中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (11): 914-916.doi: 10.35541/cjd.20190742

• 研究报道 • 上一篇    下一篇

基于脂质组学的新生儿痤疮面部皮损脂质分析

杨明1    高莹1    周明月2    王贺聪2    贾焱2    何聪芬2    顾菲1    刘晓雁1   

  1. 1首都儿科研究所附属儿童医院皮肤科，北京  100020；2北京工商大学理学院  100048
  • 收稿日期:2019-07-12 修回日期:2020-03-03 发布日期:2020-11-03
  • 通讯作者: 杨明 E-mail:53055224@qq.com
  • 基金资助:
    国家自然科学基金 （81703106）；首都儿科研究所青年科研基金（QN-2018-06）

Lipidomics analysis of facial skin surface lipids of neonates with acne

Yang Ming1, Gao Ying1, Zhou Mingyue2, Wang Hecong2, Jia Yan2, He Congfen2, Gu Fei1, Liu Xiaoyan1   

  1. 1Department of Dermatology, Children′s Hospital, Capital Institute of Pediatrics, Beijing 100020, China; 2School of Science, Beijing Technology and Business University, Beijing 100048, China
  • Received:2019-07-12 Revised:2020-03-03 Published:2020-11-03
  • Contact: Yang Ming E-mail:53055224@qq.com
  • Supported by:
    National Natural Science Foundation of China （81703106）; Youth Research Fund of Capital Institute of Pediatrics （QN-2018-06）

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摘要： 【摘要】 目的 分析新生儿痤疮皮损和健康婴儿面部正常皮肤表面脂质（SSL）的差异。方法 2018年6 - 8月在首都儿科研究所附属儿童医院皮肤科收集36例新生儿痤疮（痤疮组）面部皮损及 36例健康婴儿（对照组）面部皮肤脂质标本。采用超高效液相色谱-四极杆飞行时间质谱联用技术得到脂质图谱,用多元数据分析方法得到脂质成分的具体信息。采用SPSS19.0软件进行独立样本t检验分析两组间差异。结果 与对照组相比，痤疮组患儿面部皮肤甘油脂类和孕烯醇酮脂类显著增加（均P < 0.001 ），但脂肪酸类、甘油磷脂类、鞘脂类、固醇脂类、糖脂类、多聚乙烯类显著下降（P < 0.01或0.05）。进一步分析显示，痤疮组脂质总量、甘油二酯、蜡酯 、角鲨烯平均相对含量均高于对照组（P < 0.001或0.05），但亚油酸平均相对含量低于对照组（P < 0.001）。结论 新生儿痤疮面部皮损脂质总量较健康婴儿明显增加，脂质成分也存在明显差异。

关键词: 寻常痤疮, 婴儿, 新生, 皮脂, 新生儿痤疮, 脂质组学

Abstract: 【Abstract】 Objective To analyze the difference in skin surface lipids （SSL） between facial skin lesions of neonates with acne and normal facial skin of healthy infants. Methods SSL samples were collected from facial skin lesions of 36 neonates with acne （acne group） and normal facial skin of 36 healthy infants （control group） at the Department of Dermatology, Children′s Hospital,Capital Institute of Pediatrics from June 2018 to August 2018. A lipid map was constructed by ultra-performance liquid chromatography-quadrupole-time of flight-mass spectrometry （UPLC-QTOF-MS）, and specific information about lipid components was obtained by multivariate data analysis. Independent-sample t test was performed with SPSS19.0 software for comparisons between 2 groups. Results Compared with the control group, the acne group showed significantly increased relative content of glycerolipids and prenol lipids on the facial skin surface （both P < 0.001）, but significantly decreased relative content of fatty acids, glycerophospholipids, sphingolipids, sterol lipids, saccharolipids and polyketides （P < 0.01 or < 0.05）.Further analysis showed that the average relative content of total lipids, diglycerides, wax esters and squalene was significantly higher in the acne group than in the control group （P < 0.001 or 0.05）, but the average relative content of linoleic acid was significantly lower in the acne group than in the control group （P < 0.001）. Conclusion Compared with the facial skin of healthy infants, the facial skin lesions of neonates with acne showed significantly increased total lipid content and different lipid components.

Key words: Acne vulgaris, Infant, newborn, Sebum, Neonatal acne, Lipidomics

引用本文

杨明 高莹 周明月 王贺聪 贾焱 何聪芬 顾菲 刘晓雁. 基于脂质组学的新生儿痤疮面部皮损脂质分析[J]. 中华皮肤科杂志, 2020,53(11):914-916. doi:10.35541/cjd.20190742

Yang Ming, Gao Ying, Zhou Mingyue, Wang Hecong, Jia Yan, He Congfen, Gu Fei, Liu Xiaoyan. Lipidomics analysis of facial skin surface lipids of neonates with acne[J]. Chinese Journal of Dermatology, 2020, 53(11): 914-916.doi:10.35541/cjd.20190742