中华皮肤科杂志 ›› 2021, Vol. 54 ›› Issue (7): 642-645.doi: 10.35541/cjd.20191018
• 综述 • 上一篇
应洁雅1,相文忠2,宋秀祖2
收稿日期:
2019-10-22
修回日期:
2020-07-28
发布日期:
2021-07-02
通讯作者:
相文忠
E-mail:xiangwenzhong@126.com
Ying Jieya1, Xiang Wenzhong2, Song Xiuzu2
Received:
2019-10-22
Revised:
2020-07-28
Published:
2021-07-02
Contact:
Xiang Wenzhong
E-mail:xiangwenzhong@126.com
摘要: 【摘要】 代谢综合征(MS)是一组以多种代谢性疾病合并出现为特点的临床症候群,是个体发展为2型糖尿病和心血管疾病的重要危险因素。其发病机制不明,可能涉及胰岛素抵抗、慢性炎症反应及氧化应激等。研究表明,MS与丘疹鳞屑性皮肤病、皮肤附属器疾病、皮炎湿疹类皮肤病、色素性疾病密切相关。本文综述MS与相关皮肤病的联系。
应洁雅 相文忠 宋秀祖. 代谢综合征与皮肤病[J]. 中华皮肤科杂志, 2021,54(7):642-645. doi:10.35541/cjd.20191018
Ying Jieya, Xiang Wenzhong, Song Xiuzu. Metabolic syndrome and skin diseases[J]. Chinese Journal of Dermatology, 2021, 54(7): 642-645.doi:10.35541/cjd.20191018
[1] | Li R, Li W, Lun Z, et al. Prevalence of metabolic syndrome in Mainland China: a meta⁃analysis of published studies[J]. BMC Public Health, 2016,16:296. doi: 10.1186/s12889⁃016⁃2870⁃y. |
[2] | Expert Panel on Detection, Evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III)[J]. JAMA, 2001,285(19):2486⁃2497. doi: 10.1001/jama.285.19.2486. |
[3] | 中华医学会糖尿病学分会代谢综合征研究协作组. 中华医学会糖尿病学分会关于代谢综合征的建议[J]. 中华糖尿病杂志, 2004,12(3):156⁃161. doi: 10.3321/j.issn:1006⁃6187.2004.03. 002. |
[4] | Alberti KG, Zimmet P, Shaw J. Metabolic syndrome⁃⁃a new world⁃wide definition. A consensus statement from the international diabetes federation[J]. Diabet Med, 2006,23(5):469⁃480. doi: 10.1111/j.1464⁃5491.2006.01858.x. |
[5] | Leroith D. Pathophysiology of the metabolic syndrome: implications for the cardiometabolic risks associated with type 2 diabetes[J]. Am J Med Sci, 2012,343(1):13⁃16. doi: 10.1097/MAJ.0b013e31823ea214. |
[6] | 叶丰卉, 晋红中. 脂肪组织原位炎症与代谢[J]. 中华皮肤科杂志, 2017,50(2):149⁃152. doi: 10.3760/cma.j.issn.0412⁃4030. 2017.02.031. |
[7] | 魏伊秋. 慢性炎症与胰岛素抵抗机制关系的研究进展[J]. 临床与病理杂志, 2019,3(39):196⁃201. doi: 10.3978/j.issn.2095⁃6959.2019.03.030. |
[8] | Vona R, Gambardella L, Cittadini C, et al. Biomarkers of oxidative stress in metabolic syndrome and associated diseases[J]. Oxid Med Cell Longev, 2019,2019(2):1⁃19. doi: 10.1155/2019/8267234. |
[9] | Tangvarasittichai S. Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus[J]. World J Diabetes 2015,6(3):456⁃480. doi: 10.4239/wjd.v6.i3.456. |
[10] | Paschoal RS, Silva DA, Cardili RN, et al. Metabolic syndrome, C⁃reactive protein and cardiovascular risk in psoriasis patients: a cross⁃sectional study[J]. An Bras Dermatol, 2018,93(2):222⁃228. doi: 10.1590/abd1806⁃4841.20186397. |
[11] | Snekvik I, Nilsen TIL, Romundstad PR, et al. Metabolic syndrome and risk of incident psoriasis: prospective data from the HUNT Study, Norway[J]. Br J Dermatol, 2019,180(1):94⁃99. doi: 10.1111/bjd.16885. |
[12] | Kim HN, Han K, Park YG, et al. Metabolic syndrome is associated with an increased risk of psoriasis: a nationwide population⁃based study[J]. Metab Clin Exp, 2019,99:19⁃24. doi: 10.1016/j.metabol.2019.07.001. |
