中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (9): 759-763.doi: 10.35541/cjd.20190457
孙本森 杜丹 张南 郭玲宏 蒋献
收稿日期:
2019-04-02
修回日期:
2020-01-05
发布日期:
2020-08-31
通讯作者:
蒋献
E-mail:jennyxianj@163.com
Sun Bensen, Du Dan, Zhang Nan, Guo Linghong, Jiang Xian
Received:
2019-04-02
Revised:
2020-01-05
Published:
2020-08-31
Contact:
Jiang Xian
E-mail:jennyxianj@163.com
摘要: 【摘要】 发光二极管(LED)可产生包括蓝光、黄光、红光、红外光等不同波长的光。LED光以其安全、可操控性强、纯色性好、低能量等特点在皮肤科得到广泛应用,如蓝光多用于痤疮治疗,黄光多用于黄褐斑治疗,红光可用于雄激素性脱发的治疗,红外光具有促进皮肤修复的功能等。临床中,多波段联合应用也成为一种趋势,红光与蓝光、红光与黄光、黄光与红外光等组合在痤疮、激光术后修复、皮肤年轻化等方面卓有成效。
孙本森 杜丹 张南 郭玲宏 蒋献. 发光二极管在皮肤科的应用进展[J]. 中华皮肤科杂志, 2020,53(9):759-763. doi:10.35541/cjd.20190457
Sun Bensen, Du Dan, Zhang Nan, Guo Linghong, Jiang Xian. Application of light-emitting diodes in dermatology[J]. Chinese Journal of Dermatology, 2020, 53(9): 759-763.doi:10.35541/cjd.20190457
[1] | Jagdeo J, Austin E, Mamalis A, et al. Light⁃emitting diodes in dermatology: a systematic review of randomized controlled trials[J]. Lasers Surg Med, 2018. doi: 10.1002/lsm.22791. |
[2] | Chen L, Xu Z, Jiang M, et al. Light⁃emitting diode 585 nm photomodulation inhibiting melanin synthesis and inducing autophagy in human melanocytes[J]. J Dermatol Sci, 2018,89(1):11⁃18. doi: 10.1016/j.jdermsci.2017.10.001. |
[3] | Opel DR, Hagstrom E, Pace AK, et al. Light⁃emitting diodes: a brief review and clinical experience[J]. J Clin Aesthet Dermatol, 2015,8(6):36⁃44. |
[4] | Sorbellini E, Rucco M, Rinaldi F. Photodynamic and photobiological effects of light⁃emitting diode (LED) therapy in dermatological disease: an update[J]. Lasers Med Sci, 2018,33(7):1431⁃1439. doi: 10.1007/s10103⁃018⁃2584⁃8. |
[5] | Barolet D. Light⁃emitting diodes (LEDs) in dermatology[J]. Semin Cutan Med Surg, 2008,27(4):227⁃238. doi: 10.1016/j.sder. 2008.08.003. |
[6] | Liebmann J, Born M, Kolb⁃Bachofen V. Blue⁃light irradiation regulates proliferation and differentiation in human skin cells[J]. J Invest Dermatol, 2010,130(1):259⁃269. doi: 10.1038/jid. 2009.194. |
[7] | 郭洪芳, 王慧, 龚黎青. 蓝光照射治疗烧伤创口感染的效果观察[J]. 中国美容整形外科杂志, 2018,29(10):6. doi: 10.3969/j.issn.1673⁃7040.2018.10.016. |
[8] | Zhang Y, Zhu Y, Chen J, et al. Antimicrobial blue light inactivation of Candida albicans: in vitro and in vivo studies[J]. Virulence, 2016,7(5):536⁃545. doi: 10.1080/21505594.2016.115 5015. |
[9] | Dai T, Hamblin MR. Visible blue light is capable of inactivating Candida albicans and other fungal species[J]. Photomed Laser Surg, 2017,35(7):345⁃346. doi: 10.1089/pho.2017.4318. |
[10] | Falcone D, Uzunbajakava NE, van Abeelen F, et al. Effects of blue light on inflammation and skin barrier recovery following acute perturbation. Pilot study results in healthy human subjects[J]. Photodermatol Photoimmunol Photomed, 2018,34(3):184⁃193. doi: 10.1111/phpp.12367. |
