胸腺基质淋巴细胞生成素在不同皮肤病中的作用机制研究

doi:10.35541/cjd.20191098

Abstract

Abstract: 【Abstract】 Thymic stromal lymphopoietin （TSLP）, a cytokine similar to interleukin-7 （IL-7）, can promote the differentiation and proliferation of a variety of cells, promote the secretion of Th2 cytokines by these cells, and plays an important role in the immune system. In recent years, abnormal expression of TSLP has been found in many skin diseases, and its level is also related to the severity of some skin diseases, suggesting that TSLP may be a potential target for the treatment of various skin diseases. This review summarizes recent research progress in the role of TSLP in the occurrence and development of various skin diseases, including inflammatory diseases, immune diseases, genetic diseases and tumors, and provides a basis and ideas for the diagnosis and treatment of related diseases.

Key words: Interleukin-7, Dermatitis, atopic, Psoriasis, Pemphigoid, bullous, Netherton syndrome, Epidermolysis bullosa simplex, Skin neoplasms, Thymic stromal lymphopoietin

Jin Xinxing, Li Sizhe, Zuo Yagang. Role of thymic stromal lymphopoietin in various skin diseases[J]. Chinese Journal of Dermatology, 2021, 54(10): 915-919.doi:10.35541/cjd.20191098

