普瑞巴林在皮肤科的应用进展

doi:10.35541/cjd.20180715

Abstract

Abstract: 【Abstract】 Pregabalin can reduce the release of multiple neurotransmitters by acting on the voltage?gated calcium channel of the nervous system. It is currently widely used in a variety of diseases, including neuropathic pain, generalized anxiety disorder, epilepsy and so on. In dermatology department, pregabalin also has a therapeutic effect on postherpetic neuralgia, prurigo nodularis, uremic pruritus, nerve?related pruritus and mentally relevant pruritus.

Key words: GABA antagonists, Therapy, Pruritus, Neuralgia, postherpetic, Skin diseases, Pregabalin

Xiang Ruiyu, Li Suo, Feng Suying. Application of pregabalin in dermatology[J]. Chinese Journal of Dermatology, 2020, 53(3): 233-235.doi:10.35541/cjd.20180715

References ［32］

［1］	Matsuda KM, Sharma D, Schonfeld AR, et al. Gabapentin and pregabalin for the treatment of chronic pruritus［J］. J Am Acad Dermatol, 2016,75（3）:619⁃625.e6. doi: 10.1016/j.jaad.2016.02. 1237.
［2］	Lam DM, Choi SW, Wong SS, et al. Efficacy of pregabalin in acute postoperative pain under different surgical categories: a Meta⁃analysis［J］. Medicine （Baltimore）, 2015,94（46）:e1944. doi: 10.1097/MD.0000000000001944.
［3］	Calandre EP, Rico⁃Villademoros F, Slim M. Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use［J］. Expert Rev Neurother, 2016,16（11）:1263⁃1277. doi: 10.1080/14737175. 2016.1202764.
［4］	Kukkar A, Bali A, Singh N, et al. Implications and mechanism of action of gabapentin in neuropathic pain［J］. Arch Pharm Res, 2013,36（3）:237⁃251. doi: 10.1007/s12272⁃013⁃0057⁃y.
［5］	Johnson RW, Rice AS. Clinical practice. Postherpetic neuralgia ［J］. N Engl J Med, 2014, 371（16）:1526⁃1533. doi: 10.1056/NEJMcp1403062.
［6］	Vargas⁃Espinosa ML, Sanmartí⁃García G, Vázquez⁃Delgado E, et al. Antiepileptic drugs for the treatment of neuropathic pain: a systematic review［J］. Med Oral Patol Oral Cir Bucal, 2012,17（5）:e786⁃e793.
［7］	Foroutan N, Nikvarz N. Role of pregabalin in management of pruritus: a literature review［J］. J Pharm Pharm Sci, 2016,19（4）:465⁃474. doi: 10.18433/J35K6N.
［8］	Asplund M, Calling S, Spirén A, et al. Prurigo nodularis⁃⁃pregabalin can be considered for more severe symptoms［J］. Lakartidningen, 2015,112. pii: DRFM.
［9］	Boyd ST, Mihm L, Causey NW. Improvement in psoriasis following treatment with gabapentin and pregabalin［J］. Am J Clin Dermatol, 2008,9（6）:419. doi: 10.2165/0128071⁃200809060⁃ 00012.
［10］	Remröd C, Sjöström K, Svensson Å. Pruritus in psoriasis: a study of personality traits, depression and anxiety［J］. Acta Derm Venereol, 2015,95（4）:439⁃443. doi: 10.2340/00015555⁃1975.
［11］	Szepietowski JC, Reich A. Pruritus in psoriasis: an update［J］. Eur J Pain, 2016,20（1）:41⁃46. doi: 10.1002/ejp.768.
［12］	Kuypers DR. Skin problems in chronic kidney disease［J］. Nat Clin Pract Nephrol, 2009,5（3）:157⁃170. doi: 10.1038/ncpneph 1040.
［13］	Mettang T, Kremer AE. Uremic pruritus［J］. Kidney Int, 2015,87（4）:685⁃691. doi: 10.1038/ki.2013.454.
［14］	Simonsen E, Komenda P, Lerner B, et al. Treatment of uremic pruritus: a systematic review［J］. Am J Kidney Dis, 2017,70（5）:638⁃655. doi: 10.1053/j.ajkd.2017.05.018.
［15］	Foroutan N, Etminan A, Nikvarz N, et al. Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial［J］. Hemodial Int, 2017,21（1）:63⁃71. doi: 10.1111/hdi.12455.