[11] | Castellano⁃Pellicena I, Uzunbajakava NE, Mignon C, et al. Does blue light restore human epidermal barrier function via activation of opsin during cutaneous wound healing?[J]. Lasers Surg Med, 2019,51(4):370⁃382. doi: 10.1002/lsm.23015. |
[12] | Keemss K, Pfaff SC, Born M, et al. Prospective, randomized study on the efficacy and safety of local UV⁃free blue light treatment of eczema[J]. Dermatology, 2016,232(4):496⁃502. doi: 10.1159/000448000. |
[13] | Pfaff S, Liebmann J, Born M, et al. Prospective randomized long⁃term study on the efficacy and safety of UV⁃free blue light for treating mild psoriasis vulgaris[J]. Dermatology, 2015,231(1):24⁃34. doi: 10.1159/000430495. |
[14] | Ablon G. Combination 830⁃nm and 633⁃nm light⁃emitting diode phototherapy shows promise in the treatment of recalcitrant psoriasis: preliminary findings[J]. Photomed Laser Surg, 2010,28(1):141⁃146. doi: 10.1089/pho.2009.2484. |
[15] | Ho D, Koo E, Mamalis A, et al. A systematic review of light emitting diode (LED) phototherapy for treatment of psoriasis: an emerging therapeutic modality[J]. J Drugs Dermatol, 2017,16(5):482⁃488. |
[16] | Weiss RA, McDaniel DH, Geronemus RG, et al. Clinical experience with light⁃emitting diode (LED) photomodulation[J]. Dermatol Surg, 2005,31(9 Pt 2):1199⁃1205. doi: 10.1111/j.1524⁃4725.2005.31926. |
[17] | Alster TS, Wanitphakdeedecha R. Improvement of postfractional laser erythema with light⁃emitting diode photomodulation[J]. Dermatol Surg, 2009,35(5):813⁃815. doi: 10.1111/j.1524⁃4725. 2009.01137.x. |
[18] | Khoury JG, Goldman MP. Use of light⁃emitting diode photomodulation to reduce erythema and discomfort after intense pulsed light treatment of photodamage[J]. J Cosmet Dermatol, 2008,7(1):30⁃34. doi: 10.1111/j.1473⁃2165.2008.00358.x. |
[19] | Sadick NS. Handheld LED array device in the treatment of acne vulgaris[J]. J Drugs Dermatol, 2008,7(4):347⁃350. |
[20] | Li Y, Zhang J, Xu Y, et al. The histopathological investigation of red and blue light emitting diode on treating skin wounds in Japanese big⁃ear white rabbit[J]. PLoS One, 2016,11(6):e0157898. doi: 10.1371/journal.pone.0157898. |
[21] | Szezerbaty S, de Oliveira RF, Pires⁃Oliveira D, et al. The effect of low⁃level laser therapy (660 nm) on the gene expression involved in tissue repair[J]. Lasers Med Sci, 2018,33(2):315⁃321. doi: 10.1007/s10103⁃017⁃2375⁃7. |
[22] | Choi SH, Chang SY, Biswas R, et al. Light⁃emitting diode irradiation using 660 nm promotes human fibroblast HSP90 expression and changes cellular activity and morphology[J]. J Biophotonics, 2019,12(9):e201900063. doi: 10.1002/jbio.201900 063. |
[23] | Erdle BJ, Brouxhon S, Kaplan M, et al. Effects of continuous⁃wave (670⁃nm) red light on wound healing[J]. Dermatol Surg, 2008,34(3):320⁃325. doi: 10.1111/j.1524⁃4725.2007.34065.x. |
