中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (10): 919-921.doi: 10.35541/cjd.20210448

• 综述 • 上一篇    下一篇

大疱性类天疱疮瘙痒相关机制的研究进展

凯丽比努尔·阿卜力克木1    梁俊琴2   

  1. 1新疆医科大学研究生学院,乌鲁木齐  830054;2新疆维吾尔自治区人民医院皮肤性病科  新疆皮肤病临床医学研究中心  新疆皮肤病研究重点实验室(XJYS1707),乌鲁木齐  830002
  • 收稿日期:2021-06-11 修回日期:2022-03-08 发布日期:2022-10-08
  • 通讯作者: 梁俊琴 E-mail:zyeemail@163.com
  • 基金资助:
    国家科学自然基金(81960564)

Mechanisms of pruritus in bullous pemphigoid

Kailibinuer·Abulikemu1, Liang Junqin2   

  1. 1Postgraduate School of Xinjiang Medical University, Urumqi 830054, China; 2Department of Dermatology, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Key Laboratory of Dermatology Research(XJYS1707), Urumqi 830002, China
  • Received:2021-06-11 Revised:2022-03-08 Published:2022-10-08
  • Contact: Liang Junqin E-mail:zyeemail@163.com
  • Supported by:
    National Natural Science Foundation of China(81960564)

摘要: 【摘要】 瘙痒是大疱性类天疱疮(BP)典型临床表现之一。近年来,研究人员逐渐认识到非组胺依赖性瘙痒途径在BP中发挥重要作用。嗜酸性粒细胞、嗜碱性粒细胞、白细胞介素31(IL-31)、IL-4、IL-13、胸腺基质淋巴细胞生成素、骨膜蛋白、P物质等均与BP瘙痒的发生密切相关。本文主要综述BP瘙痒相关机制的研究进展。

关键词: 类天疱疮, 大疱性, 瘙痒症, 白细胞介素4, 嗜酸性粒细胞, 嗜碱性粒细胞, 白细胞介素31

Abstract: 【Abstract】 Pruritus is one of the typical clinical manifestations of bullous pemphigoid (BP). In recent years, researchers have gradually recognized that the histamine-independent itch pathway plays an important role in BP. Eosinophils, basophils, interleukin (IL)-31, IL-4, IL-13, thymic stromal lymphopoietin, periostin and substance P are all closely related to the occurrence of pruritus in BP. This review mainly elaborates research progress in mechanisms related to pruritus in BP.

Key words: Pemphigoid, bullous, Pruritus, Interleukin-4, Eosinophils, Basophils, Interleukin-31