中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (10): 922-924.doi: 10.35541/cjd.20200493

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非大疱性类天疱疮

闪莹1，2    常晓彤2    左亚刚1   

  1. 1中国医学科学院、北京协和医学院北京协和医院皮肤科  协和医学转化中心  国家皮肤与免疫疾病临床医学研究中心，北京  100730；2河北北方学院，张家口  075000
  • 收稿日期:2020-05-20 修回日期:2021-01-11 发布日期:2022-10-08
  • 通讯作者: 左亚刚 E-mail:zuoyagang@263.net
  • 基金资助:
    国家自然科学基金（81972944）；北京市自然科学基金（7192166）

Nonbullous pemphigoid

Shan Ying1,2, Chang Xiaotong2, Zuo Yagang1   

  1. 1Department of Dermatology, National Clinical Research Center for Skin and Immune Diseases, Translational Medicine Center of Peking Union Medical College Hospital, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China; 2Hebei North University, Zhangjiakou 075000, Hebei, China
  • Received:2020-05-20 Revised:2021-01-11 Published:2022-10-08
  • Contact: Zuo Yagang E-mail:zuoyagang@263.net
  • Supported by:
    National Natural Science Foundation of China （81972944）; Natural Science Foundation of Beijing Municipality （7192166）

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摘要： 【摘要】 非大疱性类天疱疮与大疱性类天疱疮相关，临床表现多样，多数伴有瘙痒，缺乏大疱性类天疱疮的紧张性水疱或大疱的典型临床表现，误诊率高。组织病理缺乏特异性，需要依靠直接免疫荧光、间接免疫荧光或盐裂间接免疫荧光明确诊断。部分无疱性类天疱疮会发展为大疱性类天疱疮，预后较大疱性类天疱疮好，但由于易被延迟诊断，使得控制症状的药物用量大，药物不良反应多。

关键词: 类天疱疮, 大疱性, 荧光抗体技术, 非大疱性类天疱疮, 前驱性大疱性类天疱疮

Abstract: 【Abstract】 Nonbullous pemphigoid （NBP）, which is related to bullous pemphigoid, has various clinical manifestations, and is frequently accompanied by itching. Typical clinical manifestations of bullous pemphigoid （BP）, such as tense blisters or bullae, are absent in NBP cases. It is easy to misdiagnose. Histopathological findings are not specific, so diagnosis should be confirmed by direct immunofluorescence, indirect immunofluorescence or salt-split indirect immunofluorescence. NBP may develop into BP in some cases, and the prognosis of NBP is better than that of BP. However, delayed diagnosis usually leads to a relatively high dosage of drugs for disease control, and a high rate of adverse reactions.

Key words: Pemphigoid, bullous, Fluorescent antibody technique, Nonbullous pemphigoid, Prodromal pemphigoid