中华皮肤科杂志 ›› 2025, e20240647.doi: 10.35541/cjd.20240647

• 研究报道 • 上一篇    

关节病型银屑病患者血清中成纤维细胞生长因子23的表达及其临床意义

袁瑾1    曾晓丽2    林粼3    吴汶霖4    黄悦1    周昆丽1    蔡良奇1   

  1. 1厦门大学附属第一医院皮肤科，厦门  361002；2厦门大学附属第一医院风湿免疫科，厦门  361002；3厦门大学附属第一医院转化医学研究中心，厦门  361002；4广州医科大学附属妇女儿童医疗中心神经内科，广州  510000
  • 收稿日期:2024-11-27 修回日期:2025-09-06 发布日期:2025-11-04
  • 通讯作者: 蔡良奇 E-mail:clq196806@126.com

Expression and clinical significance of serum fibroblast growth factor-23 in patients with psoriatic arthritis

Yuan Jin1, Zeng Xiaoli2, Lin Lin3, Wu Wenlin4, Huang Yue1, Zhou Kunli1, Cai Liangqi1   

  1. 1Department of Dermatology, the First Affiliated Hospital of Xiamen University, Xiamen 361002, China; 2Department of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, Xiamen 361002, China; 3Translational Medicine Research Center, the First Affiliated Hospital of Xiamen University, Xiamen 361002, China; 4Department of Neurology, Guangzhou Women and Children′s Medical Center, Guangzhou Medical University, Guangzhou 510000, China
  • Received:2024-11-27 Revised:2025-09-06 Published:2025-11-04
  • Contact: Cai Liangqi E-mail:clq196806@126.com

PDF

0

PDF (Mobile)

0

摘要： 【摘要】 目的 分析关节病型银屑病（PsA）患者血清成纤维细胞生长因子（FGF）23的表达水平及其与炎性标志物和疾病状态的相关性。方法 回顾性收集2020年1月至12月就诊于厦门大学附属第一医院的25例PsA患者和25例健康对照，检测其血清FGF23及25-羟维生素D［25（OH）-VitD］水平，PsA患者同时检测C反应蛋白（CRP）、红细胞沉降率（ESR），并采用PsA疾病活动度评分（DAPSA）评估疾病状态。比较高CRP组（> 3 mg/L）和CRP正常组（≤ 3 mg/L），高ESR组（> 15 mm/1 h）和ESR正常组（≤ 15 mm/1 h），以及中高疾病活动度组（DAPSA＞14分）和低疾病活动度组（DAPSA≤ 14分）PsA患者血清FGF23及25（OH）-VitD水平的差异，并探讨FGF23与CRP、ESR、DAPSA、25（OH）-VitD之间的相关性。统计分析主要采用独立样本t检验和Spearman相关分析。结果 PsA患者血清FGF23水平（224.30 pg/ml ± 25.83 pg/ml）显著高于健康对照（123.80 pg/ml ± 11.76 pg/ml；t = 3.54，P < 0.05），而血清25（OH）-VitD水平两组间差异无统计学意义（P > 0.05）。PsA患者中，高CRP组血清FGF23水平高于正常CRP组，高ESR组血清FGF23水平高于正常ESR组，中高疾病活动度组血清FGF23高于低疾病活动度组，差异均有统计学意义（均P < 0.05）；而高CRP组和正常CRP组，高ESR组和正常ESR组及中高疾病活动度组和低疾病活动度组患者间25（OH）-VitD差异无统计学意义（均P > 0.05）。在PsA患者中，血清FGF23水平与CRP、ESR和DAPSA均呈正相关（均P < 0.05），但与血清25（OH）-VitD的相关性无统计学意义（P = 0.914）。结论 PsA患者血清FGF23水平高于健康人群，且与CRP、ESR、DAPSA评分呈正相关。

关键词: 银屑病关节炎, 成纤维细胞生长因子23, 骨化二醇, 血沉, C反应蛋白质, 疾病活动度

Abstract: 【Abstract】 Objective To detect serum levels of fibroblast growth factor （FGF）-23 in patients with psoriatic arthritis （PsA）, and to explore its correlation with inflammatory markers and disease severity. Methods Twenty-five PsA patients and 25 healthy controls were retrospectively enrolled from the First Affiliated Hospital of Xiamen University between January and December 2020. Serum levels of FGF23 and 25-hydroxyvitamin D （25［OH］VitD） were detected in all participants. In PsA patients, C-reactive protein （CRP） and erythrocyte sedimentation rate （ESR） were also measured, and disease activity was assessed using the disease activity index for psoriatic arthritis （DAPSA）. Differences in the serum levels of FGF23 and 25（OH）VitD were analyzed between high CRP （> 3 mg/L） and normal CRP （≤ 3 mg/L） subgroups, between high ESR （> 15 mm/1 h） and normal ESR （≤ 15 mm/1 h） subgroups, as well as between moderate-to-high disease activity （DAPSA > 14 points） and low disease activity （DAPSA ≤ 14 points） subgroups. Correlations of FGF23 with CRP, ESR, DAPSA, and 25（OH）VitD were analyzed. Statistical analyses were carried out by two-independent-sample t test and Spearman correlation analysis. Results Serum FGF23 levels were significantly higher in the PsA patients （224.30 ± 25.83 pg/ml） than in the healthy controls （123.80 ± 11.76 pg/ml, t = 3.54, P < 0.05）, while no significant difference was observed in serum 25（OH）VitD levels between the two groups （P > 0.05）. Among the PsA patients, the serum FGF23 levels were significantly higher in the high CRP group than in the normal CRP group, significantly higher in the high ESR group than in the normal ESR group, and significantly higher in the moderate-to-high disease activity group than in the low disease activity group （all P < 0.05）; however, there were no significant differences in the 25（OH）VitD levels between these subgroups （all P > 0.05）. In the PsA patients, the serum FGF23 levels showed positive correlations with the levels of CRP and ESR, as well as with DAPSA （all P < 0.05）, but no significant correlation with serum 25（OH）VitD levels （P = 0.914）. Conclusions Serum FGF23 levels were significantly higher in PsA patients than in healthy individuals, and were positively correlated with CRP, ESR, and DAPSA.

Key words: Arthritis, psoriatic, Fibroblast growth factor 23, Calcifediol, Blood sedimentation, C-Reactive protein, Disease activity

引用本文

袁瑾 曾晓丽 林粼 吴汶霖 黄悦 周昆丽 蔡良奇. 关节病型银屑病患者血清中成纤维细胞生长因子23的表达及其临床意义[J]. 中华皮肤科杂志, 2025,e20240647. doi:10.35541/cjd.20240647

Yuan Jin, Zeng Xiaoli, Lin Lin, Wu Wenlin, Huang Yue, Zhou Kunli, Cai Liangqi. Expression and clinical significance of serum fibroblast growth factor-23 in patients with psoriatic arthritis[J]. Chinese Journal of Dermatology,2025,e20240647. doi:10.35541/cjd.20240647