中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (7): 702-705.doi: 10.35541/cjd.20201019

• 综述 • 上一篇    

自身免疫性疱病的表位扩展现象

闪莹1,2    常晓彤   左亚刚1   

  1. 1中国医学科学院  北京协和医学院北京协和医院皮肤科  协和医学转化中心  国家皮肤与免疫疾病临床医学研究中心,北京  100730;2河北北方学院,张家口  075000
  • 收稿日期:2020-10-16 修回日期:2021-01-27 发布日期:2023-07-04
  • 通讯作者: 左亚刚 E-mail:zuoyagang@263.net
  • 基金资助:
    国家自然科学基金(81972944);北京市自然科学基金(7192166)

Epitope spreading in autoimmune bullous diseases

Shan Ying1,2, Chang Xiaotong2, Zuo Yagang1   

  1. 1Department of Dermatology, National Clinical Research Center for Skin and Immune Diseases, Translational Medicine Center of Peking Union Medical College Hospital, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China; 2Hebei North University, Zhangjiakou 075000, China
  • Received:2020-10-16 Revised:2021-01-27 Published:2023-07-04
  • Contact: Zuo Yagang E-mail:zuoyagang@263.net
  • Supported by:
    National Natural Science Foundation of China (81972944); Beijing Municipal Natural Science Foundation (7192166)

摘要: 【摘要】 表位扩展常发生在自身免疫性疱病患者中,该类患者由于表位扩展使得更多的抗原表位暴露,引起原疾病加重、转化或并发其他疾病。随着表位扩展的免疫学证据日益增加,越来越多的学者认识到表位扩展在疾病发展的过程中发挥重要作用。本文从不同类型类天疱疮、不同类型天疱疮、天疱疮与类天疱疮、自身免疫性疱病与其他皮肤病的并发或转化四个方面,介绍自身免疫性疱病中的表位扩展现象。

关键词: 类天疱疮, 大疱性, 天疱疮, 表位, 自身免疫性疱病, 表位扩展, 银屑病

Abstract: 【Abstract】 Epitope spreading often occurs in patients with autoimmune bullous diseases (ABDs), resulting in exposure of more antigenic epitopes, aggravation or transformation of pre-existing diseases, or concurrence of other diseases. With the increase in the immunological evidence for epitope spreading, more and more scholars have realized that epitope spreading plays an important role in the development of ABDs. This review introduces the phenomenon of epitope spreading in ABDs from 4 aspects, including the concurrence or transformation between different types of pemphigoid, different types of pemphigus, pemphigus and pemphigoid, as well as between ABDs and other skin diseases.

Key words: Pemphigoid, bullous, Pemphigus, Epitopes, Autoimmune bullous diseases, Epitope spreading, psoriasis

引用本文

闪莹 常晓彤 左亚刚. 自身免疫性疱病的表位扩展现象[J]. 中华皮肤科杂志, 2023,56(7):702-705. doi:10.35541/cjd.20201019

Shan Ying, Chang Xiaotong, Zuo Yagang. Epitope spreading in autoimmune bullous diseases[J]. Chinese Journal of Dermatology, 2023, 56(7): 702-705.doi:10.35541/cjd.20201019