[24] | Lanzafame RJ, Blanche RR, Bodian AB, et al. The growth of human scalp hair mediated by visible red light laser and LED sources in males[J]. Lasers Surg Med, 2013,45(8):487⁃495. doi: 10.1002/lsm.22173. |
[25] | Lanzafame RJ, Blanche RR, Chiacchierini RP, et al. The growth of human scalp hair in females using visible red light laser and LED sources[J]. Lasers Surg Med, 2014,46(8):601⁃607. doi: 10. 1002/lsm.22277. |
[26] | Darwin E, Heyes A, Hirt PA, et al. Low⁃level laser therapy for the treatment of androgenic alopecia: a review[J]. Lasers Med Sci, 2018,33(2):425⁃434. doi: 10.1007/s10103⁃017⁃2385⁃5. |
[27] | Han L, Liu B, Chen X, et al. Activation of Wnt/β⁃catenin signaling is involved in hair growth⁃promoting effect of 655⁃nm red light and LED in in vitro culture model[J]. Lasers Med Sci, 2018,33(3):637⁃645. doi: 10.1007/s10103⁃018⁃2455⁃3. |
[28] | Park KY, Choi SY, Mun SK, et al. Combined treatment with 578⁃/511⁃nm copper bromide laser and light⁃emitting diodes for post⁃laser pigmentation: a report of two cases[J]. Dermatol Ther, 2014,27(2):121⁃125. doi: 10.1111/dth.12080. |
[29] | Oh CT, Kwon TR, Choi EJ, et al. Inhibitory effect of 660⁃nm LED on melanin synthesis in in vitro and in vivo[J]. Photodermatol Photoimmunol Photomed, 2017,33(1):49⁃57. doi: 10.1111/phpp.12276. |
[30] | Barolet D, Boucher A. LED photoprevention: reduced MED response following multiple LED exposures[J]. Lasers Surg Med, 2008,40(2):106⁃112. doi: 10.1002/lsm.20615. |
[31] | Myakishev⁃Rempel M, Stadler I, Polesskaya O, et al. Red light modulates ultraviolet⁃induced gene expression in the epidermis of hairless mice[J]. Photomed Laser Surg, 2015,33(10):498⁃503. doi: 10.1089/pho.2015.3916. |
[32] | Nussbaum EL, Lilge L, Mazzulli T. Effects of 630⁃, 660⁃, 810⁃, and 905⁃nm laser irradiation delivering radiant exposure of 1⁃50 J/cm2 on three species of bacteria in vitro[J]. J Clin Laser Med Surg, 2002,20(6):325⁃333. doi: 10.1089/104454702320901116. |
[33] | Barolet D, Christiaens F, Hamblin MR. Infrared and skin: friend or foe[J]. J Photochem Photobiol B, 2016,155:78⁃85. doi: 10. 1016/j.jphotobiol.2015.12.014. |
[34] | Holzer AM, Athar M, Elmets CA. The other end of the rainbow: infrared and skin[J]. J Invest Dermatol, 2010,130(6):1496⁃1499. doi: 10.1038/jid.2010.79. |
[35] | Tanaka Y, Matsuo K, Yuzuriha S. Long⁃term histological comparison between near⁃infrared irradiated skin and scar tissues[J]. Clin Cosmet Investig Dermatol, 2010,3:143⁃149. doi: 10.2147/CCID.S15729. |
[36] | Yasunaga Y, Matsuo K, Tanaka Y, et al. Near⁃infrared irradiation increases length of axial pattern flap survival in rats[J]. Eplasty, 2017,17:e26. |
[37] | Choi M, Kim JE, Cho KH, et al. In vivo and in vitro analysis of low level light therapy: a useful therapeutic approach for sensitive skin[J]. Lasers Med Sci, 2013,28(6):1573⁃1579. doi: 10.1007/s10103⁃013⁃1281⁃x. |
