microRNA在炎症性皮肤病中作用的研究进展

doi:10.35541/cjd.20190864

Abstract

Abstract: 【Abstract】 MicroRNAs (miRNAs) are a class of non-coding RNA molecules that regulate gene expression after transcription and participate in various pathophysiological processes in the skin. In recent years, it has been reported that changes in miRNA expression profiles are related to some inflammatory skin diseases. For example, miR-203, miR-146a and miR-21 are upregulated in psoriatic lesions, miR-155 and miR-146a are upregulated in atopic dermatitis lesions, miR-21, miR-223, miR-142-3p and miR142-5p are upregulated in allergic contact dermatitis lesions; however, miR-146a and miR-155 are downregulated in peripheral blood of patients with systemic lupus erythematosus, miR-223 is downregulated in dermatomyositis lesions. This review summarizes relationships of miRNAs with the occurrence and development of some inflammatory skin diseases.

Key words: MicroRNAs, Inflammation, Skin diseases

Ye Ruixian, Xue Rujun, Liang Jingyao, Liu Huanyan, Xiong Qiying, Dong Liangjiao, Zhang Xibao. Role of microRNAs in inflammatory skin diseases[J]. Chinese Journal of Dermatology, 2021, 54(2): 178-182.doi:10.35541/cjd.20190864

