多环芳烃在炎症性皮肤病发生发展中的作用研究进展

doi:10.35541/cjd.20220271

中华皮肤科杂志 ›› 2023, e20220271.doi: 10.35541/cjd.20220271

多环芳烃在炎症性皮肤病发生发展中的作用研究进展

林子沅^1，2，3 庞天怡⁴ 武静文⁵ 靳慧^1，2，3

¹中国医学科学院北京协和医学院皮肤病医院，南京 210042；²中国医学科学院免疫性皮肤病基础与转化研究重点实验室，南京 210042；³中南大学湘雅二医院皮肤科医学表观基因组学湖南省重点实验室，长沙 410011；⁴中南大学湘雅医院皮肤科，长沙 410011；⁵上海交通大学医学院附属瑞金医院皮肤科，上海 200025

收稿日期:2022-04-19 修回日期:2022-10-08 发布日期:2023-07-12
通讯作者: 靳慧 E-mail:jh2020@csu.edu.cn, jin1010hui@126.com
基金资助:
国家自然科学基金（81874253）；湖南省自然科学基金（2021JJ40837）；湖南省科技创新人才计划优秀博士后创新人才项目（2020RC2014）；中国博士后科学基金第15批特别资助（站中）项目（2022T150742）

Role of polycyclic aromatic hydrocarbons in the occurrence and development of inflammatory skin diseases

Lin Ziyuan^1,2,3, Pang Tianyi⁴, Wu Jingwen⁵, Jin Hui^1,2,3

Received:2022-04-19 Revised:2022-10-08 Published:2023-07-12
Contact: Jin Hui E-mail:jh2020@csu.edu.cn, jin1010hui@126.com
Supported by:
National Natural Science Foundation of China （81874253）; Natural Science Foundation of Hunan Province of China （2021JJ40837）; Excellent Postdoctoral Innovative Talents of Hunan Province in 2020 （2020RC2014）; The 15th Medium-term Special Grant of Postdoctoral Science Foundation of China （2022T150742）

摘要/Abstract

摘要： 【摘要】多环芳烃（PAH）是含两个以上苯环的化合物，广泛存在于环境之中，可通过各种途径影响人体健康。以往PAH对健康影响研究多集中在其致癌性、致畸性以及对肺部疾病、心血管疾病等的影响，近年来PAH对炎症性皮肤病（尤其是银屑病、特应性皮炎和红斑狼疮）的影响日益受到重视。本文综述PAH对炎症性皮肤病的研究进展。

关键词: 多环碳氢化合物, 芳香族, 烟雾, 颗粒物, 银屑病, 皮炎, 特应性, 红斑狼疮, 皮肤, 红斑狼疮, 系统性, 炎症性皮肤病

Abstract: 【Abstract】 Polycyclic aromatic hydrocarbons （PAHs） are compounds with more than two benzene rings, widely exist in the environment, and can affect human health in various ways. Previous studies on the health effects of PAHs mainly focused on their carcinogenicity, teratogenicity, and effects on pulmonary diseases, cardiovascular diseases, etc. In recent years, increasing attention has been paid to the negative influence of PAHs to inflammatory skin diseases （especially psoriasis, atopic dermatitis, and lupus erythematosus）. This review summarizes recent research advances in the role of PAHs in the occurrence and development of inflammatory skin diseases.

Key words: Polycyclic hydrocarbons, aromatic, Smog, Particulate matter, Psoriasis, Dermatitis, atopic, Lupus erythematosus, cutaneous, Lupus erythematosus, systemic, Inflammatory skin disease

林子沅庞天怡武静文靳慧. 多环芳烃在炎症性皮肤病发生发展中的作用研究进展[J]. 中华皮肤科杂志, 2023,e20220271. doi:10.35541/cjd.20220271

Lin Ziyuan, Pang Tianyi, Wu Jingwen, Jin Hui, . Role of polycyclic aromatic hydrocarbons in the occurrence and development of inflammatory skin diseases[J]. Chinese Journal of Dermatology,2023,e20220271. doi:10.35541/cjd.20220271

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多环芳烃在炎症性皮肤病发生发展中的作用研究进展

Role of polycyclic aromatic hydrocarbons in the occurrence and development of inflammatory skin diseases

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