中华皮肤科杂志 ›› 2025, Vol. 58 ›› Issue (4): 374-377.doi: 10.35541/cjd.20240520

• 综述 • 上一篇    下一篇

细胞治疗在系统性红斑狼疮中的应用

吕铭悦,满孝勇   

  1. 浙江大学医学院附属第二医院皮肤科,杭州  310009
  • 收稿日期:2024-09-30 修回日期:2025-02-06 发布日期:2025-04-03
  • 通讯作者: 满孝勇 E-mail:manxy@zju.edu.cn

Application of cell therapy in systemic lupus erythematosus

Lyu Mingyue, Man Xiaoyong   

  1. Department of Dermatology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
  • Received:2024-09-30 Revised:2025-02-06 Published:2025-04-03
  • Contact: Man Xiaoyong E-mail:manxy@zju.edu.cn

摘要: 【摘要】 系统性红斑狼疮是一种累及多器官、多系统的慢性自身免疫性疾病,目前的治疗方案仅能实现临床缓解。近年来,细胞治疗在自身免疫病领域取得了突破性进展,尤其是嵌合抗原受体技术展现出了治愈该类疾病的潜力。本文综述多种细胞疗法在系统性红斑狼疮中的应用与前景,包括造血干细胞移植、间充质干细胞、嵌合抗原受体-T细胞、自然杀伤细胞以及调节性T细胞等疗法,以期为未来细胞治疗的技术优化与临床推广提供参考。

关键词: 红斑狼疮, 系统性, 细胞治疗, 造血干细胞移植, 间充质干细胞, 嵌合抗原受体-T细胞, 自然杀伤细胞, 调节性T细胞

Abstract: 【Abstract】 Systemic lupus erythematosus is a chronic autoimmune disease that affects multiple organs and systems, and current treatment strategies can only result in clinical remission. In recent years, cell therapies have shown promising advancements in the treatment of autoimmune diseases, particularly chimeric antigen receptor technology has demonstrated potential as a transformative therapy for these diseases. This review summarizes the application and prospects of various cell therapies in systemic lupus erythematosus, including hematopoietic stem cell transplantation, mesenchymal stem cell therapy, chimeric antigen receptor-T cell therapy, natural killer cell therapy, and regulatory T cell therapy, aiming to provide insights for optimization and clinical implementation of cell therapies.

Key words: Lupus erythematosus, systemic, Cell therapy, Hematopoietic stem cell transplantation, Mesenchymal stem cells, Chimeric antigen receptor-T cells, Natural killer cells, Regulatory T cells

引用本文

吕铭悦 满孝勇. 细胞治疗在系统性红斑狼疮中的应用[J]. 中华皮肤科杂志, 2025,58(4):374-377. doi:10.35541/cjd.20240520

Lyu Mingyue, Man Xiaoyong. Application of cell therapy in systemic lupus erythematosus[J]. Chinese Journal of Dermatology, 2025, 58(4): 374-377.doi:10.35541/cjd.20240520