牙周炎与免疫性皮肤病的研究进展

doi:10.35541/cjd.20230059

Abstract

Abstract: 【Abstract】 Periodontitis is a chronic inflammatory disease triggered by bacterial infections that activate the host′s immune response, thereby destroying supporting tissues of the teeth, forming periodontal pockets, and eventually leading to tooth loss. Recent studies have found periodontitis is associated with a variety of immune skin diseases, and there may be a bidirectional relationship as well. This review summarizes the association between periodontitis and immune skin diseases.

Key words: Periodontitis, Skin diseases, Epidemiology, Risk factors

Yang Xiaoli, Deng Danqi. Periodontitis and immune skin diseases[J]. Chinese Journal of Dermatology,2023,e20230059. doi:10.35541/cjd.20230059

References ［40］

［1］	Zhang X, Gu H, Xie S, et al. Periodontitis in patients with psoriasis: a systematic review and meta⁃analysis［J］. Oral Dis, 2022,28（1）:33⁃43. doi: 10.1111/odi.13617.
［2］	Feng Y, Chen Z, Tu SQ, et al. Role of interleukin⁃17A in the pathomechanisms of periodontitis and related systemic chronic inflammatory diseases［J］. Front Immunol, 2022,13:862415. doi: 10.3389/fimmu.2022.862415.
［3］	Liang Y, Shao JL, Ge SH. Research advances in the interaction of periodontitis and psoriasis［J］. Zhonghua Kou Qiang Yi Xue Za Zhi, 2021,56（6）:591⁃597. doi: 10.3760/cma.j.cn112144⁃20210128⁃00043.
［4］	Wu KJ, Tu CC, Hu JX, et al. Severity of periodontitis and salivary interleukin⁃1β are associated with psoriasis involvement［J］. J Formos Med Assoc, 2022,121（10）:1908⁃1916. doi: 10.1016/j.jfma.2022.01.017.
［5］	Qiao P, Shi Q, Zhang R, et al. Psoriasis patients suffer from worse periodontal status⁃a meta⁃analysis［J］. Front Med（Lausanne）, 2019,6:212. doi: 10.3389/fmed.2019.00212.
［6］	Barros FC, Sampaio JN, Figueredo C, et al. Higher prevalence of periodontitis and decayed, missing and filled teeth in patients with psoriasis［J］. Eur J Dent, 2020,14（3）:366⁃370. doi: 10. 1055/s⁃0040⁃1713465.
［7］	Mendes VS, Cota L, Costa AA, et al. Periodontitis as another comorbidity associated with psoriasis: a case⁃control study［J］. J Periodontol, 2019,90（4）:358⁃366. doi: 10.1002/JPER.18⁃0394.
［8］	Nijakowski K, Gruszczyński D, Kolasińska J, et al. Periodontal disease in patients with psoriasis: a systematic review［J］. Int J Environ Res Public Health, 2022,19（18）:11302. doi: 10.3390/ijerph191811302.
［9］	Baurecht H, Freuer D, Welker C, et al. Relationship between periodontitis and psoriasis: a two⁃sample Mendelian randomization study［J］. J Clin Periodontol, 2022,49（6）:573⁃579. doi: 10.1111/jcpe.13620.
［10］	Smirnova J, Montgomery S, Lindberg M, et al. Associations of self⁃reported atopic dermatitis with comorbid conditions in adults: a population⁃based cross⁃sectional study［J］. BMC Dermatol, 2020,20（1）:23. doi: 10.1186/s12895⁃020⁃00117⁃8.
［11］	Tursas L, Ylipalosaari M, Sinikumpu SP, et al. Association between bleeding periodontal pockets and eczemas: results of the Northern Finland Birth Cohort 1966［J］. J Clin Periodontol, 2022,49（6）:591⁃598. doi: 10.1111/jcpe.13614.
［12］	张力木, 林晓萍. 牙周炎与系统性红斑狼疮相关性研究进展［J］. 口腔医学, 2020,40（9）:833⁃838. doi:10.13591/j.cnki.kqyx. 2020.09.013.
［13］	Sojod B, Pidorodeski Nagano C, Garcia Lopez GM, et al. Systemic lupus erythematosus and periodontal disease: a complex clinical and biological interplay［J］. J Clin Med, 2021,10（9）:1957. doi: 10.3390/jcm10091957.
［14］	Aurlene N, Manipal S, Prabu D, et al. Prevalence of oral mucosal lesions, dental caries, and periodontal disease among patients with systemic lupus erythematosus in a teaching hospital in Chennai, Tamil Nadu［J］. J Family Med Prim Care, 2020,9（7）:3374⁃3380. doi: 10.4103/jfmpc.jfmpc_1263_19.
［15］	Zhong HJ, Xie HX, Luo XM, et al. Association between periodontitis and systemic lupus erythematosus: a meta⁃analysis［J］. Lupus, 2020,29（10）:1189⁃1197. doi: 10.1177/096120332 0938447.
［16］	Bolstad AI, Sehjpal P, Lie SA, et al. Periodontitis in patients with systemic lupus erythematosus: a nationwide study of 1 990 patients［J］. J Periodontol, 2022,93（3）:364⁃372. doi: 10.1002/JPER.21⁃0181.
［17］	Zhang LM, Wang Y, Qi S, et al. Expression of B cell activation factor and correlation analysis in patients of systemic lupus erythematosus and its correlation with periodontitis［J］. Shanghai Kou Qiang Yi Xue, 2022,31（2）:178⁃183.
［18］	Bae SC, Lee YH. Causal association between periodontitis and risk of rheumatoid arthritis and systemic lupus erythematosus: a Mendelian randomization［J］. Z Rheumatol, 2020,79（9）:929⁃936. doi: 10.1007/s00393⁃019⁃00742⁃w.
