中华皮肤科杂志 ›› 2023, e20230193.doi: 10.35541/cjd.20230193

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记忆性T细胞在慢性自身免疫性皮肤病中的研究进展

胡颖,焦晴晴   

  1. 苏州大学附属第一医院皮肤科,苏州  215006
  • 收稿日期:2023-04-07 修回日期:2023-06-12 发布日期:2023-09-04
  • 通讯作者: 焦晴晴 E-mail:qingqingjiao@suda.edu.cn
  • 基金资助:
    国家自然科学基金(82073434)

Memory T cells in chronic autoimmune skin diseases

Hu Ying, Jiao Qingqing   

  1. Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China 
  • Received:2023-04-07 Revised:2023-06-12 Published:2023-09-04
  • Contact: Jiao Qingqing E-mail:qingqingjiao@suda.edu.cn
  • Supported by:
    National Natural Science Foundation of China(82073434)

摘要: 【摘要】 慢性自身免疫性皮肤病是由于机体针对自身抗原物质产生免疫应答,从而引起炎症反应的一大类皮肤病。自身反应性记忆性T细胞能识别特异性自身抗原,能够长期刺激免疫反应从而维持皮肤的慢性炎症,引起复发。靶向疗法有望成为控制慢性自身免疫性皮肤病复发的有效手段。本文综述记忆性T细胞在慢性自身免疫性皮肤病的研究进展。

关键词: T淋巴细胞, 白癜风, 银屑病, 红斑狼疮, 皮肤, 记忆性T细胞, 免疫治疗

Abstract: 【Abstract】 Chronic autoimmune skin diseases are a large group of skin diseases in which the inflammatory response is caused by the body′s immune response to self-antigenic substances. Autoreactive memory T cells can recognize specific autoantigens, and are able to chronically stimulate immune responses, thereby maintaining chronic inflammation of the skin and causing relapse. Targeted therapies hold promise as an effective means of controlling the relapse of chronic autoimmune skin diseases. This review summarizes research advances in the role of memory T cells in chronic autoimmune skin diseases.

Key words: T-lymphocytes, Vitiligo, Psoriasis, Lupus erythematosus, cutaneous, Memory T cells, Immunotherapy

引用本文

胡颖 焦晴晴. 记忆性T细胞在慢性自身免疫性皮肤病中的研究进展[J]. 中华皮肤科杂志, 2023,e20230193. doi:10.35541/cjd.20230193

Hu Ying, Jiao Qingqing. Memory T cells in chronic autoimmune skin diseases[J]. Chinese Journal of Dermatology,2023,e20230193. doi:10.35541/cjd.20230193