瞬时受体电位通道香草酸亚型4离子通道在皮肤病中的作用研究

doi:10.35541/cjd.20210701

Abstract

Abstract: 【Abstract】 Transient receptor potential vanilloid type 4 （TRPV4）, the fourth member of the thermosensitive TRPV family, is a nonselective cation channel that is widely expressed in various tissues and cells. TRPV4 is involved in the physiological activities of various organs in the body by responding to both exogenous and endogenous stimuli. Studies have shown that TRPV4 participates in skin physiological and pathophysiological processes, including skin barrier repair and conduction of itch sensation, and also plays important roles in skin disorders, such as rosacea, alopecia, psoriasis, scleroderma, and skin cancer. This review summarizes research progress in the role of TRPV4 channels in skin diseases.

Key words: Transient receptor potential channels, Skin diseases, Skin barrier, Itch, Transient receptor potential vanilloid type 4

CLC Number:

Sun Jiayi, Song Xiuzu. Role of transient receptor potential vanilloid type 4 channel in skin diseases[J]. Chinese Journal of Dermatology, 2024, 57(12): 1149-1152.doi:10.35541/cjd.20210701

References ［36］

［1］	Nishimoto R, Derouiche S, Eto K, et al. Thermosensitive TRPV4 channels mediate temperature⁃dependent microglia movement［J］. Proc Natl Acad Sci U S A, 2021,118（17）:e2012894118.doi: 10.1073/pnas.2012894118.
［2］	Kwon DH, Zhang F, Suo Y, et al. Heat⁃dependent opening of TRPV1 in the presence of capsaicin［J］. Nat Struct Mol Biol, 2021,28（7）:554⁃563. doi: 10.1038/s41594⁃021⁃00616⁃3.
［3］	Nadezhdin KD, Neuberger A, Trofimov YA, et al. Structural mechanism of heat⁃induced opening of a temperature⁃sensitive TRP channel［J］. Nat Struct Mol Biol, 2021,28（7）:564⁃572. doi: 10.1038/s41594⁃021⁃00615⁃4.
［4］	Huang T, Xu T, Wang Y, et al. Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4［J］. Autophagy, 2021,17（11）:3592⁃3606. doi: 10.1080/15548627.2021.1885203.
［5］	Zhu Y, Wen L, Wang S, et al. Omega⁃3 fatty acids improve flow⁃induced vasodilation by enhancing TRPV4 in arteries from diet⁃induced obese mice［J］. Cardiovasc Res, 2021,117（12）:2450⁃2458. doi: 10.1093/cvr/cvaa296.
［6］	Gualdani R, Seghers F, Yerna X, et al. Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells［J］. Sci Signal, 2020,13（653）:eabc6967. doi: 10.1126/scisignal.abc6967.
［7］	Bonvini SJ, Birrell MA, Dubuis E, et al. Novel airway smooth muscle⁃mast cell interactions and a role for the TRPV4⁃ATP axis in non⁃atopic asthma［J］. Eur Respir J, 2020,56（1）:1901458. doi: 10.1183/13993003.01458⁃2019.
［8］	Kida N, Sokabe T, Kashio M, et al. Importance of transient receptor potential vanilloid 4 （TRPV4） in epidermal barrier function in human skin keratinocytes［J］. Pflugers Arch, 2012,463（5）:715⁃725. doi: 10.1007/s00424⁃012⁃1081⁃3.
［9］	Akazawa Y, Yuki T, Yoshida H, et al. Activation of TRPV4 strengthens the tight⁃junction barrier in human epidermal keratinocytes［J］. Skin Pharmacol Physiol, 2013,26（1）:15⁃21. doi: 10.1159/000343173.
［10］	Sokabe T, Fukumi⁃Tominaga T, Yonemura S, et al. The TRPV4 channel contributes to intercellular junction formation in keratinocytes［J］. J Biol Chem, 2010,285（24）:18749⁃18758. doi: 10.1074/jbc.M110.103606.
［11］	Kitsuki T, Yoshimoto RU, Aijima R, et al. Enhanced junctional epithelial permeability in TRPV4⁃deficient mice［J］. J Periodontal Res, 2020,55（1）:51⁃60. doi: 10.1111/jre.12685.
［12］	Denda M, Sokabe T, Fukumi⁃Tominaga T, et al. Effects of skin surface temperature on epidermal permeability barrier homeostasis［J］. J Invest Dermatol, 2007,127（3）:654⁃659. doi: 10.1038/sj.jid.5700590.
［13］	Sanjel B, Kim BH, Song MH, et al. Glucosylsphingosine evokes pruritus via activation of 5⁃HT2A receptor and TRPV4 in sensory neurons［J］. Br J Pharmacol, 2022,179（10）:2193⁃2207. doi: 10.1111/bph.15733.
［14］	Wai V, Roberts L, Michaud J, et al. The anatomical distribution of mechanoreceptors in mouse hind paw skin and the influence of integrin α1β1 on Meissner⁃like corpuscle density in the footpads［J］. Front Neuroanat, 2021,15:628711. doi: 10.3389/fnana.2021.628711.
［15］	Fujii N, Kenny GP, McGarr GW, et al. TRPV4 channel blockade does not modulate skin vasodilation and sweating during hyperthermia or cutaneous postocclusive reactive and thermal hyperemia［J］. Am J Physiol Regul Integr Comp Physiol, 2021,320（4）:R563⁃R573. doi: 10.1152/ajpregu.00123.2020.
