中性粒细胞在炎症性皮肤病中的研究进展

doi:10.35541/cjd.20220865

Abstract

Abstract: 【Abstract】 Neutrophils are important in the immune defense system. Historically, neutrophils have been regarded as participants in innate immunity. Now, with the deepening of research, it has been found that neutrophils have regulatory properties, which can guide and regulate the local immune response by transmitting activation, inhibition and migration signals. In recent years, several studies related to inflammatory dermatoses have revealed the important roles of neutrophils in the occurrence and development of skin diseases. In psoriasis, neutrophils can indirectly enhance inflammatory response through interleukin-17/interleukin-23 axis or antimicrobial peptides; in systemic lupus erythematosus, neutrophils can regulate the interferon signal transduction and the formation of autoantibodies; in atopic dermatitis, neutrophils can affect bacterial colonization and itching, etc. In a word, the main mechanisms of action of neutrophils in inflammatory dermatoses include the involvement of neutrophils in immune cell communication networks to regulate disease development and the multiple roles of NETosis as a mode of neutrophil inflammatory death in disease immunity. This review summarizes the research progress on the roles of neutrophils in the occurrence and development of some inflammatory dermatoses.

Key words: Neutrophils, Psoriasis, Lupus erythematosus, systemic, Dermatitis, atopic, Dermatitis, contact, Neutrophilic dermatoses

Chen Xingyu, Yao Xu. Role of neutrophils in inflammatory dermatoses[J]. Chinese Journal of Dermatology,2024,e20220865. doi:10.35541/cjd.20220865

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Role of neutrophils in inflammatory dermatoses

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