中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (2): 172-176.doi: 10.35541/cjd.20201076

• 专家笔谈 • 上一篇    下一篇

从外伤后细菌性致死性肉芽肿到巴拉姆希阿米巴感染：20年研究体会

王雷    高天文   

  1. 第四军医大学西京皮肤医院，西安  710032
  • 收稿日期:2020-11-09 修回日期:2021-08-19 发布日期:2022-01-27
  • 通讯作者: 高天文 E-mail:gaotw75401@163.com
  • 基金资助:
    国家自然科学基金（30271196、81371752、31000073、81872518）

From fatal bacterial granuloma after trauma to Balamuthia mandrillaris infection: clinical experience over 20 years

Wang Lei, Gao Tianwen   

  1. Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi′an 710032, China
  • Received:2020-11-09 Revised:2021-08-19 Published:2022-01-27
  • Contact: Tianwen Gao E-mail:gaotw75401@163.com
  • Supported by:
    National Natural Science Foundation of China（30271196、81371752、31000073、81872518）

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摘要： 【摘要】 1960—1990年间，一些中国皮肤科医师注意到少数临床表现为面部皮肤肉芽肿性炎症的患者最终死于脑炎。2001年高天文医师总结了此类患者的临床和病理特点，将其命名为外伤后细菌性致死性肉芽肿，当时初步认为可能由痤疮丙酸杆菌感染所致。2018年证实该病为皮肤和脑组织巴拉姆希阿米巴感染。本文总结中国皮肤科医师对巴拉姆希阿米巴感染的研究历程及其临床、病理特点和治疗方法。

关键词: 阿米巴病, 狒狒巴拉姆希阿米巴, 脑炎, 肉芽肿

Abstract: 【Abstract】 From 1960 to 1990, some Chinese dermatologists noticed that a small number of patients presenting with granulomatous inflammation on the face eventually died of encephalitis. In 2001, Dr. Tianwen Gao summarized clinical and pathological characteristics of these patients and proposed the disease name "fatal bacterial granuloma after trauma", and Propionibacterium acnes was assumed to be the most probable pathogen at that time. In 2018, the disease was confirmed to be Balamuthia mandrillaris infection involving the skin and brain tissues. This review summarized the history of research on Balamuthia mandrillaris infection in China, as well as its clinical, pathological characteristics and treatment methods.

Key words: Amebiasis, Balamuthia mandrillaris, Encephalitis, Granuloma