BP180相关自身免疫性水疱病的研究进展

doi:10.3760/cma.j.issn.0412-4030.2019.01.017

中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (1): 50-52.doi: 10.3760/cma.j.issn.0412-4030.2019.01.017

BP180相关自身免疫性水疱病的研究进展

李锁冯素英

中国医学科学院北京协和医学院皮肤病医院皮肤科江苏省皮肤病与性病学重点实验室，南京 210042

收稿日期:2018-06-04 修回日期:2018-07-24 发布日期:2019-01-02
通讯作者: 冯素英 E-mail:fengsy@pumcderm.cams.cn
基金资助:
中国医学科学院医学与健康科技创新工程项目（CIFMS?2017?I2M?1?017）

BP180-related autoimmune blistering diseases

Li Suo, Feng Suying

Department of Dermatology, Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China

Received:2018-06-04 Revised:2018-07-24 Published:2019-01-02
Contact: Feng Suying E-mail:fengsy@pumcderm.cams.cn
Supported by:
CAMS Innovation Fund for Medical Sciences （CIFMS?2017?I2M?1?017）

摘要/Abstract

摘要： BP180相关自身免疫性水疱病包括大疱性类天疱疮、扁平苔藓样类天疱疮、线状IgA大疱性皮病、妊娠类天疱疮和瘢痕性类天疱疮。BP180胞外区含有多个自身抗体反应的位点，目前研究显示，BP180上相关自身免疫性水疱病靶位呈现出异质性，并且同一种疾病不同临床表现也与靶位异质性有关，然而异质性机制仍有待于进一步研究和探讨。

关键词: 类天疱疮, 大疱性；妊娠性类天疱疮；类天疱疮, 良性黏膜；线状IgA大疱性皮病； BP180

Abstract: BP180-related autoimmune blistering diseases include bullous pemphigoid, lichen planus pemphigoides, linear IgA bullous dermatosis, pemphigoid gestationis and cicatricial pemphigoid. There are multiple autoantibody-reactive sites on the extracellular region of BP180. Current studies show that there is heterogeneity in the autoimmune blistering disease-related target sites on BP180, and different clinical manifestations of the same disease are related to the heterogeneity of target sites. However, further studies and analysis are still needed for the mechanism of the heterogeneity.

Key words: Pemphigoid, bullous, Pemphigoid gestationis, Pemphigoid, benign mucous membrane, Linear IgA bullous dermatosis, BP180

李锁冯素英. BP180相关自身免疫性水疱病的研究进展[J]. 中华皮肤科杂志, 2019,52(1):50-52. doi:10.3760/cma.j.issn.0412-4030.2019.01.017

Li Suo, Feng Suying. BP180-related autoimmune blistering diseases[J]. Chinese Journal of Dermatology, 2019, 52(1): 50-52.doi:10.3760/cma.j.issn.0412-4030.2019.01.017

