中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (9): 764-767.doi: 10.35541/cjd.20190335

• 综述 • 上一篇    

光疗在皮肤T细胞淋巴瘤中的应用进展

周栩悦    栾超    陈崑   

  1. 中国医学科学院  北京协和医学院  皮肤病医院理疗科，南京  210042
  • 收稿日期:2019-02-25 修回日期:2019-09-09 发布日期:2020-08-31
  • 通讯作者: 陈崑 E-mail:kunchen181@aliyun.com
  • 基金资助:
    国家自然科学基金（81872545、81703152）；江苏省自然科学基金（BK20170161）；北京协和医学院协和青年科研基金（2017310032）

Application of phototherapy in cutaneous T-cell lymphomas

Zhou Xuyue, Luan Chao, Chen Kun   

  1. Department of Physical Therapy, Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2019-02-25 Revised:2019-09-09 Published:2020-08-31
  • Contact: Chen Kun E-mail:kunchen181@aliyun.com
  • Supported by:
    National Natural Science Foundation of China（81872545, 81703152）; Natural Science Foundation of Jiangsu Province of China （BK20170161）; PUMC Youth Fund （2017310032）

PDF

38

PDF (Mobile)

0

摘要： 【摘要】 皮肤T细胞淋巴瘤（CTCL）是T细胞来源的恶性肿瘤，目前针对CTCL的治疗主要为了控制症状及长期缓解，光疗及其联合疗法是重要手段之一。应用于CTCL的光疗方法包括长波紫外线加补骨脂素、窄谱中波紫外线、宽谱中波紫外线、体外光化学疗法、光动力疗法、长波紫外线1、308 nm准分子激光等。光疗效果受多种因素影响，如疾病分期、皮损部位、皮肤光反应类型等。在临床应用中，光疗包括清除、巩固、维持阶段，但维持治疗能否控制复发仍存在争议。了解各种光疗的机制、适应证、临床疗效及不良反应有助于选择最佳治疗方案。

关键词: 淋巴瘤, T细胞, 皮肤, 紫外线疗法, Sézary综合征, 淋巴瘤样丘疹病, 蕈样肉芽肿

Abstract: 【Abstract】 Cutaneous T-cell lymphomas （CTCLs） are malignancies derived from T-cells. The aim of treatment is to control symptoms and achieve long-term remission, and phototherapy and its combined therapy are one of important treatment methods. Phototherapy of CTCLs includes psoralens and ultraviolet A radiation, narrowband ultraviolet B radiation, extracorporeal photochemotherapy, photodynamic therapy, ultraviolet A1 radiation, 308-nm excimer laser and so on. Efficacy of phototherapy is associated with various factors, such as stage of disease, sites of lesions, types of skin photoreaction, etc. In clinical practice, phototherapy involves clearance, consolidation and maintenance phases, but it is still disputed whether maintenance treatment can control the recurrence of CTCLs. Understanding action mechanisms, indications, therapeutic effects and adverse reactions of phototherapy is helpful in selecting the best treatment protocol.

Key words: Lymphoma, T-cell, cutaneous, Ultraviolet therapy, Sezary syndrome, Lymphomatoid papulosis, Mycosis fungoides