中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (3): 264-267.doi: 10.35541/cjd.20200155

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PI3K/Akt/mTOR信号通路在皮肤鳞状细胞癌中的研究进展

徐聪聪    陈浩   

  1. 中国医学科学院、北京协和医学院皮肤病医院病理科，南京  210042
  • 收稿日期:2020-02-22 修回日期:2020-07-23 发布日期:2022-03-03
  • 通讯作者: 陈浩 E-mail:ch76ch@163.com
  • 基金资助:
    江苏省六大人才高峰项目（WSN-030）；中国医学科学院医学与健康科技创新工程项目（CIFMS-2017-I2M-1-017）

The research progress of PI3K/Akt/mT0R signaling pathway in cutaneous squamous cell carcinoma

Xu Congcong, Chen Hao   

  1. Department of Pathology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2020-02-22 Revised:2020-07-23 Published:2022-03-03
  • Contact: Chen Hao E-mail:ch76ch@163.com
  • Supported by:
    Six Talent Peaks Project in Jiangsu Province （WSN-030）; CAMS Innovation Fund for Medical Sciences （CIFMS-2017-I2M-1-017）

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摘要： 【摘要】 皮肤鳞状细胞癌的发病机制复杂，晚期治疗手段缺乏。本文综述磷脂酰肌醇3-激酶/蛋白激酶B/哺乳类动物雷帕霉素靶蛋白（PI3K/Akt/mTOR）信号通路在皮肤鳞状细胞癌发病机制中的作用及针对其的治疗进展，为皮肤鳞状细胞癌的靶向治疗提供新思路。

关键词: 肿瘤, 鳞状细胞, 信号传导, 皮肤, PI3K/Akt/mTOR

Abstract: 【Abstract】 The pathogenesis of cutaneous squamous cell carcinoma （cSCC） is complicated, and treatment methods of advanced cSCC remain insufficient. This review summarizes the role of phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt）/mammalian target of rapamycin （mTOR） signaling pathway in the pathogenesis of cSCC, as well as progress in the treatment of cSCC targeting this pathway, and provides new ideas for targeted therapy of cSCC.

Key words: Neoplasms, squamous cell, Signal transduction, Skin, PI3K/Akt/mTOR

引用本文

徐聪聪 陈浩. PI3K/Akt/mTOR信号通路在皮肤鳞状细胞癌中的研究进展[J]. 中华皮肤科杂志, 2022,55(3):264-267. doi:10.35541/cjd.20200155

Xu Congcong, Chen Hao. The research progress of PI3K/Akt/mT0R signaling pathway in cutaneous squamous cell carcinoma[J]. Chinese Journal of Dermatology, 2022, 55(3): 264-267.doi:10.35541/cjd.20200155