Chinese Journal of Dermatology ›› 2022, Vol. 55 ›› Issue (4): 357-361.doi: 10.35541/cjd.20201117

• Reviews • Previous Articles     Next Articles

Mechanisms of pruritus in atopic dermatitis

Wang Ao, Yao Xu   

  1. Department of Allergy and Rheumatology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2020-11-20 Revised:2020-12-30 Online:2022-04-15 Published:2022-04-01
  • Contact: Yao Xu E-mail:dryao_xu@126.com
  • Supported by:
    National Natural Science Foundation of China (82073446); The Key Project of Social Development in Jiangsu Province (BE2020632); The Nanjing Incubation Program for National Clinical Research Center (2019060001); CAMS Innovation Fund for Medical Sciences (2016-I2M-1-005)

Abstract: 【Abstract】 Pruritus in atopic dermatitis (AD) is a typical non-histaminergic itch involving complex nerve pathways. A variety of cytokines and neuropeptides, skin barrier dysfunction and skin microbiome imbalance are also involved in the generation and transmission of itching-relatd signals. This review focuses on main research progress in the pathogenesis and treatment of pruritus in AD in recent years.

Key words: Dermatitis, atopic, Pruritus, Cytokines, Skin barrier, Skin microbiome