Chinese Journal of Dermatology ›› 2025, e0240503.doi: 10.35541/cjd.20240503

• Reviews • Previous Articles    

Role of specialized pro-resolving mediators in psoriasis

Huang Shudai1, Zhou Xuyue2, Zhang Jiaan2, Chen Kun2   

  1. 1Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China; 2Department of Physical Therapy, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China
  • Received:2024-09-20 Revised:2024-12-26 Online:2025-01-24 Published:2025-09-09
  • Contact: Chen Kun E-mail:kunchen181@aliyun.com
  • Supported by:
    National Natural Science Foundation of China (82273552, 82203947, 82304049); Natural Science Foundation of Jiangsu Province (BK20220214); CAMS Innovation Fund for Medical Sciences (CIFMS 2021-I2M-1-001); Fundamental Research Funds for Central Universities in PUMC (3332023172)

Abstract: 【Abstract】 Psoriasis is a chronic inflammatory skin disorder characterized by aberrant activation of T lymphocytes and excessive proliferation of keratinocytes, with persistent inflammation being the central pathological feature. Specialized pro-resolving mediators (SPMs) exert anti-inflammatory effects through various mechanisms, actively facilitating the resolution of inflammation. The dual regulatory role in inflammation has garnered attention in the study of psoriasis pathogenesis. This review aims to consolidate recent advancements in SPMs, explore their specific roles in psoriasis pathogenesis, and evaluate their potential clinical application.

Key words: Psoriasis, Fatty acids, unsaturated, Lipoxins, Specialized pro-resolving mediators, Therapy, Inflammation mediators