References ［33］

［1］	Ying G, Zhang Y, Tang G, et al. Functions of thymic stromal lymphopoietin in non⁃allergic diseases［J］. Cell Immunol, 2015,295（2）:144⁃149. doi: 10.1016/j.cellimm.2015.03.006.
［2］	Park JH, Jeong DY, Peyrin⁃Biroulet L, et al. Insight into the role of TSLP in inflammatory bowel diseases［J］. Autoimmun Rev, 2017,16（1）:55⁃63. doi: 10.1016/j.autrev.2016.09.014.
［3］	Zhang Y, Zhou B. Functions of thymic stromal lymphopoietin in immunity and disease［J］. Immunol Res, 2012,52（3）:211⁃223. doi: 10.1007/s12026⁃012⁃8264⁃z.
［4］	Gago⁃Lopez N, Mellor LF, Megías D, et al. Role of bulge epidermal stem cells and TSLP signaling in psoriasis［J］. EMBO Mol Med, 2019,11（11）:e10697. doi: 10.15252/emmm.201910697.
［5］	Zhang Y, Hwang BJ, Liu Z, et al. BP180 dysfunction triggers spontaneous skin inflammation in mice［J］. Proc Natl Acad Sci U S A, 2018,115（25）:6434⁃6439. doi: 10.1073/pnas.1721805115.
［6］	Bjerkan L, Schreurs O, Engen SA, et al. The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide［J］. Mucosal Immunol, 2015,8（1）:49⁃56. doi: 10.1038/mi.2014.41.
［7］	Varricchi G, Pecoraro A, Marone G, et al. Thymic stromal lymphopoietin isoforms, inflammatory disorders, and cancer［J］. Front Immunol, 2018,9:1595. doi: 10.3389/fimmu.2018.01595.
［8］	Kumar V, Behr M, Kiritsi D, et al. Keratin⁃dependent thymic stromal lymphopoietin expression suggests a link between skin blistering and atopic disease［J］. J Allergy Clin Immunol, 2016,138（5）:1461⁃1464.e6. doi: 10.1016/j.jaci.2016.04.046.
［9］	Anderson SE, Baur R, Kashon M, et al. Potential classification of chemical immunologic response based on gene expression profiles［J］. J Immunotoxicol, 2020,17（1）:122⁃134. doi: 10.1080/1547691X.2020.1758855.
［10］	Ziegler SF, Roan F, Bell BD, et al. The biology of thymic stromal lymphopoietin （TSLP）［J］. Adv Pharmacol, 2013,66:129⁃155. doi: 10.1016/B978⁃0⁃12⁃404717⁃4.00004⁃4.
［11］	Kummola L, Ortutay Z, Chen X, et al. IL⁃7Rα expression regulates murine dendritic cell sensitivity to thymic stromal lymphopoietin［J］. J Immunol, 2017,198（10）:3909⁃3918. doi: 10.4049/jimmunol.1600753.
［12］	Arima K, Watanabe N, Hanabuchi S, et al. Distinct signal codes generate dendritic cell functional plasticity［J］. Sci Signal, 2010,3（105）:ra4. doi: 10.1126/scisignal.2000567.
［13］	Inagaki⁃Katashiba N, Ito T, Inaba M, et al. Statins can suppress DC⁃mediated Th2 responses through the repression of OX40⁃ligand and CCL17 expression［J］. Eur J Immunol, 2019,49（11）:2051⁃2062. doi: 10.1002/eji.201847992.
［14］	Hui CC, Murphy DM, Neighbour H, et al. T cell⁃mediated induction of thymic stromal lymphopoietin in differentiated human primary bronchial epithelial cells［J］. Clin Exp Allergy, 2014,44（7）:953⁃964. doi: 10.1111/cea.12330.
［15］	Pattarini L, Trichot C, Bogiatzi S, et al. TSLP⁃activated dendritic cells induce human T follicular helper cell differentiation through OX40⁃ligand［J］. J Exp Med, 2017,214（5）:1529⁃1546. doi: 10.1084/jem.20150402.
［16］	Imai Y. Interleukin⁃33 in atopic dermatitis ［J］. J Dermatol Sci, 2019,96（1）:2⁃7. doi: 10.1016/j.jdermsci.2019.08.006.
［17］	Kitajima M, Kubo M, Ziegler SF, et al. Critical role of TSLP receptor on CD4 T cells for exacerbation of skin inflammation［J］. J Immunol, 2020,205（1）:27⁃35. doi: 10.4049/jimmunol.190 0758.
［18］	Lou C, Mitra N, Wubbenhorst B, et al. Association between fine mapping thymic stromal lymphopoietin and atopic dermatitis onset and persistence［J］. Ann Allergy Asthma Immunol, 2019,123（6）:595⁃601.e1. doi: 10.1016/j.anai.2019.08.018.
［19］	Sawada Y, Honda T, Nakamizo S, et al. Prostaglandin E2 （PGE2）⁃EP2 signaling negatively regulates murine atopic dermatitis⁃like skin inflammation by suppressing thymic stromal lymphopoietin expression［J］. J Allergy Clin Immunol, 2019,144（5）:1265⁃1273.e9. doi: 10.1016/j.jaci.2019.06.036.
［20］	李玉娟, 江勇, 李慧卿, 等. 窄谱中波紫外线对特应性皮炎患者外周血血清胸腺基质淋巴细胞生成素、白细胞介素25及其受体的影响［J］. 中华皮肤科杂志, 2015,48（8）:551⁃554. doi: 10.3760/cma.j.issn.0412⁃4030.2015.08.008.
［21］	Moon PD, Han NR, Lee JS, et al. Use of physcion to improve atopic dermatitis⁃like skin lesions through blocking of thymic stromal lymphopoietin［J］. Molecules, 2019,24（8）:1484. doi: 10.3390/molecules24081484.
［22］	Simpson EL, Parnes JR, She D, et al. Tezepelumab, an anti⁃thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: a randomized phase 2a clinical trial［J］. J Am Acad Dermatol, 2019,80（4）:1013⁃1021. doi: 10.1016/j.jaad.2018.11.059.
［23］	Chu CY. Treatments for childhood atopic dermatitis: an update on emerging therapies［J］. Clin Rev Allergy Immunol, 2020.（2020⁃06⁃20）［2020⁃07⁃10］. https://link.springer.com/article/10.1007/s12016⁃020⁃08799⁃1. doi: 10.1007/s12016⁃020⁃08799⁃1.
［24］	Volpe E, Pattarini L, Martinez⁃Cingolani C, et al. Thymic stromal lymphopoietin links keratinocytes and dendritic cell⁃derived IL⁃23 in patients with psoriasis［J］. J Allergy Clin Immunol, 2014,134（2）:373⁃381. doi: 10.1016/j.jaci.2014.04.022.
［25］	Sato⁃Deguchi E, Imafuku S, Chou B, et al. Topical vitamin D3 analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions［J］. Br J Dermatol, 2012,167（1）:77⁃84. doi: 10.1111/j.1365⁃2133.2012.10917.x.
［26］	Elmasry MF, Nagui N, Rashed LA, et al. Cutaneous expression of thymic stromal lymphopoietin （TSLP） in vitiligo patients: a case⁃control study［J］. Int J Dermatol, 2019,58（5）:589⁃592. doi: 10.1111/ijd.14282.
［27］	Cheong KA, Chae SC, Kim YS, et al. Association of thymic stromal lymphopoietin gene ⁃847C>T polymorphism in generalized vitiligo［J］. Exp Dermatol, 2009,18（12）:1073⁃1075. doi: 10.1111/j.1600⁃0625.2009.00897.x.
［28］	Briot A, Deraison C, Lacroix M, et al. Kallikrein 5 induces atopic dermatitis⁃like lesions through PAR2⁃mediated thymic stromal lymphopoietin expression in Netherton syndrome［J］. J Exp Med, 2009,206（5）:1135⁃1147. doi: 10.1084/jem.20082242.
［29］	Zingkou E, Pampalakis G, Charla E, et al. A proinflammatory role of KLK6 protease in Netherton syndrome［J］. J Dermatol Sci, 2019,95（1）:28⁃35. doi: 10.1016/j.jdermsci.2019.06.004.
［30］	Di Piazza M, Nowell CS, Koch U, et al. Loss of cutaneous TSLP⁃dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting［J］. Cancer Cell, 2012,22（4）:479⁃493. doi: 10.1016/j.ccr.2012.08.016.
［31］	Demehri S, Turkoz A, Manivasagam S, et al. Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin［J］. Cancer Cell, 2012,22（4）:494⁃505. doi: 10.1016/j.ccr.2012.08.017.
［32］	Takahashi N, Sugaya M, Suga H, et al. Thymic stromal chemokine TSLP acts through Th2 cytokine production to induce cutaneous T⁃cell lymphoma［J］. Cancer Res, 2016,76（21）:6241⁃6252. doi: 10.1158/0008⁃5472.CAN⁃16⁃0992.
［33］	Tuzova M, Richmond J, Wolpowitz D, et al. CCR4+ T cell recruitment to the skin in mycosis fungoides: potential contributions by thymic stromal lymphopoietin and interleukin⁃16 ［J］. Leuk Lymphoma, 2015,56（2）:440⁃449. doi: 10.3109/10428194.2014.919634.

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Role of thymic stromal lymphopoietin in various skin diseases

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