Chinese Journal of Dermatology ›› 2022, e20210420.doi: 10.35541/cjd.20210420

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Paradoxical psoriasis induced by tumor necrosis factor-α inhibitors and other biological agents

Lu Jiawei, Lu Yan   

  1. Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2021-06-01 Revised:2021-09-09 Online:2022-01-01 Published:2022-02-08
  • Contact: Lu Yan
  • Supported by:
    National Natural Science Foundation of China(81872541)

Abstract: 【Abstract】 Tumor necrosis factor(TNF)-α inhibitors have become an important choice for patients with chronic inflammatory diseases who were intolerant or poorly responsive to conventional therapies. Studies have shown that psoriasis can develop or be exacerbated in 2% - 5% of patients treated with TNF-α inhibitors, and this phenomenon is called paradoxical psoriasis. Paradoxical psoriasis and classic psoriasis have similar clinical manifestations, but different immunological mechanisms. This review summarizes the pathogenesis, clinicopathological features and management of paradoxical psoriasis, and provides an overview of paradoxical psoriasis following the application of other common biological agents.

Key words: Psoriasis, Tumor necrosis factor-alpha, Biological agents, Drug toxicity, Paradoxical psoriasis