脂质组学在痤疮皮脂分析中的应用

doi:10.35541/cjd.20190535

中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (10): 853-856.doi: 10.35541/cjd.20190535

• 综述 • 上一篇

脂质组学在痤疮皮脂分析中的应用

魏露¹ 朱明芳¹ 鞠强²

¹湖南中医药大学第二附属医院皮肤科，长沙 410005；²上海交通大学医学院附属仁济医院皮肤科 200127

收稿日期:2019-04-28 修回日期:2019-12-30 发布日期:2020-09-30
通讯作者: 朱明芳 E-mail:26715858@qq.com
基金资助:
湖南省教育厅科学研究项目（18A212）；湖南省临床医疗技术创新引导项目（2018SK51102）；湖南省研究生科研创新项目（CX2018B501）；湖南省高层次卫生人才“225”工程培养项目

Application of lipidomics in the analysis of sebum in acne patients

Wei Lu¹, Zhu Mingfang¹, Ju Qiang²

¹Department of Dermatology, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, China; ²Department of Dermatology, Renji Hospital, School of Medicine，Shanghai Jiaotong University, Shanghai 200127, China

Received:2019-04-28 Revised:2019-12-30 Published:2020-09-30
Contact: Zhu Mingfang E-mail:26715858@qq.com
Supported by:
Scientific Research Project of Hunan Education Department （18A212）; Clinical Medical Technology Innovation Guidance Project of Hunan Province （2018SK51102）; Hunan Postgraduate Research and Innovation Project （CX2018B501）; “225” Project to Train High?level Health Personnel in Hunan Province

摘要/Abstract

摘要： 痤疮是毛囊皮脂腺单位的慢性炎症性疾病。皮脂含量增加是痤疮发生的前提，皮脂成分改变促进痤疮炎症反应。皮脂稳态失衡是痤疮发生的关键因素之一。由于皮脂成分复杂、结构多样，使用单一的实验方法很难对皮脂中的所有脂质化合物进行分析。脂质组学可对数百种不同性质和生物活性的脂质进行定性和定量分析，为深入了解皮脂在痤疮发病机制中的作用提供了可能。本文综述目前脂质组学在痤疮皮脂分析中的应用。

关键词: 寻常痤疮, 脂肪酸类, 非酯化, 角鲨烯, 神经酰胺类, 过氧化物酶体增殖物激活受体, 脂质组学, 皮脂稳态失衡

Abstract: Acne is a chronic inflammatory dermatosis of pilosebaceous units. Increased sebum content is the precondition of acne occurrence, and changes of sebum components promote inflammatory reactions in acne. Imbalance of sebum homeostasis is one of the key factors for acne occurrence. Due to the complex composition and diverse structure of sebum, it is difficult to analyze all lipid compounds in sebum by using a single experimental method. Lipidomics can be used to qualitatively and quantitatively analyze hundreds of lipids with different properties and biological activities, which provides a potential insight into the role of sebum in the pathogenesis of acne. This review summarizes application of lipidomics in the analysis of sebum in acne patients.

Key words: Acne vulgaris, Fatty acids, nonesterified, Squalene, Ceramides, Peroxisome proliferator-activated receptors, Lipidomics, Sebum homeostasis imbalance

魏露朱明芳鞠强. 脂质组学在痤疮皮脂分析中的应用[J]. 中华皮肤科杂志, 2020,53(10):853-856. doi:10.35541/cjd.20190535

Wei Lu, Zhu Mingfang, Ju Qiang. Application of lipidomics in the analysis of sebum in acne patients[J]. Chinese Journal of Dermatology, 2020, 53(10): 853-856.doi:10.35541/cjd.20190535

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脂质组学在痤疮皮脂分析中的应用

Application of lipidomics in the analysis of sebum in acne patients

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