中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (2): 165-169.doi: 10.35541/cjd.20200649
杨琦 郑捷
收稿日期:
2020-06-24
修回日期:
2021-01-18
发布日期:
2023-02-01
通讯作者:
郑捷
E-mail:jie-zheng2001@126.com
基金资助:
Yang Qi, Zheng Jie
Received:
2020-06-24
Revised:
2021-01-18
Published:
2023-02-01
Contact:
Zheng Jie
E-mail:jie-zheng2001@126.com
Supported by:
摘要: 【摘要】 银屑病易伴发心血管疾病,与动脉粥样硬化存在相似的致病机制,都涉及固有免疫的激活和自身反应性T细胞的活化。近年来,越来越多的生物制剂被运用于银屑病的系统治疗中,包括肿瘤坏死因子α、白细胞介素12/23和白细胞介素17A抑制剂,不同生物制剂的疗效、安全性及其对心血管疾病的影响也引起了皮肤科医生的重视。本文对银屑病和动脉粥样硬化共同的免疫机制,以及不同生物制剂对心血管疾病与相关代谢变化的影响进行了概述。
杨琦 郑捷. 生物制剂治疗对银屑病相关心血管疾病的影响[J]. 中华皮肤科杂志, 2023,56(2):165-169. doi:10.35541/cjd.20200649
Yang Qi, Zheng Jie. Effect of biologics on cardiovascular comorbidities of psoriasis[J]. Chinese Journal of Dermatology, 2023, 56(2): 165-169.doi:10.35541/cjd.20200649
[1] | Dattilo G, Imbalzano E, Casale M, et al. Psoriasis and cardiovascular risk: correlation between psoriasis and cardiovascular functional indices[J]. Angiology, 2018,69(1):31⁃37. doi: 10.1177/0003319717699329. |
[2] | Fernández⁃Armenteros JM, Gómez⁃Arbonés X, Buti⁃Soler M, et al. Psoriasis, metabolic syndrome and cardiovascular risk factors. A population⁃based study[J]. J Eur Acad Dermatol Venereol, 2019,33(1):128⁃135. doi: 10.1111/jdv.15159. |
[3] | Boehncke WH. Systemic inflammation and cardiovascular comorbidity in psoriasis patients: causes and consequences[J]. Front Immunol, 2018,9:579. doi: 10.3389/fimmu.2018.00579. |
[4] | Caiazzo G, Fabbrocini G, Di Caprio R, et al. Psoriasis, cardiovascular events, and biologics: lights and shadows[J]. Front Immunol, 2018,9:1668. doi: 10.3389/fimmu.2018.01668. |
[5] | Skov L, Thomsen SF, Kristensen LE, et al. Cause⁃specific mortality in patients with psoriasis and psoriatic arthritis[J]. Br J Dermatol, 2019,180(1):100⁃107. doi: 10.1111/bjd.16919. |
[6] | Egeberg A, Skov L, Joshi AA, et al. The relationship between duration of psoriasis, vascular inflammation, and cardiovascular events[J]. J Am Acad Dermatol, 2017,77(4):650⁃656.e3. doi: 10.1016/j.jaad.2017.06.028. |
[7] | Ramezani M, Zavattaro E, Sadeghi M. Evaluation of serum lipid, lipoprotein, and apolipoprotein levels in psoriatic patients: a systematic review and meta⁃analysis of case⁃control studies[J]. Postepy Dermatol Alergol, 2019,36(6):692⁃702. doi: 10.5114/ada.2019.91420. |
[8] | Wan MT, Shin DB, Hubbard RA, et al. Psoriasis and the risk of diabetes: a prospective population⁃based cohort study[J]. J Am Acad Dermatol, 2018,78(2):315⁃322. doi: 10.1016/j.jaad.2017. 10.050. |
[9] | Kong Y, Zhang S, Wu R, et al. New insights into different adipokines in linking the pathophysiology of obesity and psoriasis[J]. Lipids Health Dis, 2019,18(1):171. doi: 10.1186/s12944⁃019⁃1115⁃3. |
