中华皮肤科杂志 ›› 2023, e20210809.doi: 10.35541/cjd.20210809

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白细胞介素23抑制剂治疗对银屑病共病的影响

李秀珍    徐秀莲   

  1. 中国医学科学院、北京协和医学院皮肤病医院病理科,南京  210042
  • 收稿日期:2021-11-05 修回日期:2022-04-13 发布日期:2023-05-31
  • 通讯作者: 徐秀莲 E-mail:xxlqil@sina.com

Effects of interleukin-23 inhibitors on psoriasis comorbidities

Li Xiuzhen, Xu Xiulian   

  1. Department of Pathology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2021-11-05 Revised:2022-04-13 Published:2023-05-31
  • Contact: Xu Xiulian E-mail:xxlqil@sina.com

摘要: 【摘要】 近年来,生物制剂在银屑病治疗中占据了重要地位。其中,白细胞介素23(IL-23)抑制剂显示出较高的有效性和安全性。同时,IL-23抑制剂治疗还对诸如银屑病关节炎、心血管疾病、代谢综合征、炎症性肠病等银屑病共病的发生、发展产生重要影响。本文从IL-23/IL-17通路参与各类银屑病共病的发病机制入手,结合相关临床试验、病例报道及国内外诊疗指南推荐,就IL-23抑制剂治疗对银屑病共病的影响进行综述,为伴不同共病的银屑病患者选择合适的治疗方案提供参考。

关键词: 银屑病, 共病现象, 关节炎, 牛皮癣, 炎性肠疾病, 心血管不良事件, 恶性肿瘤, 白细胞介素23抑制剂

Abstract: 【Abstract】 In recent years, biological agents have played an important role in the treatment of psoriasis, among which interleukin (IL)-23 inhibitors have shown favorable efficacy and safety. In addition, IL-23 inhibitors can influence the onset and development of psoriasis comorbidities, such as psoriatic arthritis, cardiovascular diseases, metabolic syndrome, and inflammatory bowel disease. This review first discusses the involvement of the IL-23/IL-17 pathway in the pathogenesis of various psoriasis comorbidities, and then summarizes the effects of IL-23 inhibitors on psoriasis comorbidities based on clinical trials, case reports, and Chinese and international guidelines, aiming to provide a reference for choosing appropriate treatments for psoriasis patients with different comorbidities.

Key words: Psoriasis, Comorbidity, Arthritis, psoriatic, Inflammatory bowel disease, Adverse cardiovascular events, Malignancy, Interleukin-23 inhibitors

引用本文

李秀珍 徐秀莲. 白细胞介素23抑制剂治疗对银屑病共病的影响[J]. 中华皮肤科杂志, 2023,e20210809. doi:10.35541/cjd.20210809

Li Xiuzhen, Xu Xiulian. Effects of interleukin-23 inhibitors on psoriasis comorbidities[J]. Chinese Journal of Dermatology,2023,e20210809. doi:10.35541/cjd.20210809