[13] | Al Mutairi N, Alrqobah D, Haji Hussain N. Prevalence of metabolic syndrome in children with moderate to severe psoriasis treated with TNF inhibitors in comparison to conventional agents[J]. Dermatol Ther, 2018,31(1):e12566. doi: 10.1111/dth.12566. |
[14] | Xu X, Lin L, Chen P, et al. Treatment with liraglutide, a glucagon⁃like peptide⁃1 analogue, improves effectively the skin lesions of psoriasis patients with type 2 diabetes: a prospective cohort study[J]. Diabetes Res Clin Pract, 2019,150:167⁃173. doi: 10. 1016/j.diabres.2019.03.002. |
[15] | 陈文娟, 彭琛, 丁杨峰, 等. 银屑病共病的研究进展[J]. 中华皮肤科杂志, 2020,53(2):147⁃151. doi: 10.35541/cjd.20190093. |
[16] | Mushtaq S, Dogra D, Dogra N, et al. Cardiovascular and metabolic risk assessment in patients with lichen planus: a tertiary care hospital⁃based study from northern India[J]. Indian Dermatol Online J, 2020,11(2):158⁃166. doi: 10.4103/idoj.IDOJ_ 228_19. |
[17] | Okpala IC, Akinboro AO, Ezejoifor IO, et al. Metabolic syndrome and dyslipidemia among Nigerians with lichen planus: a cross⁃sectional study[J]. Indian J Dermatol, 2019,64(4):303⁃310. doi:10.4103/ijd.IJD_111_18. |
[18] | Kumar SA, Krishnam Raju PV, Gopal KVT, et al. Comorbidities in lichen planus: a case⁃control study in Indian patients[J]. Indian Dermatol Online J, 2019,10(1):34⁃37. doi: 10.4103/idoj.IDOJ_48_18. |
[19] | Aktaş Karabay E, Saltık ZA, Unay Demirel Ö. Evaluation of serum FoxO1, mTORC1, IGF⁃1, IGFBP⁃3 levels and metabolic syndrome components in patients with acne vulgaris: a prospective case⁃control study[J]. Dermatol Ther, 2020:e13887. doi: 10.1111/dth.13887. |
[20] | Nagpal M, De D, Handa S, et al. Insulin resistance and metabolic syndrome in young men with acne[J]. JAMA Demtol, 2016,152(4):399⁃404. doi: 10.1001/jamadermatol.2015.4499. |
[21] | Franik G, Bizoń A, Włoch S, et al. Hormonal and metabolic aspects of acne vulgaris in women with polycystic ovary syndrome[J]. Eur Rev Med Pharmacol Sci, 2018,22(14):4411⁃4418. doi: 10.26355/eurrev_201807_15491. |
[22] | Akin Belli A, Ozbas Gok S, Akbaba G, et al. The relationship between rosacea and insulin resistance and metabolic syndrome[J]. Eur J Dermatol, 2016,26(3):260⁃264. doi: 10.1684/ejd.2016. 2748. |
[23] | Rainer BM, Fischer AH, Luz Felipe da Silva D, et al. Rosacea is associated with chronic systemic diseases in a skin severity⁃dependent manner: results of a case⁃control study[J]. J Am Acad Dermatol, 2015,73(4):604⁃608. doi: 10.1016/j.jaad.2015. 07.009. |
[24] | Phan K, Charlton O, Smith SD. Hidradenitis suppurativa and metabolic syndrome ⁃ systematic review and adjusted meta⁃analysis[J]. Int J Dermatol, 2019,58(10):1112⁃1117. doi:10. 1111/ijd.14500. |
