中性粒细胞在炎症性皮肤病中的研究进展

doi:10.35541/cjd.20220865

中华皮肤科杂志 ›› 2024, e20220865.doi: 10.35541/cjd.20220865

中性粒细胞在炎症性皮肤病中的研究进展

陈星宇姚煦

中国医学科学院北京协和医学院皮肤病医院过敏与风湿免疫科，南京 210042

收稿日期:2022-12-05 修回日期:2023-12-22 发布日期:2024-02-06
通讯作者: 姚煦 E-mail:dryao_xu@126.com
基金资助:
国家自然科学基金（82073446、82103735）；江苏省社会发展重大项目（BE2020632）；南京市国家级临床医学中心培育计划项目（2019060001）；中国医学科学院医学与健康科技创新工程项目（2021-I2M-1-059）

Role of neutrophils in inflammatory dermatoses

Chen Xingyu, Yao Xu

Department of Allergy and Rheumatology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China

Received:2022-12-05 Revised:2023-12-22 Published:2024-02-06
Contact: Yao Xu E-mail:dryao_xu@126.com
Supported by:
National Natural Science Foundation of China （82073446, 82103735）; Key Project of Social Development in Jiangsu Province （BE2020632）; Nanjing Incubation Program for National Clinical Research Center （2019060001）; CAMS Innovation Fund for Medical Sciences （2021-I2M-1-059）

摘要/Abstract

摘要： 【摘要】中性粒细胞是机体免疫防御系统中的重要细胞之一，既往被视为固有免疫的参与者，随着研究的不断深入，发现其具有调节特性，可通过传达激活、抑制和迁移信号，引导并调节局部免疫反应。近年来多项炎症性皮肤病相关研究也揭示了中性粒细胞在皮肤病发生发展中的重要作用。在银屑病中，中性粒细胞可间接通过白细胞介素17/白细胞介素23轴或抗菌肽增强炎症反应；在系统性红斑狼疮中，中性粒细胞能调节干扰素信号转导和自身抗体的形成；在特应性皮炎中，中性粒细胞影响细菌定植和瘙痒等。因此，中性粒细胞在炎症性皮肤病中的主要作用机制包括中性粒细胞参与免疫细胞交流网络调控疾病发展和中性粒细胞的炎性死亡方式NETosis在疾病免疫中产生多重影响。本文综述中性粒细胞在部分炎症性皮肤病发生发展中的作用研究进展。

关键词: 中性白细胞, 银屑病, 红斑狼疮, 系统性, 皮炎, 特应性, 皮炎, 接触性, 嗜中性粒细胞皮肤病

Abstract: 【Abstract】 Neutrophils are important in the immune defense system. Historically, neutrophils have been regarded as participants in innate immunity. Now, with the deepening of research, it has been found that neutrophils have regulatory properties, which can guide and regulate the local immune response by transmitting activation, inhibition and migration signals. In recent years, several studies related to inflammatory dermatoses have revealed the important roles of neutrophils in the occurrence and development of skin diseases. In psoriasis, neutrophils can indirectly enhance inflammatory response through interleukin-17/interleukin-23 axis or antimicrobial peptides; in systemic lupus erythematosus, neutrophils can regulate the interferon signal transduction and the formation of autoantibodies; in atopic dermatitis, neutrophils can affect bacterial colonization and itching, etc. In a word, the main mechanisms of action of neutrophils in inflammatory dermatoses include the involvement of neutrophils in immune cell communication networks to regulate disease development and the multiple roles of NETosis as a mode of neutrophil inflammatory death in disease immunity. This review summarizes the research progress on the roles of neutrophils in the occurrence and development of some inflammatory dermatoses.

Key words: Neutrophils, Psoriasis, Lupus erythematosus, systemic, Dermatitis, atopic, Dermatitis, contact, Neutrophilic dermatoses

陈星宇姚煦. 中性粒细胞在炎症性皮肤病中的研究进展[J]. 中华皮肤科杂志, 2024,e20220865. doi:10.35541/cjd.20220865

Chen Xingyu, Yao Xu. Role of neutrophils in inflammatory dermatoses[J]. Chinese Journal of Dermatology,2024,e20220865. doi:10.35541/cjd.20220865

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中性粒细胞在炎症性皮肤病中的研究进展

Role of neutrophils in inflammatory dermatoses

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