细胞老化介导皮肤衰老的研究进展

doi:10.3760/cma.j.issn.0412-4030.2019.03.015

中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (3): 211-214.doi: 10.3760/cma.j.issn.0412-4030.2019.03.015

细胞老化介导皮肤衰老的研究进展

刘文杰姜敏项蕾红

复旦大学附属华山医院皮肤科上海市皮肤病研究所 200040

收稿日期:2018-03-01 修回日期:2018-07-25 发布日期:2019-03-04
通讯作者: 姜敏；项蕾红 E-mail:dermjm@126.com；Flora_xiang@vip.163.com
基金资助:
国家自然科学基金（81502742、81472901）；中华医学会-欧莱雅中国人健康皮肤研究项目（S2017140920）

Cellular senescence-mediated skin aging

Liu Wenjie, Jiang Min, Xiang Leihong

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology, Shanghai 200040, China

Received:2018-03-01 Revised:2018-07-25 Published:2019-03-04
Contact: Jiang Min；Xiang Leihong E-mail:dermjm@126.com；Flora_xiang@vip.163.com
Supported by:
National Natural Science Foundation of China（81502742, 81472901）; Chinese Medical Association ? L′OREAL Chinese Healthy Skin Research Project （S2017140920）

摘要/Abstract

摘要： 【摘要】衰老是年龄相关的机体退行性变，皮肤改变是其最直观的表现之一。细胞老化源于细胞周期的持久性阻滞，它既是衰老的重要标志，也是衰老发生发展的重要机制。随着皮肤的衰老，在表皮和真皮中老化细胞均逐渐累积并进一步加剧衰老，而清除老化细胞则可使皮肤年轻化。细胞老化参与衰老进程可能与激活DNA损伤反应通路、上调阻滞细胞周期的调节蛋白、分泌衰老相关表型增多等机制有关。干预细胞老化有望在将来成为临床抗衰老的新思路和新手段。

关键词: 皮肤衰老, 细胞衰老, 衰老相关分泌表型

Abstract: 【Abstract】 Aging is age-related degeneration of the whole body, and skin aging is one of the most visualized changes in aging. Cellular senescence is a stress response to stable cell cycle arrest, and it is both the hallmark of aging and the important mechanism of the occurrence and development of aging. With the development of skin aging, senescent cells gradually accumulate in both the epidermis and dermis, and further exacerbate aging. Thus, when these senescent cells are eliminated, the aging skin seems to be rejuvenated. Cellular senescence is involved in the process of skin aging, which may be related to activation of DNA damage response pathway, up-regulation of regulatory proteins blocking cell cycle, and increase of senescence-associated secretory phenotypes. Cellular senescence is expected to be a novel target for preventing skin aging in the future.

Key words: Skin aging, Cell aging, Senescence?associated secretory phenotype

刘文杰姜敏项蕾红. 细胞老化介导皮肤衰老的研究进展[J]. 中华皮肤科杂志, 2019,52(3):211-214. doi:10.3760/cma.j.issn.0412-4030.2019.03.015

Liu Wenjie, Jiang Min, Xiang Leihong. Cellular senescence-mediated skin aging[J]. Chinese Journal of Dermatology, 2019, 52(3): 211-214.doi:10.3760/cma.j.issn.0412-4030.2019.03.015

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细胞老化介导皮肤衰老的研究进展

Cellular senescence-mediated skin aging

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