中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (8): 711-717.doi: 10.35541/cjd.20230133
中国医师协会皮肤科医师分会
收稿日期:2023-03-09
修回日期:2023-05-24
发布日期:2023-08-07
通讯作者:
郝飞；高兴华
E-mail:haofei62@126.com; gaobarry@hotmail.com
China Dermatologist Association
Received:2023-03-09
Revised:2023-05-24
Published:2023-08-07
Contact:
Hao Fei; Gao Xinghua
E-mail:haofei62@126.com; gaobarry@hotmail.com
摘要： 【摘要】 应用保湿润肤类产品是保护或修护皮肤屏障、维护皮肤健康和防治皮肤病的重要手段。为规范及合理应用保湿润肤类产品，中国医师协会皮肤科医师分会组织国内有关专家，结合国内外研究现状，就保湿润肤类产品的功效、成分选择、应用指征、使用方法、不良反应及注意事项等深入讨论并达成此共识。
中国医师协会皮肤科医师分会. [开放获取] 保湿润肤类产品应用指导专家共识（2023版）[J]. 中华皮肤科杂志, 2023,56(8):711-717. doi:10.35541/cjd.20230133
China Dermatologist Association. Guidance on application of moisturizers and emollients: an expert consensus （2023）[J]. Chinese Journal of Dermatology, 2023, 56(8): 711-717.doi:10.35541/cjd.20230133
| ［1］ | Norlén L, Lundborg M, Wennberg C, et al. The skin′s barrier: a cryo⁃EM based overview of its architecture and stepwise formation［J］. J Invest Dermatol, 2022,142（2）:285⁃292. doi: 10. 1016/j.jid.2021.06.037. |
| ［2］ | Choi EH. Aging of the skin barrier［J］. Clin Dermatol, 2019,37（4）:336⁃345. doi: 10.1016/j.clindermatol.2019. 04.009. |
| ［3］ | Watkins P. Using emollients to restore and maintain skin integrity［J］. Nurs Stand, 2008,22（41）:51⁃58. doi: 10.7748/ns2008.06. 22.41.51.c6578. |
| ［4］ | Lodén M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders［J］. Am J Clin Dermatol, 2003,4（11）:771⁃788. doi: 10.2165/00128071⁃200304110⁃00005. |
| ［5］ | Anderson PC, Dinulos JG. Are the new moisturizers more effective?［J］. Curr Opin Pediatr, 2009,21（4）:486⁃490. doi: 10. 1097/MOP.0b013e32832cfd3b. |
| ［6］ | Draelos ZD. The science behind skin care: moisturizers［J］. J Cosmet Dermatol, 2018,17（2）:138⁃144. doi: 10. 1111/jocd.12490. |
| ［7］ | 许阳, 骆丹. 皮肤保湿功能与保湿剂的应用［J］. 国外医学（皮肤性病学分册）, 2004,30（3）:146⁃148. doi: 10.3760/cma.j.issn. 1673⁃4173.2004.03.004. |
| ［8］ | Del Rosso JQ. The role of skin care as an integral component in the management of acne vulgaris: part 1: the importance of cleanser and moisturizer ingredients, design, and product selection［J］. J Clin Aesthet Dermatol, 2013,6（12）:19⁃27. |
| ［9］ | 杨凯, 李海龙, 张强. 保湿剂在寻常性痤疮治疗中的辅助作用及相关研究进展［J］. 中国美容医学, 2019,28（8）:166⁃169. |
| ［10］ | van Zuuren EJ, Fedorowicz Z, Christensen R, et al. Emollients and moisturisers for eczema［J］. Cochrane Database Syst Rev, 2017,2（2）:CD012119. doi: 10.1002/14651858.CD012119.pub2. |
| ［11］ | Micali G, Paternò V, Cannarella R, et al. Evidence⁃based treatment of atopic dermatitis with topical moisturizers［J］. G Ital Dermatol Venereol, 2018,153（3）:396⁃402. doi: 10.23736/S0392⁃0488.18.05898⁃4. |
| ［12］ | Åkerström U, Reitamo S, Langeland T, et al. Comparison of moisturizing creams for the prevention of atopic dermatitis relapse: a randomized double⁃blind controlled multicentre clinical trial［J］. Acta Derm Venereol, 2015,95（5）:587⁃592. doi: 10.2340/00015555⁃2051. |