[10] | Baumer Y, Ng Q, Sanda GE, et al. Chronic skin inflammation accelerates macrophage cholesterol crystal formation and atherosclerosis[J]. JCI Insight, 2018,3(1):e97179. doi: 10.1172/jci.insight.97179. |
[11] | Herbert D, Franz S, Popkova Y, et al. High⁃fat diet exacerbates early psoriatic skin inflammation independent of obesity: saturated fatty acids as key players[J]. J Invest Dermatol, 2018,138(9):1999⁃2009. doi: 10.1016/j.jid.2018.03.1522. |
[12] | Schön MP. Adaptive and innate immunity in psoriasis and other inflammatory disorders[J]. Front Immunol, 2019,10:1764. doi: 10.3389/fimmu.2019.01764. |
[13] | Zhang Z, Meng P, Han Y, et al. Mitochondrial DNA⁃LL⁃37 complex promotes atherosclerosis by escaping from autophagic recognition[J]. Immunity, 2015,43(6):1137⁃1147. doi: 10.1016/j.immuni.2015.10.018. |
[14] | Lande R, Botti E, Jandus C, et al. The antimicrobial peptide LL37 is a T⁃cell autoantigen in psoriasis[J]. Nat Commun, 2014,5:5621. doi: 10.1038/ncomms6621. |
[15] | Balta I, Balta S, Demirkol S, et al. Elevated serum levels of endocan in patients with psoriasis vulgaris: correlations with cardiovascular risk and activity of disease[J]. Br J Dermatol, 2013,169(5):1066⁃1070. doi: 10.1111/bjd.12525. |
[16] | Lee S, Bartlett B, Dwivedi G. Adaptive immune responses in human atherosclerosis[J]. Int J MolSci, 2020,21(23):9322. doi: 10.3390/ijms21239322. |
[17] | Raggi P, Genest J, Giles JT, et al. Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions[J]. Atherosclerosis, 2018,276:98⁃108. doi: 10.1016/j.atherosclerosis. 2018.07.014. |
[18] | Ye J, Wang Y, Wang Z, et al. Roles and mechanisms of interleukin⁃12 family members in cardiovascular diseases: opportunities and challenges[J]. Front Pharmacol, 2020,11:129. doi: 10.3389/fphar.2020.00129. |
[19] | Allam G, Abdel⁃Moneim A, Gaber AM. The pleiotropic role of interleukin⁃17 in atherosclerosis[J]. Biomed Pharmacother, 2018,106:1412⁃1418. doi: 10.1016/j.biopha.2018.07.110. |
[20] | Ahlehoff O, Skov L, Gislason G, et al. Cardiovascular outcomes and systemic anti⁃inflammatory drugs in patients with severe psoriasis: 5⁃year follow⁃up of a Danish nationwide cohort[J]. J Eur Acad Dermatol Venereol, 2015,29(6):1128⁃1134. doi: 10. 1111/jdv.12768. |
[21] | Parisi R, Rutter MK, Lunt M, et al. Psoriasis and the risk of major cardiovascular events: cohort study using the clinical practice research datalink[J]. J Invest Dermatol, 2015,135(9):2189⁃2197. doi: 10.1038/jid.2015.87. |
[22] | Wu JJ, Joshi AA, Reddy SP, et al. Anti⁃inflammatory therapy with tumour necrosis factor inhibitors is associated with reduced risk of major adverse cardiovascular events in psoriasis[J]. J Eur Acad Dermatol Venereol, 2018,32(8):1320⁃1326. doi: 10. 1111/jdv.14951. |
[23] | Rungapiromnan W, Mason KJ, Lunt M, et al. Risk of major cardiovascular events in patients with psoriasis receiving biologic therapies: a prospective cohort study[J]. J Eur Acad Dermatol Venereol, 2020,34(4):769⁃778. doi: 10.1111/jdv.16018. |
