microRNA在炎症性皮肤病中作用的研究进展

doi:10.35541/cjd.20190864

Abstract

Abstract: 【Abstract】 MicroRNAs (miRNAs) are a class of non-coding RNA molecules that regulate gene expression after transcription and participate in various pathophysiological processes in the skin. In recent years, it has been reported that changes in miRNA expression profiles are related to some inflammatory skin diseases. For example, miR-203, miR-146a and miR-21 are upregulated in psoriatic lesions, miR-155 and miR-146a are upregulated in atopic dermatitis lesions, miR-21, miR-223, miR-142-3p and miR142-5p are upregulated in allergic contact dermatitis lesions; however, miR-146a and miR-155 are downregulated in peripheral blood of patients with systemic lupus erythematosus, miR-223 is downregulated in dermatomyositis lesions. This review summarizes relationships of miRNAs with the occurrence and development of some inflammatory skin diseases.

Key words: MicroRNAs, Inflammation, Skin diseases

Ye Ruixian, Xue Rujun, Liang Jingyao, Liu Huanyan, Xiong Qiying, Dong Liangjiao, Zhang Xibao. Role of microRNAs in inflammatory skin diseases[J]. Chinese Journal of Dermatology, 2021, 54(2): 178-182.doi:10.35541/cjd.20190864

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Role of microRNAs in inflammatory skin diseases

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