［19］	Zamora⁃Pasadas M, Marfil⁃Álvarez R, González⁃Bustos P, et al. Periodontitis is associated with higher subclinical atherosclerosis in patients with systemic lupus erythematosus［J］. J Periodontal Res, 2022,57（3）:479⁃486. doi: 10.1111/jre.12977.
［20］	Zhang S, Zhu J, Zhu Y, et al. Oral manifestations of patients with systemic sclerosis: a meta⁃analysis for case⁃controlled studies［J］. BMC Oral Health, 2021,21（1）:250. doi: 10.1186/s12903⁃021⁃01603⁃2.
［21］	Gomes da Silva GS, Maymone de Melo ML, Leão JC, et al. Oral features of systemic sclerosis: a case⁃control study［J］. Oral Dis, 2019,25（8）:1995⁃2002. doi: 10.1111/odi.13174.
［22］	Isola G, Palazzo G, Polizzi A, et al. Association of systemic sclerosis and periodontitis with vitamin D levels［J］. Nutrients, 2021,13（2）:705. doi: 10.3390/nu13020705.
［23］	Jascholt I, Lai O, Zillikens D, et al. Periodontitis in oral pemphigus and pemphigoid: a systematic review of published studies［J］. J Am Acad Dermatol, 2017,76（5）:975⁃978.e3. doi: 10.1016/j.jaad.2016.10.028.
［24］	Macklis P, Adams K, Kaffenberger J, et al. The association between oral health and skin disease［J］. J Clin Aesthet Dermatol, 2020,13（6）:48⁃53.
［25］	刘好好, 宋忠臣. 牙周炎与口腔黏膜病相关性的研究进展［J］. 口腔生物医学, 2019,10（2）:101⁃104. doi: 10.3969/j.issn. 1674⁃8603.2019.02.010.
［26］	Mumcu G, Fortune F. Oral health and its aetiological role in Behçet′s disease［J］. Front Med（Lausanne）, 2021,8:613419. doi: 10.3389/fmed.2021.613419.
［27］	Khemiss M, Hajjaj S, Blouza I, et al. Oral manifestations of Behçet′s disease［J］. Tunis Med, 2022,100（4）:303⁃308.
［28］	Senusi A, Higgins S, Fortune F. The influence of oral health and psycho⁃social well⁃being on clinical outcomes in Behçet′s disease［J］. Rheumatol Int, 2018,38（10）:1873⁃1883. doi: 10. 1007/s00296⁃018⁃4117⁃y.
［29］	Nunes GP, Pirovani BO, Nunes LP, et al. Does oral lichen planus aggravate the state of periodontal disease? A systematic review and meta⁃analysis［J］. Clin Oral Investig, 2022,26（4）:3357⁃3371. doi: 10.1007/s00784⁃022⁃04387⁃z.
［30］	邱澈, 宋忠臣. 慢性牙周炎与口腔扁平苔藓相关性研究进展［J］. 口腔医学, 2019,39（12）:1144⁃1148. doi: 10.13591/j.cnki.kqyx.2019.12.020.
［31］	Yay M, Çelik Z, Aksoy A, et al. Oral health is a mediator for disease severity in patients with Behçet′s disease: a multiple mediation analysis study［J］. J Oral Rehabil, 2019,46（4）:349⁃354. doi: 10.1111/joor.12750.
［32］	Liu H, Chen H, Liao Y, et al. Comparative analyses of the subgingival microbiome in chronic periodontitis patients with and without gingival erosive oral lichen planus based on 16S rRNA gene sequencing［J］. Biomed Res Int, 2021,2021:9995225. doi: 10.1155/2021/9995225.
［33］	Abriani A, Hamad C. Activated antimicrobial peptides due to periodontal bacteria in synovial fluid ⁃ the link between psoriatic arthritis and periodontitis?［J］. Med Hypotheses, 2020,144:109967. doi: 10.1016/j.mehy.2020.109967.
［34］	Uchiyama J, Osumi T, Mizukami K, et al. Characterization of the oral and faecal microbiota associated with atopic dermatitis in dogs selected from a purebred Shiba Inu colony［J］. Lett Appl Microbiol, 2022,75（6）:1607⁃1616. doi: 10.1111/lam.13828.
［35］	Marques C, Rodrigues VP, de Carvalho LC, et al. Expression of Toll⁃like receptors 2 and 4 in the saliva of patients with systemic lupus erythematosus and chronic periodontitis［J］. Clin Rheumatol, 2021,40（7）:2727⁃2734. doi: 10.1007/s10067⁃020⁃05560⁃z.
［36］	Morikawa S, Ouchi T, Asoda S, et al. Treatment of severe generalized chronic periodontitis in a patient with Behçet′s disease: a case report［J］. J Int Med Res, 2018,46（5）:2037⁃2045. doi: 10.1177/0300060518762267.
［37］	Ucan Yarkac F, Ogrum A, Gokturk O. Effects of non⁃surgical periodontal therapy on inflammatory markers of psoriasis: a randomized controlled trial［J］. J Clin Periodontol, 2020,47（2）:193⁃201. doi: 10.1111/jcpe.13205.
［38］	Maybodi FR, Bashiri H, Sezavar K, et al. Effect of periodontal treatment on serum inflammatory parameters and disease activity in patients with systemic lupus erythematosus: a randomized controlled trial［J］. J Indian Soc Periodontol, 2022,26（6）:564⁃569. doi: 10.4103/jisp.jisp_607_21.
［39］	Sakunrangsit N, Metheepakornchai P, Kumpunya S, et al. Etanercept prevents TNF⁃α mediated mandibular bone loss in FcγRIIb-/- lupus model［J/OL］. PLoS One, 2021,16（4）:e0250215. doi: 10.1371/journal.pone.0250215.
［40］	Storrer C, Rigo Junior D, Teixeira L, et al. Benign mucosal membrane pemphigoid as a differential diagnosis of necrotizing periodontal disease［J］. Case Rep Dent, 2020,2020:8885158. doi: 10.1155/2020/8885158.

