吸烟与特应性皮炎相关性研究进展

doi:10.35541/cjd.20220793

Abstract

Abstract: 【Abstract】 Atopic dermatitis （AD） is a chronic inflammatory skin disease associated with genetic, immunological, and environmental factors. Smoking may induce and aggravate AD through various mechanisms such as impairing the skin barrier, epigenetic modifications, reducing regulatory T-cell function, activating the aryl hydrocarbon receptor, and oxidative stress. Smoking is closely related to the prevalence, severity, comorbidities and long-term control of AD. Conversely, patients with AD may have a higher rate of smoking. This review summarizes research progress on the relationship between smoking and AD.

Key words: Dermatitis, atopic, Smoking, Skin barrier, Epigenesis, genetic, T-lymphocytes, regulatory, Aryl hydrocarbon receptor, Oxidative stress

Ma Tongchuan, Deng Tingyue, Xiao Fengli. Associations between smoking and atopic dermatitis[J]. Chinese Journal of Dermatology,2024,e20220793. doi:10.35541/cjd.20220793

References ［29］

［1］	Langan SM, Irvine AD, Weidinger S. Atopic dermatitis［J］. Lancet, 2020,396（10247）:345⁃360. doi: 10.1016/S0140⁃6736（20）31286⁃1.
［2］	Suaini N, Tan C, Loo E, et al. Global differences in atopic dermatitis［J］. Pediatr Allergy Immunol, 2021,32（1）:23⁃33. doi: 10.1111/pai.13335.
［3］	Dong WL, An J, Yu M, et al. The prevalence and year lived with disability of atopic dermatitis in China: Findings from the global burden of disease study 2019［J］. World Allergy Organ J, 2021,14（11）:100604. doi: 10.1016/j.waojou.2021.100604.
［4］	Stefanovic N, Flohr C, Irvine AD. The exposome in atopic dermatitis［J］. Allergy, 2020,75（1）:63⁃74. doi: 10.1111/all. 13946.
［5］	Celebi Sözener Z, Cevhertas L, Nadeau K, et al. Environmental factors in epithelial barrier dysfunction［J］. J Allergy Clin Immunol, 2020,145（6）:1517⁃1528. doi: 10.1016/j.jaci.2020. 04.024.
［6］	Nagata H, Takagi N, Inoue S, et al. Nicotine affects tight junction barriers via alpha7 nicotine⁃like acetylcholine receptor in keratinocytes［J］. J Dermatol Sci, 2021,103（3）:183⁃185. doi: 10.1016/j.jdermsci.2021.07.001.
［7］	Nedoszytko B, Reszka E, Gutowska⁃Owsiak D, et al. Genetic and epigenetic aspects of atopic dermatitis［J］. Int J Mol Sci, 2020,21（18）:6484. doi: 10.3390/ijms21186484.
［8］	Wang IJ, Chen SL, Lu TP, et al. Prenatal smoke exposure, DNA methylation, and childhood atopic dermatitis［J］. Clin Exp Allergy, 2013,43（5）:535⁃543. doi: 10.1111/cea.12108.
［9］	Herberth G, Bauer M, Gasch M, et al. Maternal and cord blood miR⁃223 expression associates with prenatal tobacco smoke exposure and low regulatory T⁃cell numbers［J］. J Allergy Clin Immunol, 2014,133（2）:543⁃550. doi: 10.1016/j.jaci.2013. 06.036.
［10］	Palomares O, Yaman G, Azkur AK, et al. Role of Treg in immune regulation of allergic diseases［J］. Eur J Immunol, 2010,40（5）:1232⁃1240. doi: 10.1002/eji.200940045.
［11］	Winter M, Thürmann L, Gu Z, et al. The benzene metabolite 1,4⁃benzoquinone reduces regulatory T⁃cell function: a potential mechanism for tobacco smoke⁃associated atopic dermatitis［J］. J Allergy Clin Immunol, 2017,140（2）:603⁃605. doi: 10.1016/j.jaci.2017.01.034.
［12］	Hong CH, Lee CH, Yu HS, et al. Benzopyrene, a major polyaromatic hydrocarbon in smoke fume, mobilizes Langerhans cells and polarizes Th2/17 responses in epicutaneous protein sensitization through the aryl hydrocarbon receptor［J］. Int Immunopharmacol, 2016,36:111⁃117. doi: 10.1016/j.intimp. 2016.04.017.