[38] | Lee JB, Bae SH, Moon KR, et al. Light⁃emitting diodes downregulate cathelicidin, kallikrein and toll⁃like receptor 2 expressions in keratinocytes and rosacea⁃like mouse skin[J]. Exp Dermatol, 2016,25(12):956⁃961. doi: 10.1111/exd.13133. |
[39] | de Andrade AL, Bossini PS, Parizotto NA. Use of low level laser therapy to control neuropathic pain: a systematic review[J]. J Photochem Photobiol B, 2016,164:36⁃42. doi: 10.1016/j.jphotobiol. 2016.08.025. |
[40] | Yan W, Chow R, Armati PJ. Inhibitory effects of visible 650⁃nm and infrared 808⁃nm laser irradiation on somatosensory and compound muscle action potentials in rat sciatic nerve: implications for laser⁃induced analgesia[J]. J Peripher Nerv Syst, 2011,16(2):130⁃135. doi: 10.1111/j.1529⁃8027.2011.00337. x. |
[41] | Masoumipoor M, Jameie SB, Janzadeh A, et al. Effects of 660⁃ and 980⁃nm low⁃level laser therapy on neuropathic pain relief following chronic constriction injury in rat sciatic nerve[J]. Lasers Med Sci, 2014,29(5):1593⁃1598. doi: 10.1007/s10103⁃014⁃1552⁃1. |
[42] | Barolet D. Dual effect of photobiomodulation on melasma: downregulation of hyperpigmentation and enhanced solar resistance⁃a pilot study[J]. J Clin Aesthet Dermatol, 2018,11(4):28⁃34. |
[43] | Morita A. Current developments in phototherapy for psoriasis[J]. J Dermatol, 2018,45(3):287⁃292. doi: 10.1111/1346⁃8138. 14213. |
[44] | Goldstein NB, Koster MI, Jones KL, et al. Repigmentation of human vitiligo skin by NBUVB is controlled by transcription of GLI1 and activation of the β⁃catenin pathway in the hair follicle bulge stem cells[J]. J Invest Dermatol, 2018,138(3):657⁃668. doi: 10.1016/j.jid.2017.09.040. |
[45] | 贺勤, 宋鹏飞, 陈加媛, 等. 两种308 nm紫外线治疗白癜风的对照研究[J]. 临床皮肤科杂志, 2017,46(12):880⁃882. doi: 10.16761/j.cnki.1000⁃4963.2017.12.018. |
[46] | 刘黎明. 308 nm准分子光和308 nm LZD紫外线治疗白癜风的效果对比观察[J]. 皮肤病与性病, 2019,41(2):227⁃229. doi: 10.3969/j.issn.1002⁃1310.2019.02.036. |
[47] | Alba MN, Gerenutti M, Yoshida VM, et al. Clinical comparison of salicylic acid peel and LED⁃Laser phototherapy for the treatment of Acne vulgaris in teenagers[J]. J Cosmet Laser Ther, 2017,19(1):49⁃53. doi: 10.1080/14764172.2016.1247961. |
[48] | Kwon HH, Lee JB, Yoon JY, et al. The clinical and histological effect of home⁃use, combination blue⁃red LED phototherapy for mild⁃to⁃moderate acne vulgaris in Korean patients: a double⁃blind, randomized controlled trial[J]. Br J Dermatol, 2013,168(5):1088⁃1094. doi: 10.1111/bjd.12186. |
[49] | Kong YL, Tey HL. Treatment of acne vulgaris during pregnancy and lactation[J]. Drugs, 2013,73(8):779⁃787. doi: 10.1007/s40265⁃013⁃0060⁃0. |
[50] | Wanitphakdeedecha R, Iamphonrat T, Phothong W, et al. Local and systemic effects of low⁃level light therapy with light⁃emitting diodes to improve erythema after fractional ablative skin resurfacing: a controlled study[J]. Lasers Med Sci, 2019,34(2):343⁃351. doi: 10.1007/s10103⁃018⁃2599⁃1. |
