Chinese Journal of Dermatology ›› 2026, Vol. 59 ›› Issue (4): 320-326.doi: 10.35541/cjd.20250171
Previous Articles Next Articles
Society of Aesthetic Dermatology, Chinese Association of Plastics and Aesthetics; Dermatology Committee, Chinese Non-government Medical Institutions Association
Received:2025-04-01
Revised:2025-06-25
Online:2026-04-15
Published:2026-04-03
Contact:
Xiang Leihong
E-mail:flora_xiang@vip.163.com
Society of Aesthetic Dermatology, Chinese Association of Plastics and Aesthetics, Dermatology Committee, Chinese Non-government Medical Institutions Association. Expert recommendations on the application of medical recombinant humanized collagens in facial rejuvenation (2026 edition)[J]. Chinese Journal of Dermatology, 2026, 59(4): 320-326.doi:10.35541/cjd.20250171
| [1] | Shin J, Kwon S, Choi J, et al. Molecular mechanisms of dermal aging and antiaging approaches[J]. Int J Mol Sci, 2019,20(9):2126. DOI: 10.3390/ijms20092126. |
| [2] | Poon F, Kang S, Chien AL. Mechanisms and treatments of photoaging[J]. Photodermatol Photoimmunol Photomed, 2015,31(2):65⁃74. DOI: 10.1111/phpp.12145. |
| [3] | Li L, Ngo HTT, Hwang E, et al. Conditioned medium from human adipose⁃derived mesenchymal stem cell culture prevents UVB⁃induced skin aging in human keratinocytes and dermal fibroblasts[J]. Int J Mol Sci, 2019,21(1):49. DOI: 10.3390/ijms21010049. |
| [4] | Wang J, Qiu H, Xu Y, et al. The biological effect of recombinant humanized collagen on damaged skin induced by UV⁃photoaging: an in vivo study[J]. Bioact Mater, 2022,11:154⁃165. DOI: 10.1016/j.bioactmat.2021.10.004. |
| [5] | Hua C, Zhu Y, Xu W, et al. Characterization by high⁃resolution crystal structure analysis of a triple⁃helix region of human collagen type Ⅲ with potent cell adhesion activity[J]. Biochem Biophys Res Commun, 2019,508(4):1018⁃1023. DOI: 10.1016/j.bbrc.2018.12.018. |
| [6] | Jia Y, Qiu L, Zhang H, et al. Efficacy and safety of typeⅢcollagen lyophilized fibers using mid⁃to⁃deep dermal facial injections for the correction of dynamic facial wrinkles[J]. Aesthetic Plast Surg, 2024,48(13):2500⁃2512. DOI: 10.1007/s00266⁃023⁃03838⁃6. |
| [7] | 曹力登, 邱禾, 刘硕, 等. 微针注射重组Ⅲ型人源化胶原蛋白对皮肤年轻化的效果[J]. 中华医学美学美容杂志, 2022,28(4):300⁃303. DOI: 10.3760/cma.j.issn.1671⁃0290.2022.04.012. |
| [8] | 国家药品监督管理局. YY/T1954—2025 重组胶原蛋白肽图指纹图谱分析[S] . 北京: 国家药品监督管理局, 2025. |
| [9] | 国家药品监督管理局医疗器械标准管理中心. 重组胶原蛋白生物材料命名指导原则[EB/OL]. (2021⁃03⁃15)[2024⁃06⁃05]. https://www.nmpa.gov.cn/xxgk/ggtg/ylqxggtg/ylqxqtggtg/20210315175109170.html. |
| [10] | 国家药品监督管理局. YY/T 1849—2022 重组胶原蛋白[S]. 北京: 国家药品监督管理局, 2022. |
| [11] | 国家药品监督管理局. YY/T 1888—2023 重组人源化胶原蛋白[S]. 北京: 国家药品监督管理局, 2023. |
| [12] | 国家药品监督管理局医疗器械标准管理中心. 《重组胶原蛋白生物材料命名指导原则》解读[EB/OL]. (2023⁃01⁃29)[2024⁃06⁃05]. https://www.nifdc.org.cn/nifdc/bshff/ylqxbzhgl/qxggtzh/ggqt/20230129133404449638.html. |
| [13] | Bai M, Kang N, Xu Y, et al. The influence of tag sequence on recombinant humanized collagen (rhCol) and the evaluation of rhCol on Schwann cell behaviors[J]. Regen Biomater, 2023,10:rbad089. DOI: 10.1093/rb/rbad089. |
| [14] | 于皓玥, 章婧, 蔄茂强, 等. 真皮衰老与成纤维细胞老化关系的研究进展[J]. 皮肤科学通报, 2023,40(5):559⁃563+578. |
| [15] | Baumann L. Collagen⁃containing fillers: alone and in combination[J]. Clin Plast Surg, 2006,33(4):587⁃596. DOI: 10. 1016/j.cps.2006.08.001. |
| [16] | Kuivaniemi H, Tromp G. Type Ⅲ collagen (COL3A1): gene and protein structure, tissue distribution, and associated diseases[J]. Gene, 2019,707:151⁃171. DOI: 10.1016/j.gene.2019.05.003. |
| [17] | 荣艳华, 张国安, 王成, 等. 不同年龄组人正常皮肤Ⅰ型和Ⅲ型胶原含量的比较[J]. 中华烧伤杂志, 2008,(1):3. DOI: 10.3760/cma.j.issn.1009⁃2587.2008.01.016. |
