中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (2): 177-181.doi: 10.35541/cjd.20200014

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大疱性类天疱疮合并其他免疫性疾病研究进展

赵文玲    杨语嫣    李丽    晋红中   

  1. 中国医学科学院  北京协和医学院北京协和医院皮肤科,北京  100730
    赵文玲现在北京市顺义区妇幼保健院皮肤科  北京儿童医院顺义妇儿医院,北京  101300

  • 收稿日期:2020-01-06 修回日期:2020-08-11 发布日期:2022-01-27
  • 通讯作者: 李丽 E-mail:lilipumch2007@sina.com
  • 基金资助:
    国家重点研发计划项目(2016YFC0901500);国家自然科学基金(81972945);北京协和医学院教育教学改革项目(2016zlgc0106);北京市顺义区卫生健康发展科研专项(Wsjkfzkyzx-2019-y-07)

Bullous pemphigoid and its immune-mediated comorbidities

Zhao Wenling, Yang Yuyan, Li Li, Jin Hongzhong   

  1. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
  • Received:2020-01-06 Revised:2020-08-11 Published:2022-01-27
  • Contact: Li Li E-mail:lilipumch2007@sina.com
  • Supported by:
    National Key Research and Development Program of China (2016YFC0901500); National Natural Science Foundation of China (81972945); Education Reform Projects of Peking Union Medical College (2016zlgc0106); Funds of Shunyi District for Health Improvement and Research(Wsjkfzkyzx-2019-y-07)

摘要: 【摘要】 大疱性类天疱疮可合并多种免疫性疾病,如免疫性皮肤病(银屑病、白癜风、斑秃及多种其他免疫性疱病)、消化系统免疫性疾病(炎症性肠病、原发性胆汁性肝硬化)、自身免疫性甲状腺疾病、风湿免疫病(类风湿性关节炎、皮肌炎、硬皮病及系统性红斑狼疮)、泌尿系统免疫性肾脏病(免疫性肾病、肾移植排斥)及A型获得性血友病等,明显影响了患者的生活质量和治疗方案。该文阐述目前报道的大疱性类天疱疮合并的免疫性疾病及其机制。

关键词: 类天疱疮, 大疱性, 免疫系统疾病, 交叉反应, 表位扩展, 多发性自身免疫综合征

Abstract: 【Abstract】 Bullous pemphigoid (BP) can be comorbid with a variety of immune diseases, such as immune skin diseases (psoriasis, vitiligo, alopecia areata and various other immune bullous diseases), immune diseases of the digestive system (inflammatory bowel disease, primary biliary cirrhosis), autoimmune thyroid diseases, autoimmune rheumatic diseases (rheumatoid arthritis, dermatomyositis, scleroderma and systemic lupus erythematosus), immune renal diseases (immune nephropathy, renal allograft rejection) and acquired hemophilia A. The above comorbidities markedly affect the quality of life of and treatment options for patients. This review elaborates currently reported immune diseases associated with BP and their concomitant mechanisms.

Key words: Pemphigoid, bullous, Immune system diseases, Cross reactions, Epitope spreading, Multiple autoimmune syndrome