengli   

  1. Department of Dermatology and Venereology, the First Affiliated Hospital of Anhui Medical University, Institute of Dermatology, Anhui Medical University, Hefei 230022, China
  • Received:2022-11-09 Revised:2024-01-16 Online:2024-01-29 Published:2024-05-17
  • Contact: Xiao Fengli E-mail:xiaofengli@126.com
  • Supported by:
    National Natural Science Foundation of China (82373481);Key Project of Natural Science Research in Colleges and Universities in Anhui Province (2023AH053302)

Abstract: 【Abstract】 Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with genetic, immunological, and environmental factors. Smoking may induce and aggravate AD through various mechanisms such as impairing the skin barrier, epigenetic modifications, reducing regulatory T-cell function, activating the aryl hydrocarbon receptor, and oxidative stress. Smoking is closely related to the prevalence, severity, comorbidities and long-term control of AD. Conversely, patients with AD may have a higher rate of smoking. This review summarizes research progress on the relationship between smoking and AD.

Key words: Dermatitis, atopic, Smoking, Skin barrier, Epigenesis, genetic, T-lymphocytes, regulatory, Aryl hydrocarbon receptor, Oxidative stress