中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (2): 161-164.doi: 10.35541/cjd.20220325

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皮肌炎的早期诊断和内脏损伤早期识别

杨骥    徐欣植    李明   

  1. 复旦大学附属中山医院皮肤科，上海  200032
  • 收稿日期:2022-05-09 修回日期:2022-10-17 发布日期:2023-02-01
  • 通讯作者: 杨骥 E-mail:yang.ji@zs-hospital.sh.cn
  • 基金资助:
    国家自然科学基金（82073436）；上海市科技计划项目（20ZR1411500、19411962500）；上海市科研项目临床研究专项（202140271）；复旦大学“卓越2025”人才培育计划-卓学优秀人才层次；医苑新星-上海市杰出青年医学人才培养资助计划；上海人才发展基金

Early diagnosis of dermatomyositis and early recognition of visceral injury

Yang Ji, Xu Xinzhi, Li Ming   

  1. Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
  • Received:2022-05-09 Revised:2022-10-17 Published:2023-02-01
  • Contact: Yang Ji E-mail:yang.ji@zs-hospital.sh.cn
  • Supported by:
    National Natural Science Foundation of China （82073436）; Medical Guide Project from Science and Technology Commission of Shanghai Municipality （CN） （20ZR1411500, 19411962500）; Special Clinical Research Project of Shanghai Municipal Health Commission （202140271）; Zhuoxue Plan of Fudan University; Outstanding Youth Medical Talents of Shanghai "Rising Stars of Medical Talent" Youth Development Program; Shanghai Talent Development Fund

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摘要： 【摘要】 皮肌炎是一种临床常见的自身免疫性疾病，常有肌肉和肺的累及，也常合并恶性肿瘤，肺累及常是致命性的。因此，早期诊断及治疗，对减少肌肉和肺的损伤、识别和诊治合并的恶性肿瘤、提高患者预后和生存率有极大帮助。皮肌炎的异质性强，临床表现多种多样，本文论述皮肌炎合并急性肺间质性纤维化、发生吞咽困难、合并恶性肿瘤的高风险因素，总结出“皮疹 + 甲皱血管 + 肌炎抗体”的联合模式有助于早期诊断皮肌炎，早期识别重要内脏损害风险和肿瘤，早期干预，提高患者的整体生存率。

关键词: 皮肌炎, 肺疾病, 间质性, 恶性肿瘤, 肌炎抗体, 早期诊断

Abstract: 【Abstract】 Dermatomyositis, a common autoimmune disease in clinical practice, often involves muscles and lungs, and can be complicated by malignant tumors, and the lung involvement can be fatal. Therefore, early diagnosis and treatment of dermatomyositis is of great benefit for the reduction of muscle and lung injury, early recognition and management of malignant tumors, and improvement of prognosis and survival rate of patients. However, the heterogeneity and various clinical manifestations of dermatomyositis pose challenges to early diagnosis. This article describes risk factors for dermatomyositis complicated by rapidly progressive pulmonary interstitial fibrosis, dysphagia or malignant tumors, and proposes a mode of "rashes + nailfold capillary abnormalities + myositis antibodies" for the early diagnosis of dermatomyositis, early recognition of important visceral injury and tumors, and early management, in order to improve overall survival rate of patients.

Key words: Dermatomyositis, Lung diseases, interstitial, Neoplasms, Myositis antibodies, Early diagnosis

中图分类号: 

  • R593.26

引用本文

杨骥 徐欣植 李明. 皮肌炎的早期诊断和内脏损伤早期识别[J]. 中华皮肤科杂志, 2023,56(2):161-164. doi:10.35541/cjd.20220325

Yang Ji, Xu Xinzhi, Li Ming. Early diagnosis of dermatomyositis and early recognition of visceral injury[J]. Chinese Journal of Dermatology, 2023, 56(2): 161-164.doi:10.35541/cjd.20220325