胶原蛋白肽抗皮肤自然老化作用机制与临床研究进展

doi:10.35541/cjd.20220076

中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (5): 455-458.doi: 10.35541/cjd.20220076

胶原蛋白肽抗皮肤自然老化作用机制与临床研究进展

刘璐^1，2 尹翠元^1，2 胡红忠³ 何琳琳^1，2，4

¹陕西理工大学生物科学与工程学院，汉中 723001；²陕西理工大学维生素D生理与应用研究所，汉中 723001；³汉中天泽嘉源农林科技有限公司，汉中 723001；⁴陕西理工大学秦巴生物资源与生态环境省部共建国家重点实验室（培育），汉中 723001

收稿日期:2022-01-29 修回日期:2022-10-09 发布日期:2023-05-04
通讯作者: 何琳琳 E-mail:helinlin312@163.com
作者简介:作者毕业，希望2023年5或6月见刊
基金资助:
陕西省自然科学基础研究计划项目（2018JM3033）；陕西省“三秦学者”创新团队支持计划项目（陕组通字［2018］34号）；大鲵皮胶原蛋白肽横向项目（H20220046）

Collagen peptide against chronological skin aging: mechanisms of action and related clinical studies

Liu Lu^1,2, Yin Cuiyuan^1,2, Hu Hongzhong³, He Linlin^1,2,4

¹School of Biological Sciences and Engineering, Shaanxi University of Technology, Hanzhong 723001, Shaanxi, China; ²China Institute of Vitamin D Physiology and Applications, Shaanxi University of Technology, Hanzhong 723001, Shaanxi, China; ³Hanzhong Tianze Jiayuan Agriculture and Forestry Technology Co. LTD, Hanzhong 723001, Shaanxi, China; ⁴China State Key Laboratory of Qinba Biological Resources and Ecological Environment （cultivated）, Shaanxi University of Technology, Hanzhong 723001, Shaanxi, China

Received:2022-01-29 Revised:2022-10-09 Published:2023-05-04
Contact: He Linlin E-mail:helinlin312@163.com
Supported by:
Natural Science Basic Research Program of Shaanxi Province （2018JM3033）; Innovation Team Support Plan of Shaanxi "Sanqin Scholars" （Shaanxi Group Tongzi ［2018］34）; Horizontal Project on the Collagen Peptide of Giant Salamander Skin （H20220046）

摘要/Abstract

摘要： 【摘要】近年来胶原蛋白肽（CP）成为延缓皮肤自然老化的研究热点。动物实验证明，CP可通过促进胶原蛋白合成、抑制胶原蛋白降解和提高抗氧化酶活性修复自然老化皮肤。细胞实验证明，CP可通过刺激核因子κB信号通路和转化生长因子β/Smad信号通路促进成纤维细胞增殖和胶原蛋白、弹性蛋白合成。临床研究表明，长期口服补充CP或CP联合其他具有抗氧化活性物质可改善皮肤含水量并降低皮肤经皮水分散失，改善皮肤皱纹和弹性，还可改善皮肤胶原纤维结构、真皮和表皮质量及面部皮肤的整体状况。本文对皮肤自然老化机制和近年来CP修复自然老化皮肤的作用机制研究进行综述，以期为临床进一步研究并应用CP修复自然老化皮肤提供理论依据。

关键词: 皮肤衰老, 动物实验, 细胞实验, 胶原蛋白肽, 皮肤自然老化, 临床研究

Abstract: 【Abstract】 In recent years, collagen peptide （CP） has become a research hotspot in delaying chronological skin aging. Animal experiments have shown that CP can repair chronologically aged animal skin by promoting collagen synthesis, inhibiting collagen degradation, and increasing antioxidant enzyme activity. Cell experiments showed that CP can promote proliferation of fibroblasts and synthesis of collagen and elastin by stimulating nuclear factor-κB signaling pathway and transforming growth factor-β/drosophila mothers against decapentaplegic signaling pathway. Clinical studies have demonstrated that long-term oral supplement with CP or CP in combination with other antioxidant active substances can increase the skin moisture content and reduce transepidermal water loss, improve skin wrinkles and elasticity, as well as improve the skin collagen fiber structure, dermal and epidermal quality and the overall condition of facial skin. This review summarizes recent studies on mechanisms underlying chronological skin aging and mechanisms of action of CP in repairing chronologically aged skin, in order to provide a theoretical basis for further clinical research into and application of CP in repairing chronologically aged skin.

Key words: Skin aging, Animal experimentation, Cell experiments, Collagen peptide, Chronological skin aging, Clinical research

刘璐, 尹翠元, 胡红忠何琳琳, . 胶原蛋白肽抗皮肤自然老化作用机制与临床研究进展[J]. 中华皮肤科杂志, 2023,56(5):455-458. doi:10.35541/cjd.20220076

Liu Lu, Yin Cuiyuan, Hu Hongzhong, He Linlin, . Collagen peptide against chronological skin aging: mechanisms of action and related clinical studies[J]. Chinese Journal of Dermatology, 2023, 56(5): 455-458.doi:10.35541/cjd.20220076

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胶原蛋白肽抗皮肤自然老化作用机制与临床研究进展

Collagen peptide against chronological skin aging: mechanisms of action and related clinical studies

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