中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (2): 169-172.doi: 10.35541/cjd.20200592

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JAK-STAT信号通路与玫瑰痤疮

王亚玲    谢红付    李吉    汪犇   

  1. 中南大学湘雅医院皮肤科  国家老年疾病临床医学研究中心(湘雅),长沙  410008
  • 收稿日期:2020-06-12 修回日期:2020-12-06 发布日期:2023-02-01
  • 通讯作者: 汪犇 E-mail:wangben0804@163.com
  • 基金资助:
    国家自然科学基金(81974480)

JAK-STAT signaling pathway and rosacea

Wang Yaling, Xie Hongfu, Li Ji, Wang Ben   

  1. Department of Dermatology, Xiangya Hospital, Central South University, National Clinical Research Center for Geriatric Disorders (Xiangya), Changsha 410008, China
  • Received:2020-06-12 Revised:2020-12-06 Published:2023-02-01
  • Contact: Wang Ben E-mail:wangben0804@163.com
  • Supported by:
    National Natural Science Foundation of China(81974480)

摘要: 【摘要】 研究表明玫瑰痤疮与炎症因子、神经脉管功能、微生态环境等多种因素有关。JAK-STAT信号通路涉及多种炎症细胞因子,在细胞增殖、分化、凋亡和血管生成及免疫调节等方面发挥重要作用。本文将概述JAK-STAT信号通路并探讨其在玫瑰痤疮中的潜在作用。

关键词: 红斑痤疮, 信号传导, 新生血管化, 病理性, JAK-STAT信号通路, 炎症因子, 抗菌肽

Abstract: 【Abstract】 Studies have shown that rosacea is related to inflammatory factors, neurovascular function, micro-ecological environment and other factors. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway involves a variety of inflammatory cytokines, and plays an important role in cell proliferation, differentiation, apoptosis, angiogenesis and immune regulation. This review summarizes the JAK-STAT signaling pathway and explores its potential role in rosacea.

Key words: Rosacea, Signal pathway, Neovascularization, pathologic, JAK-STAT signal pathway, Inflammatory factors, Antibacterial peptides

引用本文

王亚玲 谢红付 李吉 汪犇. JAK-STAT信号通路与玫瑰痤疮[J]. 中华皮肤科杂志, 2023,56(2):169-172. doi:10.35541/cjd.20200592

Wang Yaling, Xie Hongfu, Li Ji, Wang Ben. JAK-STAT signaling pathway and rosacea[J]. Chinese Journal of Dermatology, 2023, 56(2): 169-172.doi:10.35541/cjd.20200592