中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (4): 365-368.doi: 10.35541/cjd.20200947

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过氧化物酶体增殖物激活受体γ对皮肤生理功能和病理过程的影响

连盼盼1    刘军2    苏忠兰3    王宏伟1   

  1. 1南京大学医学院  生命分析化学国家重点实验室和江苏省分子医学重点实验室  210093;2南京大学医学院附属鼓楼医院皮肤科  210093;3南京医科大学第一附属医院皮肤科  210029
  • 收稿日期:2020-09-25 修回日期:2021-04-06 发布日期:2023-03-31
  • 通讯作者: 王宏伟;苏忠兰 E-mail:hwang@nju.edu.cn; suzhonglan@jsph.org.cn
  • 基金资助:
    国家自然科学基金(81773326);江苏省自然科学基金(BE2019676、BK20171117);南京市医学科技发展项目(YKK17081)

Effect of peroxisome proliferator-activated receptor γ on skin physiological and pathological processes

Lian Panpan1, Liu Jun2, Su Zhonglan3, Wang Hongwei1   

  1. 1Medical School of Nanjing University, State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Molecular Medicine, Nanjing 210093, China; 2Department of Dermatology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210093, China; 3Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2020-09-25 Revised:2021-04-06 Published:2023-03-31
  • Contact: Wang Hongwei; Su Zhonglan E-mail:hwang@nju.edu.cn; suzhonglan@jsph.org.cn
  • Supported by:
    National Natural Science Foundation of China (81773326); Natural Science Foundation of Jiangsu Province (BE2019676, BK20171117); Nanjing Medical Science and Technology Development Projects (YKK17081)

摘要: 【摘要】 过氧化物酶体增殖物激活受体(PPAR)广泛参与机体的脂质代谢、糖代谢、细胞生长分化以及炎症发生等过程。PPARγ激动剂可抑制皮肤炎症反应,保护表皮屏障功能,修复损伤。本文总结PPARγ在皮肤生物学中的不同作用,讨论其在银屑病和皮肤肿瘤等疾病中的作用。

关键词: 过氧化物酶体增殖物激活受体, 炎症, 创伤和损伤, 皮肤衰老, 皮肤肿瘤, 银屑病

Abstract: 【Abstract】 Peroxisome proliferator-activated receptors (PPARs) are widely involved in lipid metabolism, glucose metabolism, cell growth and differentiation, and inflammation in the human body. PPARγ agonists can inhibit skin inflammatory response, protect epidermal barrier function, and repair skin injury. This review summarizes various roles of PPARγ in skin biology, and discusses its function in skin diseases, such as psoriasis and skin tumors.

Key words: Peroxisome proliferator-activated receptors, Inflammation, Wounds and injuries, Skin aging, Skin neoplasms, Psoriasis

引用本文

连盼盼 刘军 苏忠兰 王宏伟. 过氧化物酶体增殖物激活受体γ对皮肤生理功能和病理过程的影响[J]. 中华皮肤科杂志, 2023,56(4):365-368. doi:10.35541/cjd.20200947

Lian Panpan, Liu Jun, Su Zhonglan, Wang Hongwei. Effect of peroxisome proliferator-activated receptor γ on skin physiological and pathological processes[J]. Chinese Journal of Dermatology, 2023, 56(4): 365-368.doi:10.35541/cjd.20200947