[51] | Lee SY, Park KH, Choi JW, et al. A prospective, randomized, placebo⁃controlled, double⁃blinded, and split⁃face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings[J]. J Photochem Photobiol B, 2007,88(1):51⁃67. doi: 10.1016/j.jphotobiol.2007.04.008. |
[52] | Wen X, Li Y, Hamblin MR. Photodynamic therapy in dermatology beyond non⁃melanoma cancer: an update[J]. Photodiagnosis Photodyn Ther, 2017,19:140⁃152. doi: 10.1016/j.pdpdt.2017.06.010. |
[53] | Erkiert⁃Polguj A, Halbina A, Polak⁃Pacholczyk I, et al. Light⁃emitting diodes in photodynamic therapy in non⁃melanoma skin cancers⁃⁃own observations and literature review[J]. J Cosmet Laser Ther, 2016,18(2):105⁃110. doi: 10.3109/14764172.2015. 1114635. |
[54] | Cochrane C, Mordon SR, Lesage JC, et al. New design of textile light diffusers for photodynamic therapy[J]. Mater Sci Eng C Mater Biol Appl, 2013,33(3):1170⁃1175. doi: 10.1016/j.msec. 2012.12.007. |
[55] | Attili SK, Lesar A, McNeill A, et al. An open pilot study of ambulatory photodynamic therapy using a wearable low⁃irradiance organic light⁃emitting diode light source in the treatment of nonmelanoma skin cancer[J]. Br J Dermatol, 2009,161(1):170⁃173. doi: 10.1111/j.1365⁃2133.2009.09096.x. |
[56] | Rkein AM, Ozog DM. Photodynamic therapy[J]. Dermatol Clin, 2014,32(3):415⁃425. doi: 10.1016/j.det.2014.03.009. |
[1] | 迪丽达尔·亚森 梅星星 周晖 陈小红 唐旭华. 肺炎支原体诱导的皮疹和黏膜炎8例临床特征及预后分析[J]. 中华皮肤科杂志, 2022, 55(9): 767-771. |
[2] | 魏瑾 臧东杰 曾三武 蒋靖 伦文辉. Dowling-Degos病1家系KRT5基因新突变分析[J]. 中华皮肤科杂志, 2022, 55(8): 703-705. |
[3] | 竞艳 费文敏 李承旭 崔勇. 多磺酸黏多糖乳膏对兔耳增生性瘢痕的抑制作用及机制研究[J]. 中华皮肤科杂志, 2022, 55(8): 720-726. |
[4] | 冯华 高英姝 李清 孙联文. 细胞力学在皮肤科的研究进展[J]. 中华皮肤科杂志, 2022, 55(7): 641-644. |
[5] | 李周娜 金玟言 金哲虎. 超声联合4-羟苯基维胺微泡对瘢痕疙瘩成纤维细胞Ⅰ型胶原蛋白α1链表达的影响[J]. 中华皮肤科杂志, 2022, 55(7): 596-598. |
[6] | 吴淑辉 朱明芳 魏露 张曦 覃秋艳 王畅. 石榴皮多酚对大鼠耳廓痤疮模型mTOR/HIF-1α/RORγt信号通路的影响[J]. 中华皮肤科杂志, 2022, 55(6): 511-516. |
[7] | 中国医师协会皮肤科医师分会自身免疫病专业委员会 . 【开放获取】环孢素治疗免疫相关性皮肤病专家建议[J]. 中华皮肤科杂志, 2022, 55(6): 471-479. |
[8] | 刘乙萱 姜沛彧 刘韵祎 张嘉文 陶梦 李敏 许阳. 玫瑰痤疮神经源性炎症及肉毒毒素治疗相关机制的研究进展[J]. 中华皮肤科杂志, 2022, 55(6): 552-554. |
[9] | 宋晓婷 刘擘 陈玉迪 赵作涛. 玫瑰痤疮的病理生理发病机制研究进展[J]. 中华皮肤科杂志, 2022, 55(5): 446-449. |
[10] | 罗帅寒天 龙海 陆前进, . 2021年系统性红斑狼疮研究新进展[J]. 中华皮肤科杂志, 2022, 55(4): 369-372. |
[11] | 王敏 何萍秀 程丽芳 洪克春 艾勇. 头皮脑(脊)膜错构瘤1例[J]. 中华皮肤科杂志, 2022, 0(3): 20210080-e20210080. |
[12] | 吴淑辉 朱明芳 张曦 杨逸璇 张娟娟. 牛奶对金黄地鼠皮脂腺斑及IGF-1/SREBP-1/ACC-1信号通路的影响[J]. 中华皮肤科杂志, 2022, 55(3): 238-242. |
[13] | 李中明, 许文嵘, 朱麒麟, 朱晶, 李煜乾, 孙杰, 尹莉, 杜旭峰. 瘢痕性女性型脱发1例[J]. 中华皮肤科杂志, 2022, 55(2): 142-145. |
[14] | 孙静 徐英男 林彤 薛劲松. 28例重度玫瑰痤疮眼型眼部损害临床治疗结局分析[J]. 中华皮肤科杂志, 2022, 0(2): 20210755-e20210755. |
[15] | 封梦荻 王文氢. 转录因子和受体调控痤疮发病机制的研究进展[J]. 中华皮肤科杂志, 2022, 0(1): 20210457-e20210457. |
|