| ［13］ | Lee C, Bajor J, Moaddel T, et al. Principles of moisturizer product design［J］. J Drugs Dermatol, 2019,18（1s）:s89⁃s95. |
| ［14］ | Essendoubi M, Gobinet C, Reynaud R, et al. Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy［J］. Skin Res Technol, 2016,22（1）:55⁃62. doi: 10.1111/srt.12228. |
| ［15］ | Schrader A, Siefken W, Kueper T, et al. Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin［J］. Skin Pharmacol Physiol, 2012,25（4）:192⁃199. doi: 10.1159/000338190. |
| ［16］ | Coderch L, López O, de la Maza A, et al. Ceramides and skin function［J］. Am J Clin Dermatol, 2003,4（2）:107⁃129. doi: 10. 2165/00128071⁃200304020⁃00004. |
| ［17］ | Voigt J, Driver VR. Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: a systematic review and meta⁃analysis of randomized controlled trials［J］. Wound Repair Regen, 2012,20（3）:317⁃331. doi: 10. 1111/j.1524⁃475X.2012. 00777.x. |
| ［18］ | Kauth M, Trusova OV. Topical ectoine application in children and adults to treat inflammatory diseases associated with an impaired skin barrier: a systematic review［J］. Dermatol Ther （Heidelb）, 2022,12（2）:295⁃313. doi: 10.1007/s13555⁃021⁃00676⁃9. |
| ［19］ | Draelos ZD, Diaz I, Namkoong J, et al. Efficacy evaluation of a topical hyaluronic acid serum in facial photoaging［J］. Dermatol Ther （Heidelb）, 2021,11（4）:1385⁃1394. doi: 10.1007/s13555⁃021⁃00566⁃0. |
| ［20］ | Swaney MH, Kalan LR. Living in your skin: microbes, molecules, and mechanisms［J］. Infect Immun, 2021,89（4）:e00695⁃20. doi: 10.1128/IAI.00695⁃20. |
| ［21］ | Amakye N, Chan J, Ridd MJ. Emollient prescribing formularies and guidelines in England, 2021: a cross⁃sectional study［J］. Clin Exp Dermatol, 2022,47（8）:1502⁃1507. doi: 10.1111/ced. 15197. |
| ［22］ | Do L, Azizi N, Maibach H. Sensitive skin syndrome: an update［J］. Am J Clin Dermatol, 2020,21（3）:401⁃409. doi: 10.1007/s40257⁃019⁃00499⁃7. |
| ［23］ | Misery L, Weisshaar E, Brenaut E, et al. Pathophysiology and management of sensitive skin: position paper from the special interest group on sensitive skin of the International Forum for the Study of Itch （IFSI）［J］. J Eur Acad Dermatol Venereol, 2020,34（2）:222⁃229. doi: 10.1111/jdv.16000. |
| ［24］ | 何黎, 郑捷, 郝飞, 等. 中国敏感性皮肤诊治专家共识［J］. 中国皮肤性病学杂志, 2017,31（1）:1⁃4. doi: 10. 13735/j.cjdv.1001⁃7089.201611168. |
| ［25］ | 舒敏保湿类护肤品在敏感性皮肤中应用指南专家组. 舒敏保湿类护肤品在敏感性皮肤中的应用指南［J］. 中国皮肤性病学杂志, 2019,33（11）:1229⁃1231. doi: 10.13735/j.cjdv.1001⁃7089.201910016. |
| ［26］ | Proksch E. The role of emollients in the management of diseases with chronic dry skin［J］. Skin Pharmacol Physiol, 2008,21（2）:75⁃80. doi: 10.1159/000112957. |
| ［27］ | Purnamawati S, Indrastuti N, Danarti R, et al. The role of moisturizers in addressing various kinds of dermatitis: a review［J］. Clin Med Res, 2017,15（3⁃4）:75⁃87. doi: 10.3121/cmr.2017. 1363. |
| ［28］ | Elias PE. Optimizing emollient therapy for skin barrier repair in atopic dermatitis［J］. Ann Allergy Asthma Immunol, 2022,128（5）:505⁃511. doi: 10.1016/j.anai. 2022.01.012. |