[25] | Golbari NM, Porter ML, Kimball AB. Antiandrogen therapy with spironolactone for the treatment of hidradenitis suppurativa[J]. J Am Acad Dermatol, 2019,80(1):114⁃119. doi: 10.1016/j.jaad. 2018.06.063. |
[26] | González⁃López MA, Vilanova I, Ocejo⁃Viñals G, et al. Circulating levels of adiponectin, leptin, resistin and visfatin in non⁃diabetics patients with hidradenitis suppurativa[J]. Arch Dermatol Res, 2019,312(8):595⁃600. doi: 10.1007/s00403⁃019⁃02018⁃4. |
[27] | Swaroop MR, Kumar BM, Sathyanarayana BD, et al. The association of metabolic syndrome and insulin resistance in early⁃onset androgenetic alopecia in males: a case⁃control study[J]. Indian J Dermatol, 2019,64(1):23⁃27. doi: 10.4103/ijd.IJD_724_16. |
[28] | El Sayed MH, Abdallah MA, Aly DG, et al. Association of metabolic syndrome with female pattern hair loss in women: a case⁃control study[J]. Int J Dermatol, 2016,55(10):1131⁃1137. doi: 10.1111/ijd.13303. |
[29] | Misitzis A, Cunha PR, Kroumpouzos G. Skin disease related to metabolic syndrome in women[J]. Int J Womens Dermatol, 2019,5(4):205⁃212. doi: 10.1016/j.ijwd.2019.06.030. |
[30] | Lee S, Lee H, Lee CH, et al. Comorbidities in alopecia areata: a systematic review and meta⁃analysis[J]. J Am Acad Dermatol, 2019,80(2):466⁃477.e16. doi: 10.1016/j.jaad.2018.07.013. |
[31] | Shahidi⁃Dadras M, Bahraini N, Rajabi F, et al. Patients with alopecia areata show signs of insulin resistance[J]. Arch Dermatol Res, 2019,311(7):529⁃533. doi: 10.1007/s00403⁃019⁃01929⁃6. |
[32] | Schiffrin EL. Immune mechanisms in hypertension and vascular injury[J]. Clin Sci, 2014,126(4):267⁃274. doi: 10.1042/CS2013 0407. |
[33] | Shalom G, Dreiher J, Kridin K, et al. Atopic dermatitis and the metabolic syndrome: a cross⁃sectional study of 116 816 patients[J]. J Eur Acad Dermatol Venereol, 2019,33(9):1762⁃1767. doi: 10.1111/jdv.15642. |
[34] | Shalom G, Magen E, Babaev M, et al. Chronic urticaria and the metabolic syndrome: a cross⁃sectional community⁃based study of 11 261 patients[J]. J Eur Acad Dermatol Venereol, 2018,32(2):276⁃281. doi: 10.1111/jdv.14548. |
[35] | Vena GA, Cassano N. The link between chronic spontaneous urticaria and metabolic syndrome[J]. Eur Ann Allergy Clin Immunol, 2017,49(5):208⁃212. doi: 10.23822/EurAnnACI.1764⁃1489.12. |
[36] | Sharma YK, Bansal P, Menon S, et al. Metabolic syndrome in vitiligo patients among a semi⁃urban Maharashtrian population: a case control study[J]. Diabetes Metab Syndr, 2017,11:S77⁃S80. doi: 10.1016/j.dsx.2016.12.009. |
[37] | Tanacan E, Atakan N. Higher incidence of metabolic syndrome components in vitiligo patients: a prospective cross⁃sectional study[J]. An Bras Dermatol, 2020,95(2):165⁃172. doi: 10.1016/j.abd.2019.07.006. |
[38] | Seremet S, Gurel MS. Miscellaneous skin disease and the metabolic syndrome[J]. Clin Dermatol, 2018,36(1):94⁃100. doi: 10.1016/j.clindermatol.2017.09.016. |