参考文献 32

［1］	Tasanen K, Tunggal L, Chometon G, et al. Keratinocytes from patients lacking collagen XVII display a migratory phenotype［J］. Am J Pathol, 2004,164（6）:2027⁃2038. doi: 10.1016/S0002⁃9440（10）63762⁃5.
［2］	Natsuga K, Watanabe M, Nishie W, et al. Life before and beyond blistering: the role of collagen XVII in epidermal physiology［J/OL］. Exp Dermatol, 2018.［2018⁃04⁃10］. https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13550. doi: 10.1111/exd.13550. ［published online ahead of print Mar 31, 2018］.
［3］	Powell AM, Sakuma⁃Oyama Y, Oyama N, et al. Collagen XVII/BP180: a collagenous transmembrane protein and component of the dermoepidermal anchoring complex［J］. Clin Exp Dermatol, 2005,30（6）:682⁃687. doi: 10.1111/j.1365⁃2230.2005.01937.x.
［4］	Zillikens D. BP180 as the common autoantigen in blistering diseases with different clinical phenotypes［J］. Keio J Med, 2002,51（1）:21⁃28.
［5］	Amber KT, Murrell DF, Schmidt E, et al. Autoimmune subepi⁃dermal bullous diseases of the skin and mucosae: clinical features, diagnosis, and management［J］. Clin Rev Allergy Immunol, 2018,54（1）:26⁃51. doi: 10.1007/s12016⁃017⁃8633⁃4. doi: 10.1007/ s12016⁃017⁃8633⁃4.
［6］	Lamberts A, Meijer JM, Jonkman MF. Nonbullous pemphigoid: a systematic review［J］. J Am Acad Dermatol, 2018,78（5）:989⁃995. doi: 10.1016/j.jaad.2017.10.035.
［7］	Cozzani E, Gasparini G, Burlando M, et al. Atypical presentations of bullous pemphigoid: clinical and immunopathological aspects［J］. Autoimmun Rev, 2015,14（5）:438⁃445. doi: 10.1016/j.autrev. 2015.01.006.
［8］	李锁, 李志量, 荆可, 等. 盐裂皮肤间接免疫荧光及BP180NC16a酶联免疫吸附测定在大疱性类天疱疮诊断中的意义［J］. 中华皮肤科杂志, 2018,51（1）:10⁃13. doi: 10.3760/cma.j.issn.0412⁃4030.2018.01.003.
［9］	Zillikens D, Rose PA, Balding SD, et al. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies［J］. J Invest Dermatol, 1997,109（4）:573⁃579.
［10］	Hammers CM, Stanley JR. Mechanisms of disease: pemphigus and bullous pemphigoid［J］. Annu Rev Pathol, 2016,11:175⁃197. doi: 10.1146/annurev⁃pathol⁃012615⁃044313.
［11］	Lin L, Hwang BJ, Culton DA, et al. Eosinophils mediate tissue injury in the autoimmune skin disease bullous pemphigoid［J］. J Invest Dermatol, 2018,138（5）:1032⁃1043. doi: 10.1016/j.jid.2017. 11.031.
［12］	Hofmann S, Thoma⁃Uszynski S, Hunziker T, et al. Severity and phenotype of bullous pemphigoid relate to autoantibody profile against the NH2⁃ and COOH⁃terminal regions of the BP180 ectodomain［J］. J Invest Dermatol, 2002,119（5）:1065⁃1073. doi: 10.1046/j.1523⁃1747.2002.19529.x.
［13］	Zhao CY, Murrell DF. Advances in understanding and managing bullous pemphigoid［J］. F1000Res, 2015,4. pii: F1000 Faculty Rev⁃1313. doi: 10.12688/f1000research.6896.1.
［14］	Kamaguchi M, Iwata H, Ujiie H, et al. High of collagen XVII compensates for its depletion induced by pemphigoid IgG in the oral mucosa［J］. J Invest Dermatol, 2018,138（8）:1707⁃1715. doi: 10.1016/j.jid.2018.03.002.
［15］	Izumi K, Nishie W, Mai Y, et al. Autoantibody profile differentiates between inflammatory and noninflammatory bullous pemphigoid［J］. J Invest Dermatol, 2016,136（11）:2201⁃2210. doi: 10.1016/j.jid.2016.06.622.
［16］	Chijiwa C, Takeoka S, Kamata M, et al. Decrease in eosinophils infiltrating into the skin of patients with dipeptidyl peptidase⁃4 inhibitor⁃related bullous pemphigoid［J］. J Dermatol, 2018,45（5）:596⁃599. doi: 10.1111/1346⁃8138.14245.