| ［29］ | Lindh JD, Bradley M. Clinical effectiveness of moisturizers in atopic dermatitis and related disorders: a systematic review［J］. Am J Clin Dermatol, 2015,16（5）:341⁃359. doi: 10.1007/s40257⁃015⁃0146⁃4. |
| ［30］ | Draelos ZD. A clinical evaluation of the comparable efficacy of hyaluronic acid⁃based foam and ceramide⁃containing emulsion cream in the treatment of mild⁃to⁃moderate atopic dermatitis［J］. J Cosmet Dermatol, 2011,10（3）:185⁃188. doi: 10.1111/j.1473⁃2165.2011.00568.x. |
| ［31］ | Katoh N, Ohya Y, Ikeda M, et al. Clinical practice guidelines for the management of atopic dermatitis 2018［J］. J Dermatol, 2019,46（12）:1053⁃1101. doi: 10.1111/1346⁃8138.15090. |
| ［32］ | 中华医学会皮肤性病学分会免疫学组, 特应性皮炎协作研究中心. 中国特应性皮炎诊疗指南（2020版）［J］. 中华皮肤科杂志, 2020,53（2）:81⁃88. doi: 10.35541/cjd.20191000. |
| ［33］ | Marson JW, Baldwin HE. New concepts, concerns, and creations in acne［J］. Dermatol Clin, 2019,37（1）:1⁃9. doi: 10. 1016/j.det.2018.07.002. |
| ［34］ | Lain E, Andriessen AE. Choosing the right partner: complementing prescription acne medication with over⁃the⁃counter cleansers and moisturizers［J］. J Drugs Dermatol, 2020,19（11）:1069⁃1075. doi: 10.36849/JDD. 2020.5536. |
| ［35］ | 中国痤疮治疗指南专家组. 中国痤疮治疗指南（2019修订版）［J］. 临床皮肤科杂志, 2019,48（9）:583⁃588. doi: 10.16761/j.cnki.1000⁃4963.2019.09.020. |
| ［36］ | Yuan C, Ma Y, Wang Y, et al. Rosacea is associated with conjoined interactions between physical barrier of the skin and microorganisms: a pilot study［J］. J Clin Lab Anal, 2020,34（9）:e23363. doi: 10.1002/jcla.23363. |
| ［37］ | Medgyesi B, Dajnoki Z, Béke G, et al. Rosacea is characterized by a profoundly diminished skin barrier［J］. J Invest Dermatol, 2020,140（10）:1938⁃1950.e5. doi: 10.1016/j.jid.2020.02.025. |
| ［38］ | 中华医学会皮肤性病学分会玫瑰痤疮研究中心, 中国医师协会皮肤科医师分会玫瑰痤疮专业委员会. 中国玫瑰痤疮诊疗指南（2021版）［J］. 中华皮肤科杂志, 2021,54（4）:279⁃288. doi: 10.35541/cjd.20201078. |
| ［39］ | Sticherling M. Dermatology part 2: ichthyoses and psoriasis［J］. Handb Exp Pharmacol, 2020,261:153⁃175. doi: 10.1007/164_2019_345. |
| ［40］ | Lachapelle JM, Gimenez⁃Arnau A, Metz M, et al. Best practices, new perspectives and the perfect emollient: optimizing the management of contact dermatitis［J］. J Dermatolog Treat, 2018,29（3）:241⁃251. doi: 10.1080/09546634.2017.1370074. |
| ［41］ | González⁃Muñoz P, Conde⁃Salazar L, Vañó⁃Galván S. Allergic contact dermatitis caused by cosmetic products［J］. Actas Dermosifiliogr, 2014,105（9）:822⁃832. doi: 10.1016/j.ad.2013.12. 018. |
| ［42］ | Kunkiel K, Sojewska M, Feleszko W. Contact haptens in emollients marketed in two European countries （Poland and Spain）［J］. Allergol Immunopathol （Madr）, 2020,48（6）:814⁃818. doi: 10.1016/j.aller.2020.04.002. |
| ［43］ | Neena V, Asokan N, Jose R, et al. Prevalence of eczema among older persons: a population⁃based cross⁃sectional study［J］. Indian J Dermatol Venereol Leprol, 2023,89（3）:426⁃430. doi: 10.25259/IJDVL_990_19. |