［16］	Gupta MA, Pur DR, Vujcic B, et al. Use of antiepileptic mood stabilizers in dermatology［J］. Clin Dermatol, 2018,36（6）:756⁃764. doi: 10.1016/j.clindermatol.2018.08.005.
［17］	Ahuja RB, Gupta GK. A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post⁃burn pruritus［J］. Burns, 2013,39（1）:24⁃29. doi: 10.1016/j.burns.2012.09.016.
［18］	Yilmaz S, Ceyhan AM, Baysal Akkaya V. Brachioradial pruritus succesfully treated with gabapentin［J］. 2010,37（7）:662⁃665. doi: 10.1111/j.1346⁃8138.2010.00830.x.
［19］	Atış G, Bilir KB. Pregabalin treatment of three cases with brachioradial pruritus［J］. Dermatol Ther, 2017,30:e12459. doi: 10.1111/dth.12459.
［20］	Iqbal Z, Azmi S, Yadav R, et al. Diabetic peripheral neuropathy: epidemiology, diagnosis, and pharmacotherapy［J］. Clin Ther, 2018,40（6）:828⁃849. doi: 10.1016/j.clinthera.2018.04.001.
［21］	Şavk E. Neurologic itch management［J］. Curr Probl Dermatol, 2016,50:116⁃123. doi: 10.1159/000446053.
［22］	Picardi A, Abeni D, Melchi CF, et al. Psychiatric morbidity in dermatological outpatients: an issue to be recognized［J］. Br J Dermatol, 2000,143（5）:983⁃991.
［23］	Tey HL, Wallengren J, Yosipovitch G. Psychosomatic factors in pruritus［J］.Clin Dermatol, 2013,31（1）:31⁃40. doi: 10.1016/j.clindermatol.2011.11.004.
［24］	Melvin CL, Carey TS, Goodman F, et al. Effectiveness of antiepileptic drugs for the treatment of bipolar disorder: findings from a systematic review［J］. J Psychiatr Pract, 2008,14 Suppl 1:9⁃14. doi: 10.1097/01.pra.0000333583.75741.8b.
［25］	Ettinger AB, Argoff CE. Use of antiepileptic drugs for nonepileptic conditions: psychiatric disorders and chronic pain［J］. Neurotherapeutics, 2007,4（1）:75⁃83. doi: 10.1016/j.nurt. 2006.10.003.
［26］	Misery L, Alexandre S, Dutray S, et al. Functional itch disorder or psychogenic pruritus: suggested diagnosis criteria from the French psychodermatology group［J］. Acta Derm Venereol, 2007,87（4）:341⁃344. doi: 10.2340/00015555⁃0266.
［27］	Altunay IK, Atis G, Esen K, et al. Impact of functional pruritus compared with mild psoriasis on quality of life: a cross⁃sectional questionnaire study in Turkey［J］. Am J Clin Dermatol, 2014,15（4）:365⁃370. doi: 10.1007/s40257⁃014⁃0075⁃7.
［28］	Park JM, Jwa SW, Song M, et al. Efficacy and safety of pregabalin for the treatment of chronic pruritus in Korea［J］. J Dermatol, 2012,39（9）:790⁃791. doi: 10.1111/j.1346⁃8138.2012. 01572.x.
［29］	Laniosz V, Wetter DA, Godar DA. Dermatologic manifestations of fibromyalgia［J］. Clin Rheumatol, 2014,33（7）:1009⁃1013. doi: 10.1007/s10067⁃014⁃2488⁃3.
［30］	Häuser W, Bernardy K, Uçeyler N, et al. Treatment of fibromyalgia syndrome with gabapentin and pregabalin⁃⁃a meta⁃analysis of randomized controlled trials［J］. Pain, 2009,145（1⁃2）:69⁃81. doi: 10.1016/j.pain.2009.05.014.
［31］	Liu Q, Chen H, Xi L, et al. A randomized, double⁃blind, placebo⁃controlled trial to evaluate the efficacy and safety of pregabalin for postherpetic neuralgia in a population of Chinese patients［J］. Pain Pract, 2017,17（1）:62⁃69. doi: 10.1111/papr. 12413.
［32］	Baldwin DS, den Boer JA, Lyndon G, et al. Efficacy and safety of pregabalin in generalised anxiety disorder: a critical review of the literature［J］. J Psychopharmacol, 2015,29（10）:1047⁃1060. doi: 10.1177/0269881115598411.