［16］	Yang YS, Cho SI, Choi MG, et al. Increased expression of three types of transient receptor potential channels （TRPA1, TRPV4 and TRPV3） in burn scars with post⁃burn pruritus［J］. Acta Derm Venereol, 2015,95（1）:20⁃24. doi: 10.2340/00015555⁃1858.
［17］	Chen Y, Fang Q, Wang Z, et al. Transient receptor potential vanilloid 4 ion channel functions as a pruriceptor in epidermal keratinocytes to evoke histaminergic itch［J］. J Biol Chem, 2016,291（19）:10252⁃10262. doi: 10.1074/jbc.M116.716464.
［18］	Kittaka H, Yamanoi Y, Tominaga M. Transient receptor potential vanilloid 4 （TRPV4） channel as a target of crotamiton and its bimodal effects［J］. Pflugers Arch, 2017,469（10）:1313⁃1323. doi: 10.1007/s00424⁃017⁃1998⁃7.
［19］	Luo J, Feng J, Yu G, et al. Transient receptor potential vanilloid 4⁃expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch［J］. J Allergy Clin Immunol, 2018,141（2）:608⁃619.e7. doi: 10.1016/j.jaci.2017.05.051.
［20］	Lee WJ, Shim WS. Cutaneous neuroimmune interactions of TSLP and TRPV4 play pivotal roles in dry skin⁃induced pruritus［J］. Front Immunol, 2021,12:772941. doi: 10.3389/fimmu.2021.77 2941.
［21］	Chen Y, Wang ZL, Yeo M, et al. Epithelia⁃sensory neuron cross talk underlies cholestatic itch induced by lysophosphatidyl⁃choline［J］. Gastroenterology, 2021,161（1）:301⁃317.e16. doi: 10. 1053/j.gastro.2021.03.049.
［22］	Sulk M, Seeliger S, Aubert J, et al. Distribution and expression of non⁃neuronal transient receptor potential （TRPV） ion channels in rosacea［J］. J Invest Dermatol, 2012,132（4）:1253⁃1262. doi: 10.1038/jid.2011.424.
［23］	Mascarenhas NL, Wang Z, Chang YL, et al. TRPV4 mediates mast cell activation in cathelicidin⁃induced rosacea inflammation［J］. J Invest Dermatol, 2017,137（4）:972⁃975. doi: 10.1016/j.jid.2016.10.046.
［24］	Szabó IL, Herczeg⁃Lisztes E, Szegedi A, et al. TRPV4 is expressed in human hair follicles and inhibits hair growth in vitro［J］. J Invest Dermatol, 2019,139（6）:1385⁃1388. doi: 10.1016/j.jid.2018.11.020.
［25］	Yang P, Lu P, Luo J, et al. Transient stimulation of TRPV4⁃expressing keratinocytes promotes hair follicle regeneration in mice［J］. Br J Pharmacol, 2020,177（18）:4181⁃4192. doi: 10. 1111/bph.15161.
［26］	Purzycka⁃Bohdan D, Kisielnicka A, Zabłotna M, et al. Chronic plaque psoriasis in Poland: disease severity, prevalence of comorbidities, and quality of life［J］. J Clin Med, 2022,11（5）:1254. doi: 10.3390/jcm11051254.
［27］	Huang KF, Ma KH, Liu PS, et al. Baicalein increases keratin 1 and 10 expression in HaCaT keratinocytes via TRPV4 receptor activation［J］. Exp Dermatol, 2016,25（8）:623⁃629. doi: 10.1111/exd.13024.
［28］	Sakai K, Sanders KM, Youssef MR, et al. Mouse model of imiquimod⁃induced psoriatic itch［J］. Pain, 2016,157（11）:2536⁃2543. doi: 10.1097/j.pain.0000000000000674.
［29］	Yan J, Ye F, Ju Y, et al. Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4［J］. Cell Calcium, 2021,97:102429. doi: 10.1016/j.ceca.2021.102429.
［30］	Goswami R, Cohen J, Sharma S, et al. TRPV4 ion channel is associated with scleroderma［J］. J Invest Dermatol, 2017,137（4）:962⁃965. doi: 10.1016/j.jid.2016.10.045.
［31］	Sharma S, Goswami R, Merth M, et al. TRPV4 ion channel is a novel regulator of dermal myofibroblast differentiation［J］. Am J Physiol Cell Physiol, 2017,312（5）:C562⁃C572. doi: 10.1152/ajpcell.00187.2016.
［32］	Sharma S, Goswami R, Zhang DX, et al. TRPV4 regulates matrix stiffness and TGFβ1⁃induced epithelial⁃mesenchymal transition［J］. J Cell Mol Med, 2019,23（2）:761⁃774. doi: 10.1111/jcmm. 13972.
［33］	Fusi C, Materazzi S, Minocci D, et al. Transient receptor potential vanilloid 4 （TRPV4） is downregulated in keratinocytes in human non⁃melanoma skin cancer［J］. J Invest Dermatol, 2014,134（9）:2408⁃2417. doi: 10.1038/jid.2014.145.
［34］	Ackermann K, Wallner S, Brochhausen C, et al. Expression profiles of ASIC1/2 and TRPV1/4 in common skin tumors［J］. Int J Mol Sci, 2021,22（11）:6024. doi: 10.3390/ijms22116024.
［35］	Olivan⁃Viguera A, Garcia⁃Otin AL, Lozano⁃Gerona J, et al. Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes［J/OL］. PLoS One, 2018,13（1）:e0190307. doi: 10.1371/journal.pone.0190307.
［36］	Li M, Zheng J, Wu T, et al. Activation of TRPV4 induces exocytosis and ferroptosis in human melanoma cells［J］. Int J Mol Sci, 2022,23（8）:4146. doi: 10.3390/ijms23084146.