References ［35］

［1］	Deng X, Su Y, Wu H, et al. The role of microRNAs in autoimmune diseases with skin involvement［J］. Scand J Immunol, 2015,81（3）:153⁃165. doi: 10.1111/sji.12261.
［2］	Mannucci C, Casciaro M, Minciullo PL, et al. Involvement of microRNAs in skin disorders: a literature review［J］. Allergy Asthma Proc, 2017,38（1）:9⁃15. doi: 10.2500/aap.2017.38.4013.
［3］	Singhvi G, Manchanda P, Krishna Rapalli V, et al. MicroRNAs as biological regulators in skin disorders［J］. Biomed Pharmacother, 2018,108:996⁃1004. doi: 10.1016/j.biopha.2018. 09.090.
［4］	Chen JQ, Papp G, Szodoray P, et al. The role of microRNAs in the pathogenesis of autoimmune diseases［J］. Autoimmun Rev, 2016,15（12）:1171⁃1180. doi: 10.1016/j.autrev.2016.09.003.
［5］	Yi R, O′Carroll D, Pasolli HA, et al. Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs［J］. Nat Genet, 2006,38（3）:356⁃362. doi: 10.1038/ng1744.
［6］	Andl T, Murchison EP, Liu F, et al. The miRNA⁃processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles［J］. Curr Biol, 2006,16（10）:1041⁃1049. doi: 10.1016/j.cub.2006.04.005.
［7］	Jackson SJ, Zhang Z, Feng D, et al. Rapid and widespread suppression of self⁃renewal by microRNA⁃203 during epidermal differentiation［J］. Development, 2013,140（9）:1882⁃1891. doi: 10.1242/dev.089649.
［8］	Wei T, Orfanidis K, Xu N, et al. The expression of microRNA⁃203 during human skin morphogenesis［J］. Exp Dermatol, 2010,19（9）:854⁃856. doi: 10.1111/j.1600⁃0625.2010.01118.x.
［9］	Løvendorf MB, Skov L. miRNAs in inflammatory skin diseases and their clinical implications［J］. Expert Rev Clin Immunol, 2015,11（4）:467⁃477. doi: 10.1586/1744666X.2015.1020301.
［10］	Timis TL, Orasan RI. Understanding psoriasis: role of miRNAs［J］. Biomed Rep, 2018,9（5）:367⁃374. doi: 10.3892/br.2018. 1146.
［11］	Wang MJ, Xu YY, Huang RY, et al. Role of an imbalanced miRNAs axis in pathogenesis of psoriasis: novel perspectives based on review of the literature［J］. Oncotarget, 2017,8（3）:5498⁃5507. doi: 10.18632/oncotarget.12534.
［12］	Xu Y, Ji Y, Lan X, et al. miR⁃203 contributes to IL⁃17⁃induced VEGF secretion by targeting SOCS3 in keratinocytes［J］. Mol Med Rep, 2017,16（6）:8989⁃8996. doi: 10.3892/mmr.2017.7759.
［13］	Xu N, Meisgen F, Butler LM, et al. MicroRNA⁃31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40［J］. J Immunol, 2013,190（2）:678⁃688. doi: 10.4049/jimmunol.1202695.
［14］	Xu N, Brodin P, Wei T, et al. MiR⁃125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2［J］. J Invest Dermatol, 2011,131（7）:1521⁃1529. doi: 10.1038/jid.2011.55.
［15］	Meisgen F, Xu N, Wei T, et al. MiR⁃21 is up⁃regulated in psoriasis and suppresses T cell apoptosis［J］. Exp Dermatol, 2012,21（4）:312⁃314. doi: 10.1111/j.1600⁃0625.2012.01462.x.
［16］	Guinea⁃Viniegra J, Jiménez M, Schonthaler HB, et al. Targeting miR⁃21 to treat psoriasis［J］. Sci Transl Med, 2014,6（225）:225re1. doi: 10.1126/scitranslmed.3008089.
［17］	Masalha M, Sidi Y, Avni D. The contribution of feedback loops between miRNAs, cytokines and growth factors to the pathogenesis of psoriasis［J］. Exp Dermatol, 2018,27（6）:603⁃610. doi: 10.1111/exd.13520.
［18］	邓蕙妍, 林玲, 周欣, 等. 寻常型银屑病患者皮损miR⁃146a的表达及意义［J］. 中国中西医结合皮肤性病学杂志, 2016,15（3）:142⁃144. doi: 10.3969/j.issn.1672⁃0709.2016.03.004.
［19］	Park H, Huang X, Lu C, et al. MicroRNA⁃146a and microRNA⁃146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins［J］. J Biol Chem, 2015,290（5）:2831⁃2841. doi: 10.1074/jbc.M114.591420.
［20］	Xia P, Fang X, Zhang ZH, et al. Dysregulation of miRNA146a versus IRAK1 induces IL⁃17 persistence in the psoriatic skin lesions［J］. Immunol Lett, 2012,148（2）:151⁃162. doi: 10.1016/j.imlet.2012.09.004.
［21］	Sonkoly E, Janson P, Majuri ML, et al. MiR⁃155 is overexpressed in patients with atopic dermatitis and modulates T⁃cell proliferative responses by targeting cytotoxic T lymphocyte⁃associated antigen 4［J］. J Allergy Clin Immunol, 2010,126（3）:581⁃589.e1⁃20. doi: 10.1016/j.jaci.2010.05.045.
［22］	Ma L, Xue HB, Wang F, et al. MicroRNA⁃155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 （Th17） cells［J］. Clin Exp Immunol, 2015,181（1）:142⁃149. doi: 10.1111/cei.12624.
［23］	Rebane A, Runnel T, Aab A, et al. MicroRNA⁃146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes［J］. J Allergy Clin Immunol, 2014,134（4）:836⁃847.e11. doi: 10.1016/j.jaci.2014.05.022.
［24］	Yang Z, Zeng B, Wang C, et al. MicroRNA⁃124 alleviates chronic skin inflammation in atopic eczema via suppressing innate immune responses in keratinocytes［J］. Cell Immunol, 2017,319:53⁃60. doi: 10.1016/j.cellimm.2017.08.003.
［25］	Vennegaard MT, Bonefeld CM, Hagedorn PH, et al. Allergic contact dermatitis induces upregulation of identical microRNAs in humans and mice［J］. Contact Dermatitis, 2012,67（5）:298⁃305. doi: 10.1111/j.1600⁃0536.2012.02083.x.
［26］	Gulati N, Løvendorf MB, Zibert JR, et al. Unique microRNAs appear at different times during the course of a delayed⁃type hypersensitivity reaction in human skin［J］. Exp Dermatol, 2015,24（12）:953⁃957. doi: 10.1111/exd.12813.
［27］	Pivarcsi A, Meisgen F, Xu N, et al. Changes in the level of serum microRNAs in patients with psoriasis after antitumour necrosis factor⁃α therapy［J］. Br J Dermatol, 2013,169（3）:563⁃570. doi: 10.1111/bjd.12381.
［28］	Løvendorf MB, Mitsui H, Zibert JR, et al. Laser capture microdissection followed by next⁃generation sequencing identifies disease⁃related microRNAs in psoriatic skin that reflect systemic microRNA changes in psoriasis［J］. Exp Dermatol, 2015,24（3）:187⁃193. doi: 10.1111/exd.12604.
［29］	Qu B, Cao J, Zhang F, et al. Type I interferon inhibition of microRNA⁃146a maturation through up⁃regulation of monocyte chemotactic protein⁃induced protein 1 in systemic lupus erythematosus［J］. Arthritis Rheumatol, 2015,67（12）:3209⁃3218. doi: 10.1002/art.39398.
［30］	Tang Y, Luo X, Cui H, et al. MicroRNA⁃146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins［J］. Arthritis Rheum, 2009,60（4）:1065⁃1075. doi: 10.1002/art.24436.
［31］	杜明, 陶李, 王昱斌, 等. SLE患者外周血单个核细胞中miR⁃148b、miR⁃152和靶基因dnmt1的表达及其临床意义［J］. 免疫学杂志, 2018,34（11）:966⁃971+983.
［32］	Lashine YA, Salah S, Aboelenein HR, et al. Correcting the expression of miRNA⁃155 represses PP2Ac and enhances the release of IL⁃2 in PBMCs of juvenile SLE patients［J］. Lupus, 2015,24（3）:240⁃247. doi: 10.1177/0961203314552117.
［33］	Mizui M, Tsokos GC. Low⁃dose IL⁃2 in the treatment of lupus［J］. Curr Rheumatol Rep, 2016,18（11）:68. doi: 10.1007/s11926⁃016⁃0617⁃5.
［34］	Inoue K, Jinnin M, Yamane K, et al. Down⁃regulation of miR⁃223 contributes to the formation of Gottron′s papules in dermatomyositis via the induction of PKCɛ［J］. Eur J Dermatol, 2013,23（2）:160⁃167. doi: 10.1684/ejd.2013.1959.
［35］	Hirai T, Ikeda K, Tsushima H, et al. Circulating plasma microRNA profiling in patients with polymyositis/dermatomyositis before and after treatment: miRNA may be associated with polymyositis/dermatomyositis［J］. Inflamm Regen, 2018,38:1. doi: 10.1186/s41232⁃017⁃0058⁃1.