[1]	Zhu He, Wu Yingying, Yang Rongya, Wang Congmin, Ao Junhong. Efficacy of medical cold patches in relieving burning pain and restoring skin homeostasis after hematoporphyrin monomethyl ether-based photodynamic therapy for the treatment of port-wine stains [J]. Chinese Journal of Dermatology, 2022, 55(9): 784-789.
[2]	Zheng Jiayuan, Yu Bingqian, Chen Xianxia, Luo Zhicheng. Characteristics of pruritus in adult patients with psoriasis vulgaris and its effect on quality of life [J]. Chinese Journal of Dermatology, 2022, 55(9): 790-794.
[3]	Wei Jin, Zang Dongjie, Zeng Sanwu, Jiang Jing, Lun Wenhui. Mutation analysis of the KRT5 gene in a Chinese pedigree with Dowling-Degos disease [J]. Chinese Journal of Dermatology, 2022, 55(8): 703-705.
[4]	Fan Birao, Chen Xixue, Wang Mingyue. Retrospective analysis of efficacy and safety of minocycline alone or in combination with low-dose glucocorticoids in the treatment of 15 cases of pemphigus erythematosus and 9 cases of pemphigus herpetiformis [J]. Chinese Journal of Dermatology, 2022, 55(8): 676-681.
[5]	Cao Miao, Chong Shan, Hu Xinyuan, Zhu Xuejun, Wang Mingyue. Analysis of skin and mucosal infections and their management after primary tumor resection in patients with paraneoplastic pemphigus [J]. Chinese Journal of Dermatology, 2022, 55(8): 669-675.
[6]	Jin Liang, Liu Ling. Treatment of some genodermatoses [J]. Chinese Journal of Dermatology, 2022, 55(8): 735-739.
[7]	Xu Zhe. Some thoughts on hereditary dermatoses [J]. Chinese Journal of Dermatology, 2022, 55(8): 651-652.
[8]	Bao Yingqiu, Zhang Yanjun, Li Bo, Gong Jing, Fu Yu, Xu Zhe. Gene therapy for recessive dystrophic epidermolysis bullosa [J]. Chinese Journal of Dermatology, 2022, 55(8): 739-743.
[9]	Zhang Ning, Li Shu, Li Jing . Efficacy of immune checkpoint inhibitors and targeted therapy in adjuvant treatment of resectable melanoma: a network meta-analysis [J]. Chinese Journal of Dermatology, 2022, 55(7): 603-609.
[10]	Wang Yuan, Li Zhiliang, Li Suo, Jing Ke, Sun Chao, Liang Guirong, Zhang Hanmei, Feng Suying. Clinical and immunoserological features of 7 cases of anti-p200 pemphigoid [J]. Chinese Journal of Dermatology, 2022, 55(7): 557-561.
[11]	Working Group for Atopic Dermatitis, Chinese Society of Dermatology, Working Group for Children′s Diseases, Chinese Society of Dermatology. Treatment of atopic dermatitis with dupilumab: an expert consensus [J]. Chinese Journal of Dermatology, 2022, 55(6): 465-470.
[12]	Committee on Autoimmune Diseases, China Dermatologist Association. Cyclosporine in the treatment of immune-related skin diseases: an expert proposal [J]. Chinese Journal of Dermatology, 2022, 55(6): 471-479.
[13]	Zhao Liuqi, Chen Yan, Chen Danyang, Fan Birao, Wang Rui, Shang Panpan, Chen Xixue, Zhu Xuejun, Wang Mingyue. Efficacy and safety of dupilumab in the treatment of 21 cases of bullous pemphigoid: a retrospective study [J]. Chinese Journal of Dermatology, 2022, 55(6): 480-485.
[14]	Wen Guangdong, Mao Dandan, Zhang Yuanyuan, Dou Yuanqing, Zhao Pei, Wu Chenyu, Zhang Jianzhong. A case of generalized lichen amyloidosis treated with dupilumab: the first case reported in China [J]. Chinese Journal of Dermatology, 2022, 55(6): 508-510.
[15]	Shan Ying, Zuo Yagang. Correlation between autoimmune bullous diseases and psoriasis [J]. Chinese Journal of Dermatology, 2022, 55(5): 452-455.

Application of pregabalin in dermatology

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［32］

Related Articles 15

Metrics

Comments

Recommended 10