中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (3): 276-279.doi: 10.35541/cjd.20200108

• 综述 • 上一篇    

皮肌炎伴发恶性肿瘤的研究进展

吕玲    吕小岩   

  1. 四川大学华西医院皮肤性病科,成都  610041
  • 收稿日期:2020-02-13 修回日期:2021-01-03 发布日期:2022-03-03
  • 通讯作者: 吕小岩 E-mail:clazhou@126.com
  • 作者简介:作者希望能尽快开具录用证明,11月1日前是否可以?

Dermatomyositis with malignancy: an update

Lyu Ling, Lyu Xiaoyan   

  1. Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2020-02-13 Revised:2021-01-03 Published:2022-03-03
  • Contact: Lyu Xiaoyan E-mail:clazhou@126.com

摘要: 【摘要】 皮肌炎伴发恶性肿瘤是皮肌炎的一个亚型,伴发恶性肿瘤为皮肌炎预后不良的主要因素。恶性肿瘤高危发病时间为皮肌炎诊断前后1年内。与经典型皮肌炎相比,皮肌炎伴发恶性肿瘤具有患者年龄>50岁、Heliotrope征、皮肤坏死及肌炎特异性抗体抗转录中介因子1γ抗体、抗核基质蛋白2抗体阳性等典型的临床特点,这些特点提示需进行恶性肿瘤的筛查或密切监测随访。

关键词: 皮肌炎, 肿瘤, 自身抗体, 诊断, 预后

Abstract: 【Abstract】 Dermatomyositis with malignancy is a subtype of dermatomyositis, and the concurrence of malignancy is a major factor for poor prognosis of dermatomyositis. Malignancy usually occurs within 1 year before or after the diagnosis of dermatomyositis. Compared with classic dermatomyositis, dermatomyositis with malignancy mostly occurs in patients aged >50 years, and is typically characterized by the heliotrope sign, skin necrosis and presence of myositis-specific antibodies such as anti-transcriptional intermediary factor-1γ and anti-nuclear matrix protein-2 antibodies, etc. Thorough screening for malignancy or close monitoring and follow-up are necessary in patients with dermatomyositis.

Key words: Dermatomyositis, Neoplasms, Autoantibodies, Diagnosis, Prognosis

引用本文

吕玲 吕小岩. 皮肌炎伴发恶性肿瘤的研究进展[J]. 中华皮肤科杂志, 2022,55(3):276-279. doi:10.35541/cjd.20200108

Lyu Ling, Lyu Xiaoyan. Dermatomyositis with malignancy: an update[J]. Chinese Journal of Dermatology, 2022, 55(3): 276-279.doi:10.35541/cjd.20200108