朗格汉斯细胞在银屑病中的作用研究进展

doi:10.35541/cjd.20200279

中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (9): 830-834.doi: 10.35541/cjd.20200279

朗格汉斯细胞在银屑病中的作用研究进展

肖春英王刚

第四军医大学西京皮肤医院，西安 710032

收稿日期:2020-03-19 修回日期:2020-10-21 发布日期:2022-09-02
通讯作者: 王刚 E-mail:xjwgang@fmmu.edu.cn
基金资助:
国家自然科学基金（81803125）

Roles of Langerhans cells in psoriasis

Xiao Chunying, Wang Gang

Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi′an 710032, China

Received:2020-03-19 Revised:2020-10-21 Published:2022-09-02
Contact: Wang Gang E-mail:xjwgang@fmmu.edu.cn
Supported by:
National Natural Science Foundation of China（81803125）

摘要/Abstract

摘要： 【摘要】朗格汉斯细胞（LC）是表皮内重要的免疫细胞，具有抗原提呈功能，在炎症状态下经过成熟、活化后，迁移至局部淋巴结并活化初始T细胞，启动免疫应答。近年对LC在银屑病发病中的研究显示，LC具有促进炎症和抑制炎症的双重作用。对LC起源的研究显示，LC有两个亚群，分别具有促炎和抑炎作用，参与不同的免疫应答过程，可能与银屑病免疫异常有关。本文综述LC在银屑病中的研究进展。

关键词: 银屑病, 朗格汉斯细胞, 亚群

Abstract: 【Abstract】 Langerhans cells （LC） are important immune cells with antigen-presenting functions in the epidermis. After maturation and activation in an inflammatory state, LC can migrate to local lymph nodes and activate initial T cells to initiate the immune response. Recent studies on the role of LC in pathogenesis of psoriasis have shown that LC play both pro- and anti-inflammatory roles. Studies on the origin of LC have shown that two subsets of LC exert pro- and anti-inflammatory effects respectively, and participate in different immune response processes, which may be related to immune abnormalities in psoriasis. This review systematically elaborates research advances in the role of LC in psoriasis.

Key words: Psoriasis, Langerhans cells, Subsets

肖春英王刚. 朗格汉斯细胞在银屑病中的作用研究进展[J]. 中华皮肤科杂志, 2022,55(9):830-834. doi:10.35541/cjd.20200279

Xiao Chunying, Wang Gang. Roles of Langerhans cells in psoriasis[J]. Chinese Journal of Dermatology, 2022, 55(9): 830-834.doi:10.35541/cjd.20200279

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朗格汉斯细胞在银屑病中的作用研究进展

Roles of Langerhans cells in psoriasis

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