[24] | Champs B, Degboé Y, Barnetche T, et al. Short⁃term risk of major adverse cardiovascular events or congestive heart failure in patients with psoriatic arthritis or psoriasis initiating a biological therapy: a meta⁃analysis of randomised controlled trials[J]. RMD Open, 2019,5(1):e000763. doi: 10.1136/rmdopen⁃ 2018⁃000763. |
[25] | Gordon KB, Langley RG, Gottlieb AB, et al. A phase III, randomized, controlled trial of the fully human IL⁃12/23 mAbbriakinumab in moderate⁃to⁃severe psoriasis[J]. J Invest Dermatol, 2012,132(2):304⁃314. doi: 10.1038/jid.2011.304. |
[26] | Lee MP, Desai RJ, Jin Y, et al. Association of ustekinumab vs TNF inhibitor therapy with risk of atrial fibrillation and cardiovascular events in patients with psoriasis or psoriatic arthritis[J]. JAMA Dermatol, 2019,155(6):700⁃707. doi: 10. 1001/jamadermatol.2019.0001. |
[27] | Rungapiromnan W, Yiu Z, Warren RB, et al. Impact of biologic therapies on risk of major adverse cardiovascular events in patients with psoriasis: systematic review and meta⁃analysis of randomized controlled trials[J]. Br J Dermatol, 2017,176(4):890⁃901. doi: 10.1111/bjd.14964. |
[28] | Aksentijevich M, Lateef SS, Anzenberg P, et al. Chronic inflammation, cardiometabolic diseases and effects of treatment: psoriasis as a human model[J]. Trends Cardiovasc Med, 2020,30(8):472⁃478. doi: 10.1016/j.tcm.2019.11.001. |
[29] | Mehta NN, Shin DB, Joshi AA, et al. Effect of 2 psoriasis treatments on vascular inflammation and novel inflammatory cardiovascular biomarkers: a randomized placebo⁃controlled trial[J]. Circ Cardiovasc Imaging, 2018,11(6):e007394. doi: 10.1161/ CIRCIMAGING.117.007394. |
[30] | Gelfand JM, Shin DB, Alavi A, et al. A phase IV, randomized, double⁃blind, placebo⁃controlled crossover study of the effects of ustekinumab on vascular inflammation in psoriasis (the VIP⁃U Trial)[J]. J Invest Dermatol, 2020,140(1):85⁃93. doi: 10.1016/j.jid.2019.07.679. |
[31] | Pirro M, Simental⁃Mendía LE, Bianconi V, et al. Effect of statin therapy on arterial wall inflammation based on 18F⁃FDG PET/CT: a systematic review and meta⁃analysis of interventional studies[J]. J Clin Med, 2019,8(1):118. doi: 10.3390/jcm8010118. |
[32] | Rivers JP, Powell⁃Wiley TM, Dey AK, et al. Visceral adiposity in psoriasis is associated with vascular inflammation by (18)F⁃Fluorodeoxyglucosepositron⁃emission tomography/computed tomography beyond cardiometabolic disease risk factors in an observational cohort study[J]. JACC Cardiovasc Imaging, 2018,11(2 Pt 2):349⁃357. doi: 10.1016/j.jcmg.2017.08.014. |
[33] | Kim BS, Lee WK, Pak K, et al. Ustekinumab treatment is associated with decreased systemic and vascular inflammation in patients with moderate⁃to⁃severe psoriasis: feasibility study using (18)F⁃fluorodeoxyglucose PET/CT[J]. J Am Acad Dermatol, 2019,80(5):1322⁃1331. doi: 10.1016/j.jaad.2018.03. 011. |
