Mas相关G蛋白偶联受体X2在特应性皮炎瘙痒中的研究进展

doi:10.35541/cjd.20230078

Abstract

Abstract: 【Abstract】 Atopic dermatitis is a chronic recurrent inflammatory skin disease, and often accompanied by severe itch, which greatly affects the quality of life of patients. Mas-related G protein-coupled receptor X2 is a multi-ligand receptor highly expressed on mast cells. It can respond to a variety of exogenous and endogenous stimuli, trigger mast cell degranulation and promote inflammatory mediator release through various signaling cascades, and play an important role in the occurrence and development of atopic dermatitis. This review summarizes current understanding on mechanisms of action of Mas-related G protein-coupled receptor X2 in atopic dermatitis-associated itch, as wellas related drug inhibitors, in order to provide a theoretical basis for the treatment of atopic dermatitis-associated itch.

Key words: Dermatitis, atopic, Pruritus, Mast cells, MRGPRX2, Signal transduction

Yang Lei, Zheng Gaofeng, Chu Lei, Ran Yuping. Mas-related G protein-coupled rceptor X2 in itch in atopic dermatitis[J]. Chinese Journal of Dermatology,2023,e0230078. doi:10.35541/cjd.20230078

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Mas-related G protein-coupled rceptor X2 in itch in atopic dermatitis

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