［13］	Pecorelli A, Woodby B, Prieux R, et al. Involvement of 4⁃hydroxy⁃2⁃nonenal in pollution⁃induced skin damage［J］. Biofactors, 2019,45（4）:536⁃547. doi: 10.1002/biof.1513.
［14］	Ng YT, Chew FT. A systematic review and meta⁃analysis of risk factors associated with atopic dermatitis in Asia［J］. World Allergy Organ J, 2020,13（11）:100477. doi: 10.1016/j.waojou. 2020.100477.
［15］	Lee A, Lee SY, Lee KS. The use of heated tobacco products is associated with asthma, allergic rhinitis, and atopic dermatitis in Korean adolescents［J］. Sci Rep, 2019,9（1）:17699. doi: 10. 1038/s41598⁃019⁃54102⁃4.
［16］	Kim SY, Sim S, Choi HG. Atopic dermatitis is associated with active and passive cigarette smoking in adolescents［J］. PLoS One, 2017,12（11）:e0187453. doi: 10.1371/journal.pone. 0187453.
［17］	Kantor R, Kim A, Thyssen JP, et al. Association of atopic dermatitis with smoking: a systematic review and meta⁃analysis［J］. J Am Acad Dermatol, 2016,75（6）:1119⁃1125.e1. doi: 10.1016/j.jaad.2016.07.017.
［18］	Özdoğru EE, Gönülal M. Atopic dermatitis, inhalant allergy and food allergy: a paediatric approach［J］. Dermatol Ther, 2021,34（1）:e14542. doi: 10.1111/dth.14542.
［19］	Lee A, Lee SY, Lee KS. Association of secondhand smoke exposure with allergic multimorbidity in Korean adolescents［J］. Sci Rep, 2020,10（1）:16409. doi: 10.1038/s41598⁃020⁃73430⁃4.
［20］	Taylor⁃Robinson DC, Williams H, Pearce A, et al. Do early⁃life exposures explain why more advantaged children get eczema? Findings from the U.K. Millennium Cohort Study［J］. Br J Dermatol, 2016,174（3）:569⁃578. doi: 10.1111/bjd.14310.
［21］	Salava A, Salo V, Leppänen J, et al. Factors associated with severity of atopic dermatitis ⁃ a Finnish cross⁃sectional study［J］. J Eur Acad Dermatol Venereol, 2022,36（11）:2130⁃2139. doi: 10.1111/jdv.18378.
［22］	Zhang J, Loman L, Oldhoff M, et al. Association between moderate to severe atopic dermatitis and lifestyle factors in the Dutch general population［J］. Clin Exp Dermatol, 2022,47（8）:1523⁃1535. doi: 10.1111/ced.15212.
［23］	Jing D, Li J, Tao J, et al. Associations of second⁃hand smoke exposure with hand eczema and atopic dermatitis among college students in China［J］. Sci Rep, 2020,10（1）:17400. doi: 10.1038/s41598⁃020⁃74501⁃2.
［24］	Morra DE, Cho E, Li T, et al. Smoking and risk of adult⁃onset atopic dermatitis in US women［J］. J Am Acad Dermatol, 2021,84（2）:561⁃563. doi: 10.1016/j.jaad.2020.07.077.
［25］	Andersen YM, Egeberg A, Gislason GH, et al. Autoimmune diseases in adults with atopic dermatitis［J］. J Am Acad Dermatol, 2017,76（2）:274⁃280.e1. doi: 10.1016/j.jaad.2016.08.047.
［26］	Thyssen JP, Skov L, Hamann CR, et al. Assessment of major comorbidities in adults with atopic dermatitis using the Charlson comorbidity index［J］. J Am Acad Dermatol, 2017,76（6）:1088⁃1092.e1. doi: 10.1016/j.jaad.2017.01.030.
［27］	Pilz AC, Schielein MC, Schuster B, et al. Atopic dermatitis: disease characteristics and comorbidities in smoking and non⁃smoking patients from the TREATgermany registry［J］. J Eur Acad Dermatol Venereol, 2022,36（3）:413⁃421. doi: 10.1111/jdv.17789.
［28］	Pilz AC, Durner V, Schielein MC, et al. Addictions in patients with atopic dermatitis: a cross⁃sectional pilot study in Germany［J］. J Eur Acad Dermatol Venereol, 2022,36（1）:84⁃90. doi: 10.1111/jdv.17708.
［29］	Manjunath J, Silverberg NB, Silverberg JI. Association of atopic dermatitis with delinquent behaviors in US children and adolescents［J］. Arch Dermatol Res, 2022,314（10）:975⁃982. doi: 10.1007/s00403⁃021⁃02314⁃y.