[34] | Gelfand JM, Shin DB, Duffin KC, et al. A Randomized placebo⁃controlled trial of secukinumab on aortic vascular inflammation in moderate⁃to⁃severe plaque psoriasis (VIP⁃S)[J]. J Invest Dermatol, 2020,140(9):1784⁃1793. doi: 10.1016/j.jid.2020.01. 025. |
[35] | Joshi AA, Lerman JB, Dey AK, et al. Association between aortic vascular inflammation and coronary artery plaque characteristics in psoriasis[J]. JAMA Cardiol, 2018,3(10):949⁃956. doi: 10. 1001/jamacardio.2018.2769. |
[36] | Williams MC, Kwiecinski J, Doris M, et al. Low⁃attenuation noncalcified plaque on coronary computed tomography angiography predicts myocardial infarction: results from the multicenter SCOT⁃HEART trial (Scottish computed tomography of the HEART)[J]. Circulation, 2020,141(18):1452⁃1462. doi: 10.1161/CIRCULATIONAHA.119.044720. |
[37] | Elnabawi YA, Dey AK, Goyal A, et al. Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study[J]. Cardiovasc Res, 2019,115(4):721⁃728. doi: 10.1093/cvr/cvz009. |
[38] | Oikonomou EK, Marwan M, Desai MY, et al. Non⁃invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post⁃hoc analysis of prospective outcome data[J]. Lancet, 2018,392(10151):929⁃939. doi: 10.1016/S0140⁃6736(18)31114⁃0. |
[39] | Elnabawi YA, Oikonomou EK, Dey AK, et al. Association of biologic therapy with coronary inflammation in patients with psoriasis as assessed by perivascular fat attenuation index[J]. JAMA Cardiol, 2019,4(9):885⁃891. doi: 10.1001/jamacardio. 2019.2589. |
[40] | Osto E, Piaserico S, Maddalozzo A, et al. Impaired coronary flow reserve in young patients affected by severe psoriasis[J]. Atherosclerosis, 2012,221(1):113⁃117. doi: 10.1016/j.atherosclerosis.2011.12.015. |
[41] | Alba BK, Greaney JL, Ferguson SB, et al. Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide⁃dependent vasodilation[J]. Am J Physiol Heart CircPhysiol, 2018,314(2):H343⁃H349. doi: 10.1152/ajpheart.00446.2017. |
[42] | Piaserico S, Osto E, Famoso G, et al. Treatment with tumor necrosis factor inhibitors restores coronary microvascular function in young patients with severe psoriasis[J]. Atherosclerosis, 2016,251:25⁃30. doi: 10.1016/j.atherosclerosis.2016.05.036. |
[43] | Choi H, Uceda DE, Dey AK, et al. Application of non⁃invasive imaging in inflammatory disease conditions to evaluate subclinical coronary artery disease[J]. Curr Rheumatol Rep, 2019,22(1):1. doi: 10.1007/s11926⁃019⁃0875⁃0. |
[44] | Von Stebut E, Reich K, Thaçi D, et al. Impact of secukinumab on endothelial dysfunction and other cardiovascular disease parameters in psoriasis patients over 52 weeks[J]. J Invest Dermatol, 2019,139(5):1054⁃1062. doi: 10.1016/j.jid.2018.10. 042. |