［17］	Schmidt E, Spindler V, Eming R, et al. Meeting report of the pathogenesis of pemphigus and pemphigoid meeting in munich, september 2016［J］. J Invest Dermatol, 2017,137（6）:1199⁃1203. doi: 10.1016/j.jid.2017.01.028.
［18］	Nader MA. Inhibition of airway inflammation and remodeling by sitagliptin in murine chronic asthma［J］. Int Immunopharmacol, 2015,29（2）:761⁃769. doi: 10.1016/j.intimp.2015.08.043.
［19］	Onprasert W, Chanprapaph K. Lichen planus pemphigoides induced by enalapril: a case report and a review of literature［J］. Case Rep Dermatol, 2017,9（3）:217⁃224. doi: 10.1159/000481449.
［20］	Warshafsky C, Tron VA, Robertson D, et al. Pemphigoid gestationis: a case presentation［J］. J Cutan Med Surg, 2018,22（4）:435⁃438. doi: 10.1177/1203475418760459.
［21］	Al Saif F, Jouen F, Hebert V, et al. Sensitivity and specificity of BP180 NC16A enzyme⁃linked immunosorbent assay for the diagnosis of pemphigoid gestationis［J］. J Am Acad Dermatol, 2017,76（3）:560⁃562. doi: 10.1016/j.jaad.2016.09.030.
［22］	Kanwar AJ. Pemphigoid gestationis［J］. Br J Dermatol, 2015,172（1）:6⁃7. doi: 10.1111/bjd.13457.
［23］	张江安, 于建斌. 妊娠类天疱疮的研究进展［J］. 中国医学文摘（皮肤科学）, 2016,33（5）:609⁃613.
［24］	Toyonaga E, Nishie W, Izumi K, et al. C⁃terminal processing of collagen XVII induces neoepitopes for linear IgA dermatosis autoantibodies［J］. J Invest Dermatol, 2017,137（12）:2552⁃2559. doi: 10.1016/j.jid.2017.07.831.
［25］	Fernandes KA, Galvis KH, Gomes AC, et al. Linear IgA and IgG bullous dermatosis［J］. An Bras Dermatol, 2016,91（5 suppl 1）:32⁃34. doi: 10.1590/abd1806⁃4841.20164630.
［26］	Yamauchi T, Matsushita S, Hashimoto T, et al. Major cleavage⁃dependent epitopes for linear IgA bullous dermatosis are formed at the boundary between the non⁃collagenous 16A and collagenous 15 domains of BP180［J］. J Dermatol Sci, 2014,76（1）:25⁃33. doi: 10.1016/j.jdermsci.2014.07.008.
［27］	Kromminga A, Scheckenbach C, Georgi M, et al. Patients with bullous pemphigoid and linear IgA disease show a dual IgA and IgG autoimmune response to BP180［J］. J Autoimmun, 2000,15（3）:293⁃300. doi: 10.1006/jaut.2000.0437.
［28］	Pas HH, Kloosterhuis GJ, Heeres K, et al. Bullous pemphigoid and linear IgA dermatosis sera recognize a similar 120⁃kDa keratinocyte collagenous glycoprotein with antigenic cross⁃reactivity to BP180［J］. J Invest Dermatol, 1997,108（4）:423⁃429.
［29］	Ohata C, Ishii N, Koga H, et al. A clinical and serological study of linear IgA bullous dermatosis without linear immunoglobulin deposition other than IgA at the basement membrane zone using direct immunofluorescence［J］. Br J Dermatol, 2017,177（1）:152⁃157. doi: 10.1111/bjd.15232.
［30］	Yasukochi A, Teye K, Ishii N, et al. Clinical and immunological studies of 332 Japanese patients tentatively diagnosed as anti⁃BP180⁃type nucous nembrane pemphigoid: a Novel BP180 C⁃terminal domain enzyme⁃linked immunosorbent assay［J］. Acta Derm Venereol, 2016,96（6）:762⁃767. doi: 10.2340/00015555⁃2407.
［31］	Murrell DF, Marinovic B, Caux F, Definitions and outcome measures for mucous membrane pemphigoid: recommendations of an international panel of experts［J］. J Am Acad Dermatol, 2015,72（1）:168⁃174. doi: 10.1016/j.jaad.2014.08.024.
［32］	Chan LS, Ahmed AR, Anhalt GJ, et al. The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators［J］. Arch Dermatol, 2002,138（3）:370⁃379.