| [18] | Russell⁃Goldman E, Murphy GF. The pathobiology of skin aging: new insights into an old dilemma[J]. Am J Pathol, 2020,190(7):1356⁃1369. DOI: 10.1016/j.ajpath.2020.03.007. |
| [19] | Fisher G, Rittié L. Restoration of the basement membrane after wounding: a hallmark of young human skin altered with aging[J]. J Cell Commun Signal, 2018,12(1):401⁃411. DOI: 10.1007/s12079⁃017⁃0417⁃3. |
| [20] | Langton AK, Halai P, Griffiths CEM, et al. The impact of intrinsic ageing on the protein composition of the dermal⁃epidermal junction[J]. Mech Ageing Dev, 2016,156:14⁃16. DOI: 10.1016/j.mad.2016.03.006. |
| [21] | Liu N, Matsumura H, Kato T, et al. Stem cell competition orchestrates skin homeostasis and ageing[J]. Nature, 2019,568(7752):344⁃350. DOI: 10.1038/s41586⁃019⁃1085⁃7. |
| [22] | You S, Liu S, Dong X, et al. Intravaginal administration of human type Ⅲ collagen⁃derived biomaterial with high cell⁃adhesion activity to treat vaginal atrophy in rats[J]. ACS Biomater Sci Eng, 2020,6(4):1977⁃1988. DOI: 10.1021/acsbiomaterials.9b01649. |
| [23] | You S, Zhu Y, Li H, et al. Recombinant humanized collagen remodels endometrial immune microenvironment of chronic endometritis through macrophage immunomodulation[J]. Regen Biomater, 2023,10:rbad033. DOI: 10.1093/rb/rbad033. |
| [24] | Wang J, Hu H, Wang J, et al. Characterization of recombinant humanized collagen type Ⅲ and its influence on cell behavior and phenotype[J]. J Leather Sci Eng, 2022,4:33.DOI: 10.1186/s42825⁃022⁃00103⁃5. |
| [25] | Humphrey JD, Dufresne ER, Schwartz MA. Mechanotransduction and extracellular matrix homeostasis[J]. Nat Rev Mol Cell Biol, 2014,15(12):802⁃812. DOI: 10.1038/nrm3896. |
| [26] | 严蕾, 杜娟, 余凡, 等. 重组Ⅲ型人源化胶原蛋白水光注射技术的操作规范[J]. 中国医疗美容, 2023,13(3):56⁃60. DOI: 10.19593/j.issn.2095⁃0721.2023.03.009. |
| [27] | 吴艳. 美塑疗法在皮肤美容中应用的专家共识[J]. 中国美容医学, 2020,29(8):44⁃48. DOI: 10.15909/j.cnki.cn61⁃1347/r. 003866. |
| [28] | 中华医学会皮肤性病学分会皮肤激光医疗美容学组, 中华医学会皮肤性病学分会激光技术应用研究中心, 中华医学会医学美学与美容学分会. 微针治疗临床应用中国专家共识(2022版)[J]. 实用皮肤病学杂志, 2022,15(4):193⁃196. DOI: 10.11786/sypfbxzz.1674⁃1293.20220401. |
| [29] | Kim JH, Kwon T, Hong SW, et al. Comparative evaluation of the biodegradability and wrinkle reduction efficacy of human⁃derived collagen filler and hyaluronic acid filler[J]. Aesthetic Plast Surg, 2019,43(4):1095⁃1101. DOI: 10.1007/s00266⁃019⁃01373⁃x. |
| [1] | Committee on Skin Disease and Cosmetic Dermatology, China Association of Medical Equipment, Patient Education Expert Committee, Chinese Society of Clinical Oncology . Chinese expert consensus on multidisciplinary management of cancer treatment-related cutaneous adverse events (2026 edition) [J]. Chinese Journal of Dermatology, 2026, 59(4): 304-319. |
| [2] | Xue Shuyue, Li Tingting, Kang Xiaojing. Lipid metabolism in the occurrence, development, diagnosis and treatment of cutaneous malignancies [J]. Chinese Journal of Dermatology, 2026, 59(4): 379-382. |
| [3] | Group on Children, Chinese Society of Dermatology, Pediatric Dermatology Group, Chinese Association of Rehabilitation Dermatology, Pediatric Dermatology Group, China Dermatologist Association, External Therapy Group, Professional Committee for Children's Health and Drug Research, China Association of Traditional Chinese Medicine, Dermatology Group, China Pediatrician Association. Expert consensus on the diagnosis and treatment of pediatric alopecia areata in China (2026 edition) [J]. Chinese Journal of Dermatology, 2026, 59(4): 291-303. |