[45] | Groenendyk JW, Shukla P, Dey AK, et al. Association of aortic vascular uptake of (18)FDG by PET/CT and aortic wall thickness by MRI in psoriasis: a prospective observational study[J]. Eur J Nucl Med Mol Imaging, 2019,46(12):2488⁃2495. doi: 10.1007/s00259⁃019⁃04454⁃w. |
[46] | Vlachopoulos C, Gravos A, Georgiopoulos G, et al. The effect of TNF⁃a antagonists on aortic stiffness and wave reflections: a meta⁃analysis[J]. Clin Rheumatol, 2018,37(2):515⁃526. doi: 10.1007/s10067⁃017⁃3657⁃y. |
[47] | Eder L, Joshi AA, Dey AK, et al. Association of tumor necrosis factor inhibitor treatment with reduced indices of subclinical atherosclerosis in patients with psoriatic disease[J]. Arthritis Rheumatol, 2018,70(3):408⁃416. doi: 10.1002/art.40366. |
[48] | Hjuler KF, Bøttcher M, Vestergaard C, et al. Association between changes in coronary artery disease progression and treatment with biologic agents for severe psoriasis[J]. JAMA Dermatol, 2016,152(10):1114⁃1121. doi: 10.1001/jamadermatol.2016.1984. |
[49] | Toussirot E. The interrelations between biological and targeted synthetic agents used in inflammatory joint diseases, and obesity or body composition[J]. Metabolites, 2020,10(3). doi: 10.3390/metabo10030107. |
[50] | Takamura S, Takahashi A, Inoue Y, et al. Effects of tumor necrosis factor⁃α, interleukin⁃23 and interleukin⁃17A inhibitors on bodyweight and body mass index in patients with psoriasis[J]. J Dermatol, 2018,45(9):1130⁃1134. doi: 10.1111/1346⁃8138.14526. |
[1] | 何谐 栗玉珍. 靶向JAK-STAT信号通路治疗银屑病的研究进展[J]. 中华皮肤科杂志, 2023, 56(3): 273-278. |
[2] | 中华医学会皮肤性病学分会银屑病专业委员会. 银屑病生物制剂达标治疗专家共识[J]. 中华皮肤科杂志, 2023, 56(3): 191-203. |
[3] | 周健 俞晨 王刚. 司库奇尤单抗治疗13例难治性局限性脓疱型银屑病的临床疗效与安全性观察[J]. 中华皮肤科杂志, 2023, 56(3): 247-251. |
[4] | 胡琨 杨晶 王巧林 陈军臣 张谧 朱武 张斌 窦冠珅 Wendong Chen, 匡叶红. [开放获取] 依奇珠单抗治疗银屑病短期疗效的单中心病例回顾性研究[J]. 中华皮肤科杂志, 2023, 56(3): 210-215. |
[5] | 罗帅寒天 龙海 陆前进. 2022年系统性红斑狼疮研究新进展[J]. 中华皮肤科杂志, 2023, 56(3): 266-269. |
[6] | 阮诗钒 张鹏 林婷婷 罗仁炜 鲍思怡 薛晨瑶 童泽群 张亮亮 龚婷 纪超. 寻常型银屑病与血脂异常的相关性研究[J]. 中华皮肤科杂志, 2023, 0(3): 20220322-e20220322. |
[7] | 苑辰 闫言 王宝玺. 反常性痤疮的生物治疗进展[J]. 中华皮肤科杂志, 2023, 56(3): 270-273. |
[8] | 王召阳 向欣 陈云刘 苗朝阳 赵欣荣 张振华 刘元香 马琳 徐子刚. 生物制剂与甲氨蝶呤治疗儿童重度斑块状银屑病疗效及安全性比较[J]. 中华皮肤科杂志, 2023, 56(2): 112-117. |
[9] | 贾元源 毛秋雨 杨婧怡 闵玮. 度普利尤单抗治疗中重度老年特应性皮炎临床疗效观察[J]. 中华皮肤科杂志, 2023, 56(2): 125-129. |
[10] | 田晶 梁源 马琳. 度普利尤单抗治疗儿童特应性皮炎的研究进展[J]. 中华皮肤科杂志, 2023, 0(2): 20210730-e20210730. |
[11] | 陈良宏 孙艳 王敬玉 吴严. 本维莫德在皮肤病中的研究进展[J]. 中华皮肤科杂志, 2023, 0(2): 20210875-e20210875. |
[12] | 黄贺 张学军. 白细胞介素23抑制剂古塞奇尤单抗在银屑病治疗中的应用[J]. 中华皮肤科杂志, 2023, 56(2): 181-184. |
[13] | 杨莹 郭青 侯素春 闵雪 田佳彬 乔朱卉 林佳琳 王小飞 乌兰图雅 张振颖 李正风 王彬 刘晓明. 【开放获取】 接受生物制剂治疗的银屑病患者COVID-19疫苗接种情况及对原发病影响的单中心横断面研究[J]. 中华皮肤科杂志, 2023, 56(1): 59-63. |
[14] | 郑佳媛 余炳前 陈显侠 骆志成. 成人寻常型银屑病瘙痒特征及对生活质量的影响调查[J]. 中华皮肤科杂志, 2022, 55(9): 790-794. |
[15] | 肖春英 王刚. 朗格汉斯细胞在银屑病中的作用研究进展[J]. 中华皮肤科杂志, 2022, 55(9): 830-834. |
|