[1]	周彤耿松梅. 生物制剂在大疱性类天疱疮治疗中的应用[J]. 中华皮肤科杂志, 2023, 56(8): 789-793.
[2]	闪莹常晓彤左亚刚. 自身免疫性疱病的表位扩展现象[J]. 中华皮肤科杂志, 2023, 56(7): 702-705.
[3]	焦晓燕尹光文李冬芹阴亚坤蔡丙杰方慧. 伴脑卒中的大疱性类天疱疮74例临床分析[J]. 中华皮肤科杂志, 2023, 56(4): 330-334.
[4]	万立胡彬罗红玉方美珍韩丽娟陈强周小勇陈柳青陈金波. 天疱疮或大疱性类天疱疮合并单纯疱疹病毒感染8例临床特征及治疗分析[J]. 中华皮肤科杂志, 2023, 56(3): 229-233.
[5]	任伟琦邹雅茹潘敏. 大疱性类天疱疮患者继发感染危险因素的研究进展[J]. 中华皮肤科杂志, 2023, 0(2): 20220694-e20220694.
[6]	王媛李志量李锁荆可孙超梁桂熔张寒梅冯素英. 抗p200类天疱疮7例临床及免疫血清学特征分析[J]. 中华皮肤科杂志, 2022, 55(7): 557-561.
[7]	赵柳琦陈妍陈丹阳樊碧娆王瑞尚盼盼陈喜雪朱学骏王明悦. 【开放获取】度普利尤单抗治疗大疱性类天疱疮21例的疗效及安全性回顾分析[J]. 中华皮肤科杂志, 2022, 55(6): 480-485.
[8]	闪莹左亚刚. 自身免疫性疱病与银屑病的相关性[J]. 中华皮肤科杂志, 2022, 55(5): 452-455.
[9]	李锁向睿宇李志量荆可王媛张寒梅冯素英. 盐裂皮肤间接免疫荧光技术在大疱性类天疱疮诊断中的价值评估[J]. 中华皮肤科杂志, 2022, 55(3): 235-237.
[10]	李浩, 王俐韩宪伟孙彤苏芳孙晓冬韩莹杨国玲刘晓明王凯波 . 糖尿病患者服用二肽基肽酶Ⅳ抑制剂后发生大疱性类天疱疮32例临床特征分析[J]. 中华皮肤科杂志, 2022, 55(3): 213-218.
[11]	胡枫, 王向东, 夏云, 周小勇, 陈柳青. 国内首报落叶型天疱疮转变为大疱性类天疱疮1例[J]. 中华皮肤科杂志, 2022, 55(2): 156-158.
[12]	赵文玲, 杨语嫣, 李丽, 晋红中. 大疱性类天疱疮合并其他免疫性疾病研究进展[J]. 中华皮肤科杂志, 2022, 55(2): 177-181.
[13]	闪莹常晓彤左亚刚. 非大疱性类天疱疮[J]. 中华皮肤科杂志, 2022, 55(10): 922-924.
[14]	凯丽比努尔·阿卜力克木梁俊琴. 大疱性类天疱疮瘙痒相关机制的研究进展[J]. 中华皮肤科杂志, 2022, 55(10): 919-921.
[15]	王媛余美文向睿宇李锁李志量荆可张寒梅冯素英. 盐裂皮肤-间接免疫荧光方法优化及在大疱性类天疱疮抗体检测中的应用[J]. 中华皮肤科杂志, 2022, 55(1): 12-15.

BP180相关自身免疫性水疱病的研究进展

BP180-related autoimmune blistering diseases

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 32

相关文章 15

Metrics

本文评价

推荐阅读 10