[1]	Zhang Guoyi, Gong Xiangdong, Zhu Bokun, Liu Chuanxia, Jing Linghua, Xu Jinyu. Patterns of skin diseases among outpatients attending Hospital of Dermatology of Chinese Academy of Medical Sciences in 2019 [J]. Chinese Journal of Dermatology, 2022, 55(2): 150-152.
[2]	Jiang Peiyu, Zhang Jiawen, Liu Zijing, Wang Xiaoyan, Liu Yunyi, Liu Yixuan, Xu Yang. Basic principles of photobiomodulation and its application in dermatology [J]. Chinese Journal of Dermatology, 2022, 55(1): 84-87.
[3]	Chinese Society of Dermatology, China Dermatologist Association. Consensus on the diagnosis and treatment of autoimmune subepidermal bullous diseases （2022） [J]. Chinese Journal of Dermatology, 2022, 55(1): 1-11.
[4]	Long Hai, Jiang Li, Qiu Yueqi, Yao Nan, Liu Licong, Xie Yuming, Xiong Feng, Tan Siqi, Kuang Qiqi, You Ruixuan, Chai Ke, Luo Xin, Long Haojun, Xin Yue, Guo Ziyu, Wang Jiaqi, Tan Yixin, Zhang Qing, Zhang Guiying, Li Yaping, Su Yuwen, Xiao Rong, Lu Qianjin, . Clinical analysis of 1 057 patients with critical illnesses in a dermatological ward [J]. Chinese Journal of Dermatology, 2021, 54(9): 790-797.
[5]	Autoimmune Disease Group, China Dermatologist Association. Chinese expert consensus on cyclophosphamide for the treatment of autoimmune dermatoses [J]. Chinese Journal of Dermatology, 2021, 54(9): 765-770.
[6]	Lin Luyang, Chen Zhengliang, Zhang Xibao. Major immune-related cells in psoriasis vulgaris lesions [J]. Chinese Journal of Dermatology, 2021, 54(9): 830-834.
[7]	Hu Feng, Chen Liuqing, Wang Wei, Zheng Fang. Epidemiological characteristics and disease spectrum analysis of outpatients in the dermatology department of a hospital in Wuhan during the COVID-19 epidemic [J]. Chinese Journal of Dermatology, 2021, 54(8): 719-722.
[8]	Zhang Haini, Kou Caixia, Liu Jinquan, Zhang Ruihua, Ma Yinni, Zhang Ruili, Wang Qianqiu. Inductive effect of Treponema pallidum on macrophage polarization [J]. Chinese Journal of Dermatology, 2021, 54(8): 688-695.
[9]	. Role and action mechanism of microRNA-26a targeting EZH2 in ultraviolet A-induced photoaging of human skin fibroblasts [J]. Chinese Journal of Dermatology, 2021, 54(7): 612-619.
[10]	Ying Jieya, Xiang Wenzhong, Song Xiuzu. Metabolic syndrome and skin diseases [J]. Chinese Journal of Dermatology, 2021, 54(7): 642-645.
[11]	Su Fang, Jin Liang, Li Hao, Ding Yingjie, Sun Xiaojie, Sun Xiaodong, Liu Wei, Xu Guijuan, Wang Qiang, Liu Yongbin. Mechanisms underlying microRNA-125a-mediated inhibition of proliferation of HaCaT cells by targeting the interleukin 23 receptor signaling pathway: a preliminary study [J]. Chinese Journal of Dermatology, 2021, 54(6): 499-503.
[12]	Committee on Autoimmune Diseases, China Dermatologist Association. Expert consensus on methotrexate in the treatment of immune-associated dermatoses [J]. Chinese Journal of Dermatology, 2021, 54(5): 382-390.
[13]	Yang Ting, Zhang Kaoyuan, Li Zizhuo, Li Xu, Yu Bo, Dou Xia. Role of group 2 innate lymphoid cells in mice with atopic dermatitis-like inflammatory response induced by MC903 [J]. Chinese Journal of Dermatology, 2021, 54(4): 335-341.
[14]	Li Jian, Song Zhiqiang. New insights into facial flushing and erythema in rosacea [J]. Chinese Journal of Dermatology, 2021, 54(4): 360-363.
[15]	Liu Pei, Shi Lei, Wang Xiuli. Selection of light sources and radiation parameters in photodynamic therapy for skin diseases [J]. Chinese Journal of Dermatology, 2021, 54(11): 1015-1018.

Role of microRNAs in inflammatory skin diseases

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［35］

Related Articles 15

Metrics

Comments

Recommended 10