Chinese Journal of Dermatology ›› 2020, Vol. 53 ›› Issue (9): 754-759.doi: 10.35541/cjd.20190312

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Tumor immune microenvironment in cutaneous T-cell lymphoma

Li Fan, Wang Lin   

  1. Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2019-02-18 Revised:2019-12-16 Online:2020-09-15 Published:2020-08-31
  • Contact: Wang Lin
  • Supported by:
    Key Research Projects of the Sichuan Provincial Health and Family Planning Commission (16ZD011)

Abstract: 【Abstract】 Cutaneous T-cell lymphoma (CTCL) is a group of heterogeneous tumors with different clinical manifestations, pathological changes, immunophenotypes and molecular biological characteristics, and its pathogenesis is not completely clear. In recent years, more and more evidence has indicated that the composition and function of tumor immune microenvironment contribute a lot to the development of CTCL. A deep understanding of the composition of the tumor microenvironment in CTCL can help to find more effective anti-tumor immunotherapies, and help clinicians predict the prognosis of the disease more accurately. This review summarizes basic and clinical research progress in CTCL immune microenvironment in recent years.

Key words: Tumor microenvironment, Immunity, Lymphoma, T?cell, cutaneous, Mycosis fungoides