Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (12): 1167-1169.doi: 10.35541/cjd.20220088

• Reviews • Previous Articles     Next Articles

Role of epigenetics in the pathogenesis of atopic dermatitis

Song Kuangnan1,2, Zhang Siping2   

  1. 1Wannan Medical College, Wuhu 241002, Anhui, China; 2Department of Dermatology, the First Affiliated Hospital of USTC(Anhui Provincial Hospital), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China
  • Received:2022-02-10 Revised:2022-09-04 Online:2023-12-15 Published:2023-12-05
  • Contact: Zhang Siping
  • Supported by:
    Anhui Provincial Natural Science Foundation(1808085MH259)

Abstract: 【Abstract】 Gene epigenetic modification can turn on and off the program of gene expression without changing the DNA sequence, and the underlying mechanisms mainly include DNA methylation, histone modification and miRNA regulation. A series of studies have shown that epigenetic regulation is involved in the pathogenesis of atopic dermatitis. This review briefly summarizes the role of gene epigenetic modification in the pathogenesis of atopic dermatitis.

Key words: Dermatitis, atopic, Epigenetic modification, Skin barrier, Immune cells