核苷酸结合寡聚化结构域样受体蛋白3在雄激素性脱发发病中的作用及相关治疗进展

doi:10.35541/cjd.20250158

Abstract

Abstract: 【Abstract】 Androgenetic alopecia （AGA） is mainly characterized by hair follicle miniaturization and hair thinning. Its pathogenesis involves abnormal androgen metabolism, inflammation of the hair follicle microenvironment, and immune imbalance. Studies have shown that excessive activation of the nucleotide-binding oligomerization domain-like receptor protein 3 （NLRP3） inflammasome and imbalance of the gut microbiota-brain axis are closely associated with the development of AGA. This article reviews the mechanisms of the NLRP3 inflammasome and the gut microbiota-brain axis in the pathological progression of AGA, as well as therapeutic strategies targeting NLRP3-mediated immunomodulation for the treatment of AGA, with the aim of improving therapeutic outcomes.

Key words: Alopecia, NLR family, pyrin domain-containing 3 protein, Gastrointestinal microbiome, Gut microbiota-brain axis, Adipose-derived stem cell exosomes, Shengfa Yin

Huang Jinjin, Li Zhuqing, Lu Juanjuan, Li Shuhua, Cao Zhe, Xu Donghua, Wang Guoying, . Role of nucleotide-binding oligomerization domain-like receptor protein 3 in the pathogenesis of androgenetic alopecia and therapeutic advances[J]. Chinese Journal of Dermatology,2026,e20250158. doi:10.35541/cjd.20250158

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Role of nucleotide-binding oligomerization domain-like receptor protein 3 in the pathogenesis of androgenetic alopecia and therapeutic advances

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