中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (2): 181-184.doi: 10.35541/cjd.20200712

• 综述 • 上一篇    下一篇

白细胞介素23抑制剂古塞奇尤单抗在银屑病治疗中的应用

黄贺    张学军   

  1. 安徽医科大学第一附属医院皮肤性病科,合肥  230022
  • 收稿日期:2020-07-13 修回日期:2021-02-20 发布日期:2023-02-01
  • 通讯作者: 张学军 E-mail:ayzxj@vip.sina.com

Application of the interleukin-23 inhibitor guselkumab in the treatment of psoriasis

Huang He, Zhang Xuejun   

  1. Department of Dermatology and Venereology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
  • Received:2020-07-13 Revised:2021-02-20 Published:2023-02-01
  • Contact: Zhang Xuejun E-mail:ayzxj@vip.sina.com

摘要: 【摘要】 古塞奇尤单抗作为首个靶向白细胞介素23的抑制剂,在多项随机对照临床试验中对中重度银屑病患者的治疗显示出良好的疗效和安全性,能显著改善患者的生活质量。该文综述白细胞介素23和其抑制剂的作用机制及在银屑病治疗中的应用。

关键词: 银屑病, 白细胞介素23, 古塞奇尤单抗

Abstract: 【Abstract】 Guselkumab is the first monoclonal antibody that selectively targets interleukin (IL)-23. Several randomized controlled clinical trials have demonstrated that it is highly effective and safe in the treatment of moderate to severe plaque psoriasis, and can significantly improve the quality of life of patients. This review summarizes the action mechanisms of IL-23 and guselkumab, as well as the application of guselkumab in the treatment of psoriasis.

Key words: Psoriasis, Interleukin-23, Guselkumab

引用本文

黄贺 张学军. 白细胞介素23抑制剂古塞奇尤单抗在银屑病治疗中的应用[J]. 中华皮肤科杂志, 2023,56(2):181-184. doi:10.35541/cjd.20200712

Huang He, Zhang Xuejun. Application of the interleukin-23 inhibitor guselkumab in the treatment of psoriasis[J]. Chinese Journal of Dermatology, 2023, 56(2): 181-184.doi:10.35541/cjd.20200712