| ［44］ | Norman RA. Xerosis and pruritus in the elderly: recognition and management［J］. Dermatol Ther, 2003,16（3）:254⁃259. doi: 10. 1046/j.1529⁃8019.2003.01635.x. |
| ［45］ | Benintende C, Boscaglia S, Dinotta F, et al. Treatment of ichthyosis vulgaris with a urea⁃based emulsion: videodermatoscopy and confocal microscopy evaluation［J］. G Ital Dermatol Venereol, 2017,152（6）:555⁃559. doi: 10.23736/S0392⁃0488.17.05743⁃1. |
| ［46］ | Kang SY, Um JY, Chung BY, et al. Moisturizer in patients with inflammatory skin diseases［J］. Medicina （Kaunas）, 2022,58（7）:888. doi: 10.3390/medicina58070888. |
| ［47］ | Blume⁃Peytavi U, Lavender T, Jenerowicz D, et al. Recommendations from a European roundtable meeting on best practice healthy infant skin care［J］. Pediatr Dermatol, 2016,33（3）:311⁃321. doi: 10.1111/pde.12819. |
| ［48］ | Visscher MO, Adam R, Brink S, et al. Newborn infant skin: physiology, development, and care［J］. Clin Dermatol, 2015,33（3）:271⁃280. doi: 10.1016/j.clindermatol.2014.12.003. |
| ［49］ | Barankin B, Silver SG, Carruthers A. The skin in pregnancy［J］. J Cutan Med Surg, 2002,6（3）:236⁃240. doi: 10.1177/1203475 40200600308. |
| ［50］ | Jiang W, Wang J, Zhang H, et al. Seasonal changes in the physiological features of healthy and sensitive skin［J］. J Cosmet Dermatol, 2022,21（6）:2581⁃2589. doi: 10. 1111/jocd.14476. |
| ［51］ | Newton H. Using emollients to promote safe and effective skin care for patients［J］. Nurs Stand, 2021,36（10）:77⁃82. doi: 10. 7748/ns.2021.e11687. |
| ［52］ | Wollenberg A, Barbarot S, Bieber T, et al. Consensus⁃based European guidelines for treatment of atopic eczema （atopic dermatitis） in adults and children: partⅠ［J］. J Eur Acad Dermatol Venereol, 2018,32（5）:657⁃682. doi: 10.1111/jdv.14891. |
| ［53］ | Brown A, Butcher M. A guide to emollient therapy［J］. Nurs Stand, 2005,19（24）:68,70,72. doi: 10.7748/ ns2005.02.19.24.68. c3813. |
| ［54］ | Del Rosso JQ, Lehman PA, Raney SG. Impact of order of application of moisturizers on percutaneous absorption kinetics: evaluation of sequential application of moisturizer lotions and azelaic acid gel 15% using a human skin model［J］. Cutis, 2009,83（3）:119⁃124. |
| ［55］ | Lodén M. The clinical benefit of moisturizers［J］. J Eur Acad Dermatol Venereol, 2005,19（6）:672⁃687. doi: 10.1111/j.1468⁃3083.2005.01326.x. |
| ［56］ | 裴新荣, 孙磊, 邢书霞. 《化妆品安全评估技术导则（2021年版）》解读［J］. 环境卫生学杂志, 2021,11（5）:442⁃446. doi: 10.13421/j.cnki.hjwsxzz.2021.05.009. |
| ［57］ | Sethi A, Kaur T, Malhotra SK, et al. Moisturizers: the slippery road［J］. Indian J Dermatol, 2016,61（3）:279⁃287. doi: 10.4103/0019⁃5154.182427. |
| ［58］ | 国家药品监督管理局. 儿童化妆品监督管理规定［Z/OL］. 2021⁃09⁃30. https://www.nmpa.gov.cn/xxgk/ggtg/qtggtg/202110081 71226187.html. |
| ［59］ | 中国医师协会皮肤科医师分会过敏性疾病专业委员会. 斑贴试验临床应用专家共识（2020修订版）［J］. 中华皮肤科杂志, 2020,53（4）:239⁃243. doi: 10.35541/cjd.20190873. |
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