中华皮肤科杂志 ›› 2024, e20220865.doi: 10.35541/cjd.20220865
陈星宇 姚煦
收稿日期:2022-12-05
修回日期:2023-12-22
发布日期:2024-02-06
通讯作者:
姚煦
E-mail:dryao_xu@126.com
作者简介:2023年12月28日校样
基金资助:Chen Xingyu, Yao Xu
Received:2022-12-05
Revised:2023-12-22
Published:2024-02-06
Contact:
Yao Xu
E-mail:dryao_xu@126.com
Supported by:摘要： 【摘要】 中性粒细胞是机体免疫防御系统中的重要细胞之一，既往被视为固有免疫的参与者，随着研究的不断深入，发现其具有调节特性，可通过传达激活、抑制和迁移信号，引导并调节局部免疫反应。近年来多项炎症性皮肤病相关研究也揭示了中性粒细胞在皮肤病发生发展中的重要作用。在银屑病中，中性粒细胞可间接通过白细胞介素17/白细胞介素23轴或抗菌肽增强炎症反应；在系统性红斑狼疮中，中性粒细胞能调节干扰素信号转导和自身抗体的形成；在特应性皮炎中，中性粒细胞影响细菌定植和瘙痒等。因此，中性粒细胞在炎症性皮肤病中的主要作用机制包括中性粒细胞参与免疫细胞交流网络调控疾病发展和中性粒细胞的炎性死亡方式NETosis在疾病免疫中产生多重影响。本文综述中性粒细胞在部分炎症性皮肤病发生发展中的作用研究进展。
陈星宇 姚煦. 中性粒细胞在炎症性皮肤病中的研究进展[J]. 中华皮肤科杂志, 2024,e20220865. doi:10.35541/cjd.20220865
Chen Xingyu, Yao Xu. Role of neutrophils in inflammatory dermatoses[J]. Chinese Journal of Dermatology,2024,e20220865. doi:10.35541/cjd.20220865
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