[1]	Zhang Yude, Wang Hongjuan, Kang Xiaojing. Stem cell therapy for vitiligo: advances in basic and clinical research [J]. Chinese Journal of Dermatology, 2025, 58(9): 878-881.
[2]	Xu Xuqing, Hu Wen, Kang Xiaojing. Cell ferroptosis in the pathogenesis of vitiligo and advances in related therapeutic agents [J]. Chinese Journal of Dermatology, 2025, 58(9): 886-889.
[3]	Zhang Chengfeng, Jin Shanglin. New insights into the pathogenesis and clinical therapeutic strategies of melasma [J]. Chinese Journal of Dermatology, 2025, 58(9): 797-800.
[4]	Zhou Miaoni, Sheng Anqi, Fu Lifang, Jin Rong, Xu Wen, Wei Xiaodong, Xu Ai′e . Efficacy and safety of an antioxidant gel containing tea polyphenols combined with narrow-band ultraviolet B in the treatment of vitiligo: a single-center randomized controlled trial [J]. Chinese Journal of Dermatology, 2025, 58(9): 834-838.
[5]	Li Qianwen, Liao Zhikai, Le Yue, Duan Bolin, Geng Mengmeng, Lei Tiechi. The antioxidant Tempol inhibits pigment loss in tail skin of a mouse model of immune-induced vitiligo under oxidative stress [J]. Chinese Journal of Dermatology, 2025, 58(2): 126-131.
[6]	Wang Qisa, Zhao Wenling, Han Xiufeng, Ma Huanyue, Shi Haitao, Ma Lin, Xu Zhe. Efficacy of a baby smoothing and special caring cream in reducing the recurrence of atopic dermatitis in infancy: a randomized controlled trial [J]. Chinese Journal of Dermatology, 2025, 58(10): 975-979.
[7]	Ai Fangting, Sun Zijun, Miao Guoying, Yao Chunxia. Role of calcium-sensing receptors in the pathophysiology of skin of the elderly [J]. Chinese Journal of Dermatology, 2025, 58(1): 76-79.
[8]	Chen Jiaxi, Yi Xiuli, Li Chunying, Li Shuli. Study on the protective effect of folic acid against oxidative stress-induced damage to melanocytes in vitro [J]. Chinese Journal of Dermatology, 2024, 57(6): 547-552.
[9]	Liu Yingying, Deng Danqi. Correlations between skin microbiome and skin tumors [J]. Chinese Journal of Dermatology, 2024, 0(3): 20230241-e20230241.
[10]	Sun Jiayi, Song Xiuzu. Role of transient receptor potential vanilloid type 4 channel in skin diseases [J]. Chinese Journal of Dermatology, 2024, 57(12): 1149-1152.
[11]	Dai Leheng, Hu Wen, Zhang Kunjie, Kang Xiaojing. Protective effects of isorhamnetin against H2O2-induced mitochondrial structural and functional damage in HaCaT cells [J]. Chinese Journal of Dermatology, 2023, 56(9): 857-861.
[12]	China Dermatologist Association. Guidance on application of moisturizers and emollients: an expert consensus （2023） [J]. Chinese Journal of Dermatology, 2023, 56(8): 711-717.
[13]	Song Kuangnan, Zhang Siping. Role of epigenetics in the pathogenesis of atopic dermatitis [J]. Chinese Journal of Dermatology, 2023, 56(12): 1167-1169.
[14]	Song Xiaoting, Liu Bo, Chen Yudi, Zhao Zuotao. Pathophysiological pathogenesis of rosacea [J]. Chinese Journal of Dermatology, 2022, 55(5): 446-449.
[15]	Wang Ao, Yao Xu. Mechanisms of pruritus in atopic dermatitis [J]. Chinese Journal of Dermatology, 2022, 55(4): 357-361.

Associations between smoking and atopic dermatitis

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［29］

Related Articles 15

Metrics

Comments

Recommended 10