| [4] | Fan Huilin, Zhao Huimin, Peng Yiran, Wang Ben, Huang Yingxue, Zhao Zhixiang, Tang Yan, Jian Dan. Low-fluence fractional CO? laser in the treatment of refractory persistent erythema in patients with rosacea: a retrospective study [J]. Chinese Journal of Dermatology, 2026, 59(3): 218-223. |
| [5] | Zhu Yun, Wang Jiancai, Yang Ming, Gu Fei, Zhang Hongli, Gao Ying. Efficacy of 755-nm picosecond laser in the treatment of café-au-lait macules in children and analysis of its influencing factors [J]. Chinese Journal of Dermatology, 2026, 59(3): 224-229. |
| [6] | Xia Zhikuan, Ge Ge. Laser therapy for vitiligo: clinical applications and prospects [J]. Chinese Journal of Dermatology, 2026, 59(3): 213-217. |
| [7] | Luo Fei, Shi Yueyu, Xiao Peng, Di Linjin, Luo Shengqun, Zhang Xinjiang, Liu Zhiyong, Zhou Shuang. Comparison of efficacy of 2-year versus 1-year multidrug therapy for leprosy patients in Chongqing, 2007-2020 [J]. Chinese Journal of Dermatology, 2026, 59(3): 237-243. |
| [8] | Committee on Psoriasis, Chinese Society of Dermatology. Expert consensus on management of psoriasis with comorbidities (2026) [J]. Chinese Journal of Dermatology, 2026, 59(3): 193-207. |
| [9] | Expert Group on the Interpretation of the "Chinese expert consensus on the clinical application of photobiomodulation therapy in dermatology ()", Laser Medicine Group, Chinese Society of Dermatology. Interpretation of the Chinese expert consensus on the clinical application of photobiomodulation therapy in dermatology (2025) [J]. Chinese Journal of Dermatology, 2026, 59(3): 208-212. |
| [10] | Xu Guokang, Cai Mei. Sonidegib in the treatment of locally advanced basal cell carcinoma: a clinical analysis of eight cases [J]. Chinese Journal of Dermatology, 2026, 59(2): 166-169. |
| [11] | Chinese Society of Dermatology, China Dermatologist Association, Dermatology Branch of China International Exchange and Promotive Association for Medical and Health Care, Rare Skin Diseases Committee, China Alliance for Rare Diseases. Expert consensus on spesolimab in the treatment of inflammatory skin diseases (2026 edition) [J]. Chinese Journal of Dermatology, 2026, 59(2): 113-119. |
| [12] | Hair Disease Rehabilitation Group, Chinese Association of Rehabilitation Dermatology, Hair Medicine Branch, Beijing Association of Holistic Integrative Medicine, Hair Research Group, Chinese Society of Dermatology, National Clinical Research Center for Dermatologic and Immunologic Diseases. Chinese expert consensus on hair biopsy and pathology (2026 edition) [J]. Chinese Journal of Dermatology, 2026, 0(1): 20250580-e20250580. |
| [13] | Chinese Society of Dermatology, China Dermatologist Association. Expert consensus on the prevention, diagnosis, and treatment of nontuberculous mycobacterial skin infections associated with medical aesthetic procedures (2026 edition) [J]. Chinese Journal of Dermatology, 2026, 0(1): 20250537-e20250537. |
| [14] | Chinese Society of Dermatology, China Dermatologist Association, Dermatology Branch of China International Exchange and Promotive Association for Medical and Health Care, Dermatology Branch of China Alliance for Rare Diseases. Expert consensus on fecal microbiota transplantation in the treatment of psoriasis (2026 edition) [J]. Chinese Journal of Dermatology, 2026, 0(1): 20250564-e20250564. |
| [15] | Huang Hejin, Li Xinya, He Ziqing, Xi Wenwen, Tang Yujun, Zhang Jianfei, Xiao Xia, Jiang Bin, Yang Feng. Postoperative complications in 3 000 patients with axillary osmidrosis after minimally invasive rotary cutting surgery: a retrospective study [J]. Chinese Journal of Dermatology, 2026, 59(1): 62-64. |
|