中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (9): 790-794.doi: 10.35541/cjd.20210153

• 研究报道 • 上一篇    下一篇

成人寻常型银屑病瘙痒特征及对生活质量的影响调查

郑佳媛    余炳前    陈显侠    骆志成   

  1. 兰州大学第二医院皮肤科，兰州  730000
  • 收稿日期:2021-02-22 修回日期:2022-03-17 发布日期:2022-09-02
  • 通讯作者: 骆志成 E-mail:luozhich@lzu.edu.cn

Characteristics of pruritus in adult patients with psoriasis vulgaris and its effect on quality of life

Zheng Jiayuan, Yu Bingqian, Chen Xianxia, Luo Zhicheng   

  • Received:2021-02-22 Revised:2022-03-17 Published:2022-09-02
  • Contact: Luo Zhicheng E-mail:luozhich@lzu.edu.cn

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摘要： 【摘要】 目的 调查成人寻常型银屑病患者瘙痒的流行程度及临床特征，评估瘙痒对睡眠和生活质量的影响。方法 2020年1 - 12月在兰州大学第二医院采用医师评估和问卷调查相结合的方式，评估291例寻常型银屑病患者的瘙痒特征、睡眠及生活质量。运用二元Logistic回归分析影响瘙痒的危险因素，多元线性回归分析影响睡眠及生活质量的相关因素。结果 291例寻常型银屑病患者，男184例（63.23%），女107例（36.77%），年龄M（Q1，Q3）为37.00（28.00，50.00）岁。258例（88.64%）有瘙痒症状，瘙痒程度以中度多见。皮损严重程度（OR = 1.252，95% CI 1.114 ~ 1.407，P＜0.001）是患者瘙痒的主要危险因素。银屑病面积和严重程度指数与瘙痒数字评价量表（NRS）评分（r = 0.65，P＜0.001）、5-D′S评分（r = 0.65，P＜0.001）、匹兹堡睡眠质量指数量表（PSQI）评分（r = 0.48，P＜0.001）及皮肤病生活质量指数量表（DLQI）评分（r = 0.63，P＜0.001）均存在正相关，瘙痒严重程度NRS评分与DLQI评分（r = 0.61，P＜0.001）和PSQI评分（r = 0.55，P＜0.001）存在正相关，5-D′S评分与DLQI评分（r = 0.62，P＜0.001）和PSQI评分（r = 0.64，P＜0.001）均存在正相关。结论 大部分成人寻常型银屑病患者存在中等程度瘙痒；疾病严重程度显著影响患者的瘙痒严重程度，瘙痒对睡眠和生活质量有较大影响。

关键词: 银屑病, 瘙痒症, 生活质量, 睡眠, 影响因素分析, 问卷调查

Abstract: 【Abstract】 Objective To investigate the prevalence and clinical characteristics of pruritus in adult patients with psoriasis vulgaris, and to evaluate the effect of pruritus on sleep and quality of life. Methods From January 2020 to December 2020, 291 patients with psoriasis vulgaris were enrolled in Lanzhou University Second Hospital, and characteristics of pruritus as well as quality of sleep and life were evaluated by physicians directly or through a questionnaire. Binary logistic regression analysis was performed to analyze risk factors for pruritus, and multivariate linear regression to analyze related factors affecting sleep and quality of life. Results Among the 291 patients with psoriasis vulgaris, 184 （63.23%） were males and 107 （36.77%） were females, with the age （M ［Q1, Q3］） being 37.00 （28.00, 50.00） years; 258（88.64%） had the itching symptom, and the severity of itching was usually moderate. The severity of skin lesions was the main risk factor for pruritus （OR = 1.252, 95% CI: 1.114－1.407, P < 0.001）. Psoriasis area and severity index was positively correlated with pruritus numerical rating scale （NRS） score （r = 0.65, P < 0.001）, 5-D′S score （r =0.65, P < 0.001）, Pittsburgh sleep quality index （PSQI） score （r = 0.48, P < 0.001） and dermatology life quality index （DLQI） score （r = 0.63, P < 0.001）, the pruritus NRS score was positively correlated with the DLQI score （r = 0.61, P < 0.001） and PSQI score （r = 0.55, P < 0.001）, and the 5-D′S score was positively correlated with the DLQI score （r = 0.62, P < 0.001） and PSQI score （r = 0.64, P < 0.001）. Conclusion Most adult patients with psoriasis vulgaris have moderate pruritus; the severity of disease markedly affects the severity of pruritus, and pruritus exerts a major impact on sleep and quality of life.

Key words: Psoriasis, Pruritus, Quality of life, Sleep, Root cause analysis, Questionnaires