[39] | Singh SK, Agrawal NK, Vishwakarma AK. Association of acanthosis nigricans and acrochordon with insulin resistance: a cross⁃sectional hospital⁃based study from north India[J]. Indian J Dermatol, 2020,65(2):112⁃117. doi: 10.4103/ijd.IJD_646_18. |
[40] | Hallajzadeh J, Khoramdad M, Izadi N, et al. The association between metabolic syndrome and its components with systemic lupus erythematosus: a comprehensive systematic review and meta⁃analysis of observational studies[J]. Lupus, 2018,27(6):899⁃912. doi: 10.1177/0961203317751047. |
[41] | Lesniewska A, Kalińska⁃Bienias A, Kowalewski C, et al. Development of bullous pemphigoid in a patient with psoriasis and metabolic syndrome[J]. Cutis, 2016,98(3):E19. |
[42] | Petermann Smits DR, Wilde B, Kianersi Adegani M, et al. Metabolic syndrome in ANCA⁃associated vasculitis[J]. Rheumatology (Oxford), 2013,52(1):197⁃203. doi: 10.1093/rheumatology/kes345. |
[43] | Nagase T, Akase T, Sanada H, et al. Aging⁃like skin changes in metabolic syndrome model mice are mediated by mineralocorticoid receptor signaling[J]. Aging Cell, 2013,12(1):50⁃57. doi: 10.1111/acel.12017. |
[44] | Nagel G, Bjørge T, Stocks T, et al. Metabolic risk factors and skin cancer in the metabolic syndrome and cancer project (Me⁃Can)[J]. Br J Dermatol, 2012,167(1):59⁃67. doi: 10.1111/j. 1365⁃2133.2012.10974.x. |
[1] | 吴淑辉 朱明芳 张曦 杨逸璇 张娟娟. 牛奶对金黄地鼠皮脂腺斑及IGF-1/SREBP-1/ACC-1信号通路的影响[J]. 中华皮肤科杂志, 2022, 55(3): 238-242. |
[2] | 王玥 严煜林. 寻常型银屑病患者171例阿维A治疗相关不良反应及停药原因分析[J]. 中华皮肤科杂志, 2022, 55(3): 242-245. |
[3] | 李妍 李明 徐薇 李邻峰. 【开放获取】丙酸氟替卡松乳膏单独或联合卡泊三醇软膏治疗轻中度斑块状银屑病的随机自身对照研究[J]. 中华皮肤科杂志, 2022, 55(3): 260-263. |
[4] | 王召阳 陈安薇 向欣 罗晓燕 徐子刚 王华 马琳. 基于两家儿童医院信息系统的儿童银屑病现状调查[J]. 中华皮肤科杂志, 2022, 55(3): 246-250. |
[5] | 王晓雯 李若瑜. 白细胞介素17相关生物制剂治疗银屑病过程中浅部真菌感染的发生及应对策略[J]. 中华皮肤科杂志, 2022, 55(3): 272-275. |
[6] | 付超 吴姣娜 郎文超 高菲 牛贵业 边培雯 高敏虹 司晓青 辛琳琳. 皮肤镜检查在评估白癜风疾病活动性中的作用[J]. 中华皮肤科杂志, 2022, 55(3): 268-271. |
[7] | 《脓疱型银屑病诊疗中国专家共识(版)》编写委员会专家组. 脓疱型银屑病诊疗中国专家共识(2022版)[J]. 中华皮肤科杂志, 2022, 55(3): 187-195. |
[8] | 艾尼瓦尔·塔力甫 熊成 热甫哈提·赛买提 玉苏甫·买提努尔 吐尔逊·吾甫尔 阿肯木江·艾尔肯 居来提·阿不都瓦衣提 买买提艾力·卡的. 生物信息学鉴定和分析白癜风差异表达基因[J]. 中华皮肤科杂志, 2022, 0(2): 20200391-e20200391. |
[9] | 张婷婷 朱凤仪 杨梅 张平 夏萍 周小勇. 司库奇尤单抗治疗红皮病型银屑病7例的临床疗效及安全性观察[J]. 中华皮肤科杂志, 2022, 0(2): 20210644-e20210644. |
[10] | 欧敏, 颜韵灵, 郑宝庆, 王晓华. 银屑病与肥胖相关性的研究进展[J]. 中华皮肤科杂志, 2022, 55(2): 181-184. |
[11] | 张国毅, 龚向东, 朱伯堃, 柳传霞, 景玲华, 徐金玉. 2019年中国医学科学院皮肤病医院门诊病种分析[J]. 中华皮肤科杂志, 2022, 55(2): 150-152. |
[12] | 陆佳维, 鲁严. 肿瘤坏死因子α抑制剂及其他生物制剂相关矛盾性银屑病的临床进展[J]. 中华皮肤科杂志, 2022, 0(1): 20210420-e20210420. |
[13] | 陈怡, 宋秀祖. 瞬时受体电位通道在黑素细胞中的作用及相关疾病研究[J]. 中华皮肤科杂志, 2022, 0(1): 20200958-e20200958. |
[14] | 栾超 胡煜 陈崑 张家安 顾恒 张荣林 张小华 田盼盼 朱艳 庄晨 黄丹 鞠梅. 308 nm SQ LED光与308 nm准分子光治疗面部白癜风的疗效及安全性回顾性研究[J]. 中华皮肤科杂志, 2022, 55(1): 16-19. |
[15] | 中华医学会皮肤性病学分会 中国医师协会皮肤科医师分会. 自身免疫性表皮下大疱病诊疗共识(2022)[J]. 中华皮肤科杂志, 2022, 55(1): 1-11. |
|