[1]	Hao Feng, Liu Guoyan. Application of optical coherence tomography in dermatology [J]. Chinese Journal of Dermatology, 2024, 57(9): 853-857.
[2]	Zou Xianbiao, Chen Jinchun, Zeng Yue, Hao Yi. Application of ultrasonography in dermatology: progress and prospects [J]. Chinese Journal of Dermatology, 2024, 57(9): 785-790.
[3]	Zeng Yue, Shao Huihong, Lin Shiwen, Wen Rou, Zou Xianbiao. Application of a wearable teleconsultation device in diagnosis of common skin diseases [J]. Chinese Journal of Dermatology, 2024, 57(9): 797-800.
[4]	Zhang Jiaqi, Wu Fan, Han Yuqing, Liu Qi, Pan Yao. Application of multi-photon microscopy in dermatology [J]. Chinese Journal of Dermatology, 2024, 57(9): 857-862.
[5]	Wang Chen, Xue Chenhong, Song Jinghui, Li Jianguo, Li Zhenlu, Zhang Shoumin, Li Ming, Wang Jianbo. Adalimumab for the treatment of three cases of Blau syndrome in a pedigree [J]. Chinese Journal of Dermatology, 2024, 57(6): 553-556.
[6]	Jing Ke, Li Suo, Feng Suying. Clinical and immunoserological characteristics of 26 cases of linear IgA bullous dermatosis: a retrospective analysis [J]. Chinese Journal of Dermatology, 2024, 57(6): 503-509.
[7]	Han Yan, Xu Peng, Xiang Zhi, Jiang Tingting, Ge Fengqin, Yin Yueping, Chen Xiangsheng, . Strengthening research on prevention and treatment of chronic skin diseases — population medicine research program [J]. Chinese Journal of Dermatology, 2024, 57(6): 567-569.
[8]	Han Bing, Wang Hong, Liu Hesong, Li Shanshan. Exploration of the application of apremilast in various inflammatory skin diseases [J]. Chinese Journal of Dermatology, 2024, 0(3): 20240133-e20240133.
[9]	Gao Jinping, Zhang Xuejun, . Clinical application of baricitinib in dermatology [J]. Chinese Journal of Dermatology, 2024, 0(3): 20230528-e20230528.
[10]	Ye Hui, Xue Rujun, Zhang Xibao. Application of biological therapies and mechanisms of immunophenotypic switching in psoriasis and atopic dermatitis [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220795-e20220795.
[11]	Ma Tongchuan, Deng Tingyue, Xiao Fengli. Associations between smoking and atopic dermatitis [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220793-e20220793.
[12]	Liu Yingying, Deng Danqi. Correlations between skin microbiome and skin tumors [J]. Chinese Journal of Dermatology, 2024, 0(3): 20230241-e20230241.
[13]	Jiang Zhaoting, Jian Zhe. Application and prospect of artificial synthesized biomimetic polydopamine melanin nanoparticles in dermatology [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220567-e20220567.
[14]	Hong Yongzhen, Wang Qian, Liang Junqin, . Application of next-generation sequencing in the field of non-hereditary dermatoses [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220436-e20220436.
[15]	Liu Lyuye, Zhang Junling. Ferroptosis in common skin diseases [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220783-e20220783.

Role of transient receptor potential vanilloid type 4 channel in skin diseases

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［36］

Related Articles 15

Metrics

Comments

Recommended 10