新生儿线状IgA大疱性皮病

doi:10.35541/cjd.20210502

中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (2): 146-148.doi: 10.35541/cjd.20210502

新生儿线状IgA大疱性皮病

尹光文¹ 耿朦朦¹ 崔燕² 张守民³ 李冬芹¹ 程秀永²

¹郑州大学第一附属医院皮肤科，郑州 450052；²郑州大学第一附属医院新生儿重症科，郑州 450052；³河南省人民医院皮肤科，郑州 450003

收稿日期:2021-07-06 修回日期:2022-01-18 发布日期:2023-02-01
通讯作者: 尹光文 E-mail:gwyin67@126.com

Neonatal linear IgA bullous dermatosis

Yin Guangwen¹, Geng Mengmeng¹, Cui Yan², Zhang Shoumin³, Li Dongqin¹, Cheng Xiuyong²

¹Department of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; ²Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; ³Department of Dermatology, Henan Provincial People′s Hospital, Zhengzhou 450003, China

Received:2021-07-06 Revised:2022-01-18 Published:2023-02-01
Contact: Yin Guangwen E-mail:gwyin67@126.com

摘要/Abstract

摘要： 【摘要】患儿男，生后10 d，因皮肤红斑、水疱6 d就诊入院。皮肤科检查：全身皮肤散在或融合分布红斑，在正常皮肤或红斑基础上可见大小不等的紧张性水疱，部分水疱破溃、糜烂；口腔黏膜可见血疱、红色糜烂面。组织病理检查示表皮下水疱，疱内可见中性粒细胞及少量嗜酸性粒细胞。直接免疫荧光检查显示：沿基底膜带有均质型线状IgA和颗粒状C3沉积，IgG阴性。诊断：新生儿线状IgA大疱性皮病。给予营养支持、防感染等综合治疗后，皮肤红斑、水疱消退，黏膜损害减轻出院。患儿出院后16个月电话随访，一般情况良好，皮肤黏膜皮损消退、愈合，无新发皮疹，生长发育正常。

关键词: 线状IgA大疱性皮病, 新生儿

Abstract: 【Abstract】 A 10-day-old male infant presented with skin erythema and blisters for 6 days. Skin examination showed scattered or confluent erythema all over the body, tense blisters of varying sizes on the normal skin or an erythematous base, and some blisters were ulcerated and erosive; bloody bullae and erythematous erosive patches could be seen on the oral mucosa. Histopathological examination revealed subepidermal blisters, and there were some neutrophils and a few eosinophils in the blisters. Direct immunofluorescence assay showed homogeneous linear IgA and granular C3 deposits along the basement membrane zone, without IgG deposits. The diagnosis of neonatal linear IgA bullous dermatosis was confirmed. After comprehensive treatments including nutritional support and anti-infection treatment, skin erythema and blisters subsided, and the mucosal damage was attenuated. The telephone follow-up 16 months after discharge showed that the infant was in good general condition with normal growth and development, and the oral mucosal lesions had subsided and healed, without new skin lesions.

Key words: Linear IgA bullous dermatosis, Neonate

尹光文耿朦朦崔燕张守民李冬芹程秀永. 新生儿线状IgA大疱性皮病[J]. 中华皮肤科杂志, 2023,56(2):146-148. doi:10.35541/cjd.20210502

Yin Guangwen, Geng Mengmeng, Cui Yan, Zhang Shoumin, Li Dongqin, Cheng Xiuyong. Neonatal linear IgA bullous dermatosis[J]. Chinese Journal of Dermatology, 2023, 56(2): 146-148.doi:10.35541/cjd.20210502

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新生儿线状IgA大疱性皮病

Neonatal linear IgA bullous dermatosis

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