[1]	Zhang Jiaqi, Wu Fan, Han Yuqing, Liu Qi, Pan Yao. Application of multi-photon microscopy in dermatology [J]. Chinese Journal of Dermatology, 2024, 57(9): 857-862.
[2]	Zou Xianbiao, Chen Jinchun, Zeng Yue, Hao Yi. Application of ultrasonography in dermatology: progress and prospects [J]. Chinese Journal of Dermatology, 2024, 57(9): 785-790.
[3]	Zeng Yue, Shao Huihong, Lin Shiwen, Wen Rou, Zou Xianbiao. Application of a wearable teleconsultation device in diagnosis of common skin diseases [J]. Chinese Journal of Dermatology, 2024, 57(9): 797-800.
[4]	Hao Feng, Liu Guoyan. Application of optical coherence tomography in dermatology [J]. Chinese Journal of Dermatology, 2024, 57(9): 853-857.
[5]	Wei-Qi REN Ya-Ru ZOU Min PAN. Risk factors for secondary infection in patients with bullous pemphigoid [J]. Chinese Journal of Dermatology, 2024, 57(8): 770-772.
[6]	Wang Chen, Xue Chenhong, Song Jinghui, Li Jianguo, Li Zhenlu, Zhang Shoumin, Li Ming, Wang Jianbo. Adalimumab for the treatment of three cases of Blau syndrome in a pedigree [J]. Chinese Journal of Dermatology, 2024, 57(6): 553-556.
[7]	Jing Ke, Li Suo, Feng Suying. Clinical and immunoserological characteristics of 26 cases of linear IgA bullous dermatosis: a retrospective analysis [J]. Chinese Journal of Dermatology, 2024, 57(6): 503-509.
[8]	Han Yan, Xu Peng, Xiang Zhi, Jiang Tingting, Ge Fengqin, Yin Yueping, Chen Xiangsheng, . Strengthening research on prevention and treatment of chronic skin diseases — population medicine research program [J]. Chinese Journal of Dermatology, 2024, 57(6): 567-569.
[9]	Jiang Zhaoting, Jian Zhe. Application and prospect of artificial synthesized biomimetic polydopamine melanin nanoparticles in dermatology [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220567-e20220567.
[10]	Hong Yongzhen, Wang Qian, Liang Junqin, . Application of next-generation sequencing in the field of non-hereditary dermatoses [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220436-e20220436.
[11]	Yang Siyan, Ma Lin, Zhang Bin. Application of crisaborole ointment in dermatology [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220709-e20220709.
[12]	Liu Lyuye, Zhang Junling. Ferroptosis in common skin diseases [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220783-e20220783.
[13]	Wu Chengyu, Wang Peng, Kang Xiaojing. Identification and typing of Kaposi′s sarcoma-associated herpesvirus [J]. Chinese Journal of Dermatology, 2024, 57(3): 275-278.
[14]	Na Jun, Li Ruoyu, Zhong Shaomin, Yang Li, Wu Yan. Diagnosis and treatment of rosacea in the real world: a survey on the current status [J]. Chinese Journal of Dermatology, 2024, 57(2): 127-133.
[15]	Guo Lei, Cao Chunyan, Fang Xiaoya, Feng Suying. Analysis of current status and risk factors of multidrug-resistant bacteria wound infections in patients with autoimmune bullous diseases [J]. Chinese Journal of Dermatology, 2024, 57(2): 155-160.

Periodontitis and immune skin diseases

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［40］

Related Articles 15

Metrics

Comments

Recommended 10